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Pristine graphene induces cardiovascular defects in zebrafish (Danio rerio) embryogenesis.
Environ Pollut. 2018 Dec; 243(Pt A):246-254.EP

Abstract

The multiple effect of pristine graphene (pG) toxicity on cardiovascular developmental defects was assessed using zebrafish as a model. Recently, the nanotoxicity is emerging as a critical issue, and it is more significant in embryogenesis. Especially, graphene and its derivatives have attracted a lot of interest in biomedical applications. However, very little is known about the toxic effects of pG which has been widely used carbon nanomaterial according to concentration and its effects on biological and cardiovascular development. In the present study, we examined the development of zebrafish embryos by exposing to pG (5, 10, 15, 20 and 25 μg/L) under different developmental toxicity end-points such as cardiotoxicity, cardiovascular defect, retardation of cardiac looping, apoptosis and globin expression analysis. For this, the developmental cardiotoxicity of pG at different concentrations and the specific cardiovascular defects thereof were elucidated for the first time. As a result, the exposure to pG was found to be a potential risk factor to cardiovascular system of zebrafish embryos. However, a further study on the variations of physical, molecular properties and mechanisms of nanotoxicity which vary depending on production method and surface functionalization is required. In addition, the potential risks of pG flakes to aquatic organisms and human health should be considered or checked before releasing them to the environment.

Authors+Show Affiliations

Center for Biofluid and Biomimic Research, Pohang University of Science and Technology (POSTECH), Pohang, 37673, South Korea.Center for Biofluid and Biomimic Research, Pohang University of Science and Technology (POSTECH), Pohang, 37673, South Korea; Department of Mechanical Engineering, Pohang University of Science and Technology (POSTECH), Pohang, 37673, South Korea.Center for Biofluid and Biomimic Research, Pohang University of Science and Technology (POSTECH), Pohang, 37673, South Korea; Department of Mechanical Engineering, Pohang University of Science and Technology (POSTECH), Pohang, 37673, South Korea.Department of Zoology, University of Pune, Pune, India.Center for Biofluid and Biomimic Research, Pohang University of Science and Technology (POSTECH), Pohang, 37673, South Korea; Department of Mechanical Engineering, Pohang University of Science and Technology (POSTECH), Pohang, 37673, South Korea. Electronic address: sjlee@postech.ac.kr.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

30176498

Citation

Manjunatha, Bangeppagari, et al. "Pristine Graphene Induces Cardiovascular Defects in Zebrafish (Danio Rerio) Embryogenesis." Environmental Pollution (Barking, Essex : 1987), vol. 243, no. Pt A, 2018, pp. 246-254.
Manjunatha B, Park SH, Kim K, et al. Pristine graphene induces cardiovascular defects in zebrafish (Danio rerio) embryogenesis. Environ Pollut. 2018;243(Pt A):246-254.
Manjunatha, B., Park, S. H., Kim, K., Kundapur, R. R., & Lee, S. J. (2018). Pristine graphene induces cardiovascular defects in zebrafish (Danio rerio) embryogenesis. Environmental Pollution (Barking, Essex : 1987), 243(Pt A), 246-254. https://doi.org/10.1016/j.envpol.2018.08.058
Manjunatha B, et al. Pristine Graphene Induces Cardiovascular Defects in Zebrafish (Danio Rerio) Embryogenesis. Environ Pollut. 2018;243(Pt A):246-254. PubMed PMID: 30176498.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Pristine graphene induces cardiovascular defects in zebrafish (Danio rerio) embryogenesis. AU - Manjunatha,Bangeppagari, AU - Park,Sung Ho, AU - Kim,Kiwoong, AU - Kundapur,Rajesh R, AU - Lee,Sang Joon, Y1 - 2018/08/22/ PY - 2018/04/26/received PY - 2018/08/18/revised PY - 2018/08/19/accepted PY - 2018/9/4/pubmed PY - 2018/12/12/medline PY - 2018/9/4/entrez KW - Cardiotoxicity KW - Cardiovascular defects KW - Cellular apoptosis KW - Pristine graphene KW - Zebrafish embryo SP - 246 EP - 254 JF - Environmental pollution (Barking, Essex : 1987) JO - Environ. Pollut. VL - 243 IS - Pt A N2 - The multiple effect of pristine graphene (pG) toxicity on cardiovascular developmental defects was assessed using zebrafish as a model. Recently, the nanotoxicity is emerging as a critical issue, and it is more significant in embryogenesis. Especially, graphene and its derivatives have attracted a lot of interest in biomedical applications. However, very little is known about the toxic effects of pG which has been widely used carbon nanomaterial according to concentration and its effects on biological and cardiovascular development. In the present study, we examined the development of zebrafish embryos by exposing to pG (5, 10, 15, 20 and 25 μg/L) under different developmental toxicity end-points such as cardiotoxicity, cardiovascular defect, retardation of cardiac looping, apoptosis and globin expression analysis. For this, the developmental cardiotoxicity of pG at different concentrations and the specific cardiovascular defects thereof were elucidated for the first time. As a result, the exposure to pG was found to be a potential risk factor to cardiovascular system of zebrafish embryos. However, a further study on the variations of physical, molecular properties and mechanisms of nanotoxicity which vary depending on production method and surface functionalization is required. In addition, the potential risks of pG flakes to aquatic organisms and human health should be considered or checked before releasing them to the environment. SN - 1873-6424 UR - https://www.unboundmedicine.com/medline/citation/30176498/Pristine_graphene_induces_cardiovascular_defects_in_zebrafish__Danio_rerio__embryogenesis_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0269-7491(18)31871-2 DB - PRIME DP - Unbound Medicine ER -