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Temporal variation of oxidative potential of water soluble components of ambient PM2.5 measured by dithiothreitol (DTT) assay.
Sci Total Environ. 2019 Feb 01; 649:969-978.ST

Abstract

The exposure to ambient fine particulate matter (PM2.5) can induce oxidative stress, contributing to global burden of diseases. The evaluation of the oxidative potential (OP) of PM2.5 is thus critical for the health risk assessment. We collected ambient PM2.5 samples in Hangzhou city, China for four consecutive quarters in the year 2017 and investigated the oxidation property of PM2.5 components by the dithiothreitol (DTT) assay. The annual mean of ambient PM2.5 mass concentrations in 2017 was 63.05 μg m-3 (median: 57.34, range: 6.67-214.33 μg m-3) with the significant seasonal variations ranking as winter > spring > summer > autumn. Secondary inorganic aerosol (SIA) species including SO42-, NO3- and NH4+ totally account for >50% of PM2.5 mass. The annual mean volume-normalized DTT activity (DTTv) showed a relatively high value of 0.62 nmol/min/m3 (median: 0.62, range: 0.11-1.66 nmol/min/m3) and DTTv of four seasons was roughly at the same level, indicating a high annual exposure level of ambient PM2.5. SIA species were correlated well with the corresponding DTTv and showed significant diurnal variations with strong or moderate correlations at day and weak correlations at night, suggesting strong secondary formation in daytime with contribution to the particulate OP. The annual mean mass-normalized DTT activity (DTTm) had a relatively low value of 6.39 pmol/min/μg (median: 5.63, range: 1.99-22.70 pmol/min/μg), indicating low intrinsic oxidative toxicity. The DTTm of four seasons ranked as autumn > winter > spring > summer, indicating seasonal variations of the DTT-active components. The PM2.5 mass concentration is more related to exposure levels than intrinsic properties of components, while OP is determined by the components rather than PM2.5 mass concentration. Our results provide an insight into reactive oxygen species-induced health risk of PM2.5 exposure and decision for subsequent emission control.

Authors+Show Affiliations

College of Environmental and Resource Sciences, Zhejiang University, Hangzhou 310058, China.Yale-NUIST Center on Atmospheric Environment, Nanjing University of Information Science and Technology, Nanjing 210044, China.College of Environmental and Resource Sciences, Zhejiang University, Hangzhou 310058, China; Research Center for Air Pollution and Health, Zhejiang University, Hangzhou 310058, China.College of Environmental and Resource Sciences, Zhejiang University, Hangzhou 310058, China; Research Center for Air Pollution and Health, Zhejiang University, Hangzhou 310058, China.College of Marine Life Sciences, Ocean University of China, Qingdao 266003, China.College of Environmental and Resource Sciences, Zhejiang University, Hangzhou 310058, China.College of Environmental and Resource Sciences, Zhejiang University, Hangzhou 310058, China; Research Center for Air Pollution and Health, Zhejiang University, Hangzhou 310058, China.Yale-NUIST Center on Atmospheric Environment, Nanjing University of Information Science and Technology, Nanjing 210044, China.College of Environmental and Resource Sciences, Zhejiang University, Hangzhou 310058, China; The First Affiliated Hospital College of Medicine, Zhejiang University, Hangzhou 310003, China. Electronic address: shulin@zju.edu.cn.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

30179825

Citation

Wang, Jingpeng, et al. "Temporal Variation of Oxidative Potential of Water Soluble Components of Ambient PM2.5 Measured By Dithiothreitol (DTT) Assay." The Science of the Total Environment, vol. 649, 2019, pp. 969-978.
Wang J, Lin X, Lu L, et al. Temporal variation of oxidative potential of water soluble components of ambient PM2.5 measured by dithiothreitol (DTT) assay. Sci Total Environ. 2019;649:969-978.
Wang, J., Lin, X., Lu, L., Wu, Y., Zhang, H., Lv, Q., Liu, W., Zhang, Y., & Zhuang, S. (2019). Temporal variation of oxidative potential of water soluble components of ambient PM2.5 measured by dithiothreitol (DTT) assay. The Science of the Total Environment, 649, 969-978. https://doi.org/10.1016/j.scitotenv.2018.08.375
Wang J, et al. Temporal Variation of Oxidative Potential of Water Soluble Components of Ambient PM2.5 Measured By Dithiothreitol (DTT) Assay. Sci Total Environ. 2019 Feb 1;649:969-978. PubMed PMID: 30179825.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Temporal variation of oxidative potential of water soluble components of ambient PM2.5 measured by dithiothreitol (DTT) assay. AU - Wang,Jingpeng, AU - Lin,Xin, AU - Lu,Liping, AU - Wu,Yujie, AU - Zhang,Huanxin, AU - Lv,Qi, AU - Liu,Weiping, AU - Zhang,Yanlin, AU - Zhuang,Shulin, Y1 - 2018/08/28/ PY - 2018/06/29/received PY - 2018/08/25/revised PY - 2018/08/26/accepted PY - 2018/9/5/pubmed PY - 2018/12/12/medline PY - 2018/9/5/entrez KW - Fine particulate matter KW - Reactive oxygen species KW - Secondary inorganic aerosol KW - Temporal variation SP - 969 EP - 978 JF - The Science of the total environment JO - Sci. Total Environ. VL - 649 N2 - The exposure to ambient fine particulate matter (PM2.5) can induce oxidative stress, contributing to global burden of diseases. The evaluation of the oxidative potential (OP) of PM2.5 is thus critical for the health risk assessment. We collected ambient PM2.5 samples in Hangzhou city, China for four consecutive quarters in the year 2017 and investigated the oxidation property of PM2.5 components by the dithiothreitol (DTT) assay. The annual mean of ambient PM2.5 mass concentrations in 2017 was 63.05 μg m-3 (median: 57.34, range: 6.67-214.33 μg m-3) with the significant seasonal variations ranking as winter > spring > summer > autumn. Secondary inorganic aerosol (SIA) species including SO42-, NO3- and NH4+ totally account for >50% of PM2.5 mass. The annual mean volume-normalized DTT activity (DTTv) showed a relatively high value of 0.62 nmol/min/m3 (median: 0.62, range: 0.11-1.66 nmol/min/m3) and DTTv of four seasons was roughly at the same level, indicating a high annual exposure level of ambient PM2.5. SIA species were correlated well with the corresponding DTTv and showed significant diurnal variations with strong or moderate correlations at day and weak correlations at night, suggesting strong secondary formation in daytime with contribution to the particulate OP. The annual mean mass-normalized DTT activity (DTTm) had a relatively low value of 6.39 pmol/min/μg (median: 5.63, range: 1.99-22.70 pmol/min/μg), indicating low intrinsic oxidative toxicity. The DTTm of four seasons ranked as autumn > winter > spring > summer, indicating seasonal variations of the DTT-active components. The PM2.5 mass concentration is more related to exposure levels than intrinsic properties of components, while OP is determined by the components rather than PM2.5 mass concentration. Our results provide an insight into reactive oxygen species-induced health risk of PM2.5 exposure and decision for subsequent emission control. SN - 1879-1026 UR - https://www.unboundmedicine.com/medline/citation/30179825/Temporal_variation_of_oxidative_potential_of_water_soluble_components_of_ambient_PM2_5_measured_by_dithiothreitol__DTT__assay_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0048-9697(18)33346-1 DB - PRIME DP - Unbound Medicine ER -