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No associations between fruit and vegetable consumption and pancreatic cancer risk: a meta-analysis of prospective studies.
Oncotarget 2018; 9(63):32250-32261O

Abstract

The associations between fruit and vegetable consumption and pancreatic cancer risk are inconclusive. We conducted a meta-analysis of prospective studies to investigate the associations. The search was conducted systemically using the PubMed and EMBASE databases up to March 2017. Relative risks and 95% confidence intervals for the highest versus lowest consumption and dose-response analyses were assessed. Subtype and subgroup analyses were performed. Twelve studies were eligible. The summary relative risks of the highest versus lowest consumption were 0.95 (0.80-1.12) for total fruits and vegetables without heterogeneity (I2 = 0%, P = 0.44), 0.96 (0.82-1.12) for fruits without low heterogeneity (I2 = 37%, P = 0.12) and 0.94 (0.84-1.06) for vegetables with low heterogeneity (I2 = 9%, P= 0.36). Dose-response analyses also showed no significantly inverse associations for each 100 g/day increase; the summary relative risks were 1.00 (0.98-1.02) for total fruits and vegetables, 1.01 (0.97-1.05) for fruits and 1.00 (0.97-1.03) for vegetables. The results of subtype analyses were consistent with the fruit and vegetable analyses; the relative risks were 0.97 (0.80-1.17) for citrus fruit without low heterogeneity (I2 = 39%, P = 0.15) and 0.89 (0.76-1.05) for cruciferous vegetables without low heterogeneity (I2 = 14%, P = 0.32). In conclusion, this meta-analysis does not support significant associations between fruit and vegetable consumption and pancreatic cancer risk.

Authors+Show Affiliations

Department of Surgery, Navy General Hospital of PLA, Beijing, China. Xijing Hospital of Digestive Diseases, The Fourth Military Medical University, Xi'an, China.Xijing Hospital of Digestive Diseases, The Fourth Military Medical University, Xi'an, China.Xijing Hospital of Digestive Diseases, The Fourth Military Medical University, Xi'an, China.Shaanxi Maternal and Child Health Hospital, Shaanxi Province, Xi'an, China.Xijing Hospital of Digestive Diseases, The Fourth Military Medical University, Xi'an, China.The General Hospital of The People's Liberation Army, Department of General Surgery, Beijing, China.Xijing Hospital of Digestive Diseases, The Fourth Military Medical University, Xi'an, China.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

30181814

Citation

Zhao, Zhanwei, et al. "No Associations Between Fruit and Vegetable Consumption and Pancreatic Cancer Risk: a Meta-analysis of Prospective Studies." Oncotarget, vol. 9, no. 63, 2018, pp. 32250-32261.
Zhao Z, Yu P, Feng X, et al. No associations between fruit and vegetable consumption and pancreatic cancer risk: a meta-analysis of prospective studies. Oncotarget. 2018;9(63):32250-32261.
Zhao, Z., Yu, P., Feng, X., Yin, Z., Wang, S., Qiu, Z., & Zhao, Q. (2018). No associations between fruit and vegetable consumption and pancreatic cancer risk: a meta-analysis of prospective studies. Oncotarget, 9(63), pp. 32250-32261. doi:10.18632/oncotarget.23128.
Zhao Z, et al. No Associations Between Fruit and Vegetable Consumption and Pancreatic Cancer Risk: a Meta-analysis of Prospective Studies. Oncotarget. 2018 Aug 14;9(63):32250-32261. PubMed PMID: 30181814.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - No associations between fruit and vegetable consumption and pancreatic cancer risk: a meta-analysis of prospective studies. AU - Zhao,Zhanwei, AU - Yu,Pengfei, AU - Feng,Xiangying, AU - Yin,Zifang, AU - Wang,Shiqi, AU - Qiu,Zhaoyan, AU - Zhao,Qingchuan, Y1 - 2017/12/08/ PY - 2017/04/21/received PY - 2017/11/14/accepted PY - 2018/9/6/entrez PY - 2018/9/6/pubmed PY - 2018/9/6/medline KW - fruit KW - meta-analysis KW - pancreatic cancer KW - risk KW - vegetable SP - 32250 EP - 32261 JF - Oncotarget JO - Oncotarget VL - 9 IS - 63 N2 - The associations between fruit and vegetable consumption and pancreatic cancer risk are inconclusive. We conducted a meta-analysis of prospective studies to investigate the associations. The search was conducted systemically using the PubMed and EMBASE databases up to March 2017. Relative risks and 95% confidence intervals for the highest versus lowest consumption and dose-response analyses were assessed. Subtype and subgroup analyses were performed. Twelve studies were eligible. The summary relative risks of the highest versus lowest consumption were 0.95 (0.80-1.12) for total fruits and vegetables without heterogeneity (I2 = 0%, P = 0.44), 0.96 (0.82-1.12) for fruits without low heterogeneity (I2 = 37%, P = 0.12) and 0.94 (0.84-1.06) for vegetables with low heterogeneity (I2 = 9%, P= 0.36). Dose-response analyses also showed no significantly inverse associations for each 100 g/day increase; the summary relative risks were 1.00 (0.98-1.02) for total fruits and vegetables, 1.01 (0.97-1.05) for fruits and 1.00 (0.97-1.03) for vegetables. The results of subtype analyses were consistent with the fruit and vegetable analyses; the relative risks were 0.97 (0.80-1.17) for citrus fruit without low heterogeneity (I2 = 39%, P = 0.15) and 0.89 (0.76-1.05) for cruciferous vegetables without low heterogeneity (I2 = 14%, P = 0.32). In conclusion, this meta-analysis does not support significant associations between fruit and vegetable consumption and pancreatic cancer risk. SN - 1949-2553 UR - https://www.unboundmedicine.com/medline/citation/30181814/No_associations_between_fruit_and_vegetable_consumption_and_pancreatic_cancer_risk:_a_meta_analysis_of_prospective_studies_ L2 - http://www.impactjournals.com/oncotarget/misc/linkedout.php?pii=23128 DB - PRIME DP - Unbound Medicine ER -