Tags

Type your tag names separated by a space and hit enter

No associations between fruit and vegetable consumption and pancreatic cancer risk: a meta-analysis of prospective studies.

Abstract

The associations between fruit and vegetable consumption and pancreatic cancer risk are inconclusive. We conducted a meta-analysis of prospective studies to investigate the associations. The search was conducted systemically using the PubMed and EMBASE databases up to March 2017. Relative risks and 95% confidence intervals for the highest versus lowest consumption and dose-response analyses were assessed. Subtype and subgroup analyses were performed. Twelve studies were eligible. The summary relative risks of the highest versus lowest consumption were 0.95 (0.80-1.12) for total fruits and vegetables without heterogeneity (I2 = 0%, P = 0.44), 0.96 (0.82-1.12) for fruits without low heterogeneity (I2 = 37%, P = 0.12) and 0.94 (0.84-1.06) for vegetables with low heterogeneity (I2 = 9%, P= 0.36). Dose-response analyses also showed no significantly inverse associations for each 100 g/day increase; the summary relative risks were 1.00 (0.98-1.02) for total fruits and vegetables, 1.01 (0.97-1.05) for fruits and 1.00 (0.97-1.03) for vegetables. The results of subtype analyses were consistent with the fruit and vegetable analyses; the relative risks were 0.97 (0.80-1.17) for citrus fruit without low heterogeneity (I2 = 39%, P = 0.15) and 0.89 (0.76-1.05) for cruciferous vegetables without low heterogeneity (I2 = 14%, P = 0.32). In conclusion, this meta-analysis does not support significant associations between fruit and vegetable consumption and pancreatic cancer risk.

Links

  • PMC Free PDF
  • PMC Free Full Text
  • FREE Publisher Full Text
  • Authors+Show Affiliations

    ,

    Department of Surgery, Navy General Hospital of PLA, Beijing, China. Xijing Hospital of Digestive Diseases, The Fourth Military Medical University, Xi'an, China.

    ,

    Xijing Hospital of Digestive Diseases, The Fourth Military Medical University, Xi'an, China.

    ,

    Xijing Hospital of Digestive Diseases, The Fourth Military Medical University, Xi'an, China.

    ,

    Shaanxi Maternal and Child Health Hospital, Shaanxi Province, Xi'an, China.

    ,

    Xijing Hospital of Digestive Diseases, The Fourth Military Medical University, Xi'an, China.

    ,

    The General Hospital of The People's Liberation Army, Department of General Surgery, Beijing, China.

    Xijing Hospital of Digestive Diseases, The Fourth Military Medical University, Xi'an, China.

    Source

    Oncotarget 9:63 2018 Aug 14 pg 32250-32261

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    30181814

    Citation

    Zhao, Zhanwei, et al. "No Associations Between Fruit and Vegetable Consumption and Pancreatic Cancer Risk: a Meta-analysis of Prospective Studies." Oncotarget, vol. 9, no. 63, 2018, pp. 32250-32261.
    Zhao Z, Yu P, Feng X, et al. No associations between fruit and vegetable consumption and pancreatic cancer risk: a meta-analysis of prospective studies. Oncotarget. 2018;9(63):32250-32261.
    Zhao, Z., Yu, P., Feng, X., Yin, Z., Wang, S., Qiu, Z., & Zhao, Q. (2018). No associations between fruit and vegetable consumption and pancreatic cancer risk: a meta-analysis of prospective studies. Oncotarget, 9(63), pp. 32250-32261. doi:10.18632/oncotarget.23128.
    Zhao Z, et al. No Associations Between Fruit and Vegetable Consumption and Pancreatic Cancer Risk: a Meta-analysis of Prospective Studies. Oncotarget. 2018 Aug 14;9(63):32250-32261. PubMed PMID: 30181814.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - No associations between fruit and vegetable consumption and pancreatic cancer risk: a meta-analysis of prospective studies. AU - Zhao,Zhanwei, AU - Yu,Pengfei, AU - Feng,Xiangying, AU - Yin,Zifang, AU - Wang,Shiqi, AU - Qiu,Zhaoyan, AU - Zhao,Qingchuan, Y1 - 2017/12/08/ PY - 2017/04/21/received PY - 2017/11/14/accepted PY - 2018/9/6/entrez PY - 2018/9/6/pubmed PY - 2018/9/6/medline KW - fruit KW - meta-analysis KW - pancreatic cancer KW - risk KW - vegetable SP - 32250 EP - 32261 JF - Oncotarget JO - Oncotarget VL - 9 IS - 63 N2 - The associations between fruit and vegetable consumption and pancreatic cancer risk are inconclusive. We conducted a meta-analysis of prospective studies to investigate the associations. The search was conducted systemically using the PubMed and EMBASE databases up to March 2017. Relative risks and 95% confidence intervals for the highest versus lowest consumption and dose-response analyses were assessed. Subtype and subgroup analyses were performed. Twelve studies were eligible. The summary relative risks of the highest versus lowest consumption were 0.95 (0.80-1.12) for total fruits and vegetables without heterogeneity (I2 = 0%, P = 0.44), 0.96 (0.82-1.12) for fruits without low heterogeneity (I2 = 37%, P = 0.12) and 0.94 (0.84-1.06) for vegetables with low heterogeneity (I2 = 9%, P= 0.36). Dose-response analyses also showed no significantly inverse associations for each 100 g/day increase; the summary relative risks were 1.00 (0.98-1.02) for total fruits and vegetables, 1.01 (0.97-1.05) for fruits and 1.00 (0.97-1.03) for vegetables. The results of subtype analyses were consistent with the fruit and vegetable analyses; the relative risks were 0.97 (0.80-1.17) for citrus fruit without low heterogeneity (I2 = 39%, P = 0.15) and 0.89 (0.76-1.05) for cruciferous vegetables without low heterogeneity (I2 = 14%, P = 0.32). In conclusion, this meta-analysis does not support significant associations between fruit and vegetable consumption and pancreatic cancer risk. SN - 1949-2553 UR - https://www.unboundmedicine.com/medline/citation/30181814/No_associations_between_fruit_and_vegetable_consumption_and_pancreatic_cancer_risk:_a_meta_analysis_of_prospective_studies_ L2 - http://www.impactjournals.com/oncotarget/misc/linkedout.php?pii=23128 DB - PRIME DP - Unbound Medicine ER -