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Does Reinke's Edema Grade Determine Premalignant Potential?
Ann Otol Rhinol Laryngol. 2018 Nov; 127(11):812-816.AO

Abstract

OBJECTIVE

Reinke's edema (RE) is a benign disease of the vocal folds with a wide spectrum of clinical severity. We aim to evaluate the clinical impact of RE grade and determine if RE grade correlates with severity of dysplasia and tobacco exposure.

METHODS

Patients with isolated RE who underwent surgical excision between December 2010 and December 2014 were retrospectively reviewed. The RE grade was determined from archived laryngeal videostroboscopy exams. Pathologic severity of dysplasia, categorized by squamous intraepithelial neoplasia (SIN) classification, and tobacco history were extracted from medical records.

RESULTS

Of 95 lesions, 3 (3.16%) were RE grade 1, 33 (34.74%) were RE grade 2, 24 (25.26%) were RE grade 3, and 35 (36.84%) were RE grade 4. Fifty-nine lesions (62.11%) had no dysplasia (SIN0), 19 (20.00%) had mild dysplasia (SIN1), 15 (15.79%) had moderate dysplasia (SIN 2), and 2 (2.11%) had severe dysplasia (SIN3). The 2 patients with severe dysplasia had grade 4 lesions. No statistical correlation was identified between RE grade and the severity of dysplasia. Furthermore, no statistical correlation was seen between tobacco exposure and the severity of dysplasia or the RE grade.

CONCLUSIONS

Size of RE lesion does not reflect premalignancy. The majority of RE lesions, regardless of size, have little to no premalignant potential. Severe dysplasia/carcinoma in situ may be more likely seen in grade 4 lesions; however, the paucity of severe dysplasia published in RE data and in this cohort preclude any formal inference. Further study of grade 4 lesions is warranted.

Authors+Show Affiliations

1 Department of Head and Neck Surgery, University of California, Los Angeles, California, USA.2 Albert Einstein College of Medicine, Bronx, New York, USA.2 Albert Einstein College of Medicine, Bronx, New York, USA.3 Department of Otolaryngology, Montefiore Medical Center, Bronx, New York, USA.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

30187764

Citation

Tavaluc, Raluca, et al. "Does Reinke's Edema Grade Determine Premalignant Potential?" The Annals of Otology, Rhinology, and Laryngology, vol. 127, no. 11, 2018, pp. 812-816.
Tavaluc R, Herman H, Lin J, et al. Does Reinke's Edema Grade Determine Premalignant Potential? Ann Otol Rhinol Laryngol. 2018;127(11):812-816.
Tavaluc, R., Herman, H., Lin, J., & Tan, M. (2018). Does Reinke's Edema Grade Determine Premalignant Potential? The Annals of Otology, Rhinology, and Laryngology, 127(11), 812-816. https://doi.org/10.1177/0003489418796529
Tavaluc R, et al. Does Reinke's Edema Grade Determine Premalignant Potential. Ann Otol Rhinol Laryngol. 2018;127(11):812-816. PubMed PMID: 30187764.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Does Reinke's Edema Grade Determine Premalignant Potential? AU - Tavaluc,Raluca, AU - Herman,Howard, AU - Lin,Juan, AU - Tan,Melin, Y1 - 2018/09/06/ PY - 2018/9/7/pubmed PY - 2018/10/26/medline PY - 2018/9/7/entrez KW - Reinke’s edema KW - dysplasia KW - grading KW - larynx and tobacco exposure KW - vocal folds SP - 812 EP - 816 JF - The Annals of otology, rhinology, and laryngology JO - Ann. Otol. Rhinol. Laryngol. VL - 127 IS - 11 N2 - OBJECTIVE: Reinke's edema (RE) is a benign disease of the vocal folds with a wide spectrum of clinical severity. We aim to evaluate the clinical impact of RE grade and determine if RE grade correlates with severity of dysplasia and tobacco exposure. METHODS: Patients with isolated RE who underwent surgical excision between December 2010 and December 2014 were retrospectively reviewed. The RE grade was determined from archived laryngeal videostroboscopy exams. Pathologic severity of dysplasia, categorized by squamous intraepithelial neoplasia (SIN) classification, and tobacco history were extracted from medical records. RESULTS: Of 95 lesions, 3 (3.16%) were RE grade 1, 33 (34.74%) were RE grade 2, 24 (25.26%) were RE grade 3, and 35 (36.84%) were RE grade 4. Fifty-nine lesions (62.11%) had no dysplasia (SIN0), 19 (20.00%) had mild dysplasia (SIN1), 15 (15.79%) had moderate dysplasia (SIN 2), and 2 (2.11%) had severe dysplasia (SIN3). The 2 patients with severe dysplasia had grade 4 lesions. No statistical correlation was identified between RE grade and the severity of dysplasia. Furthermore, no statistical correlation was seen between tobacco exposure and the severity of dysplasia or the RE grade. CONCLUSIONS: Size of RE lesion does not reflect premalignancy. The majority of RE lesions, regardless of size, have little to no premalignant potential. Severe dysplasia/carcinoma in situ may be more likely seen in grade 4 lesions; however, the paucity of severe dysplasia published in RE data and in this cohort preclude any formal inference. Further study of grade 4 lesions is warranted. SN - 1943-572X UR - https://www.unboundmedicine.com/medline/citation/30187764/Does_Reinke's_Edema_Grade_Determine_Premalignant_Potential L2 - http://journals.sagepub.com/doi/full/10.1177/0003489418796529?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -