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[Lipid-lowering effect of propolis in mice with Triton-WR1339-induced hyperlipidemia and its mechanism for regulating lipid metabolism].
Nan Fang Yi Ke Da Xue Xue Bao. 2018 Jul 30; 38(8):1020-1024.NF

Abstract

OBJECTIVE

To evaluate the therapeutic effect of propolis against Triton-WR1339-induced hyperlipidemia in mice and explore the underlying mechanism.

METHODS

C57BL/6 mice were randomly divided into 7 groups (n=10), including the control group, hyperlipidemia model group, fenofibrate (30 mg/kg) treatment group, and 4 treatment groups treated with low- (30 mg/kg) or high-dose (60 mg/kg) propolis HB01 or HB02. In all but the control group, acute hyperlipidemia models were established by intramuscular injection of Triton WR-1339, and corresponding treatments were administered via gastric lavage for 7 days. After the treatments, blood samples were collected for testing the levels of total cholesterol (TC), triglycerides (TG), highdensity lipoprotein-cholesterol (HDL-C), low-density lipoprotein-cholesterol (LDL-C), malondialdehyde (MDA), superoxide dismutase (SOD), alanine aminotransferase (GPT), and aspartate aminotransferase (GOT); Western blotting was used to detect the expressions of the proteins involved in lipid metabolism in the liver tissues including ABCA1, ABCG8, LDLR, and SR-B1.

RESULTS

Compared with the normal control group, the mice with Triton-WR1339-induced hyperlipidemia showed significantly increased levels of TC, TG, LDL, MDA, GPT, and GOT and lowered HDL-C levels and SOD activity (P < 0.05). Treatments with fenofibrate and the 2 propolis at either low or high dose significantly reversed Triton-WR1339-induced changes in blood lipids (P < 0.05), and the effects of propolis were more potent. Triton-WR1339 injection also significantly decreased the expressions levels of ABCA1, ABCG8, LDLR, and SR-B1 in the liver (P < 0.05), and these changes were obviously reversed by treatments with fenofibrate and propolis (P < 0.05), especially by the latter.

CONCLUSIONS

The lipid-lowering effects of propolis are mediated by improving lipid metabolism and regulating the expressions of lipid transport proteins in the liver tissue.

Authors+Show Affiliations

Guangzhou University of Chinese Medicine, Guangzhou 510006, China. Dongguan Mathematical Engineering Academy of Chinese Medicine, Guangzhou University of Chinese Medicine, Dongguan 523808, China.Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou 510006, China.School of Pharmacy, Guangdong Pharmaceutical University, Guangzhou 510006, China.School of Pharmacy, Guangdong Pharmaceutical University, Guangzhou 510006, China.

Pub Type(s)

Journal Article

Language

chi

PubMed ID

30187881

Citation

Huang, Xiaoqi, et al. "[Lipid-lowering Effect of Propolis in Mice With Triton-WR1339-induced Hyperlipidemia and Its Mechanism for Regulating Lipid Metabolism]." Nan Fang Yi Ke Da Xue Xue Bao = Journal of Southern Medical University, vol. 38, no. 8, 2018, pp. 1020-1024.
Huang X, Wu X, Yan S, et al. [Lipid-lowering effect of propolis in mice with Triton-WR1339-induced hyperlipidemia and its mechanism for regulating lipid metabolism]. Nan Fang Yi Ke Da Xue Xue Bao. 2018;38(8):1020-1024.
Huang, X., Wu, X., Yan, S., & Lan, T. (2018). [Lipid-lowering effect of propolis in mice with Triton-WR1339-induced hyperlipidemia and its mechanism for regulating lipid metabolism]. Nan Fang Yi Ke Da Xue Xue Bao = Journal of Southern Medical University, 38(8), 1020-1024. https://doi.org/10.3969/j.issn.1673-4254.2018.08.20
Huang X, et al. [Lipid-lowering Effect of Propolis in Mice With Triton-WR1339-induced Hyperlipidemia and Its Mechanism for Regulating Lipid Metabolism]. Nan Fang Yi Ke Da Xue Xue Bao. 2018 Jul 30;38(8):1020-1024. PubMed PMID: 30187881.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Lipid-lowering effect of propolis in mice with Triton-WR1339-induced hyperlipidemia and its mechanism for regulating lipid metabolism]. AU - Huang,Xiaoqi, AU - Wu,Xiaoli, AU - Yan,Sishan, AU - Lan,Tian, PY - 2018/9/7/entrez PY - 2018/9/7/pubmed PY - 2019/2/15/medline KW - Triton-WR1339 KW - hypolipidemia KW - lipid metabolism KW - propolis SP - 1020 EP - 1024 JF - Nan fang yi ke da xue xue bao = Journal of Southern Medical University JO - Nan Fang Yi Ke Da Xue Xue Bao VL - 38 IS - 8 N2 - OBJECTIVE: To evaluate the therapeutic effect of propolis against Triton-WR1339-induced hyperlipidemia in mice and explore the underlying mechanism. METHODS: C57BL/6 mice were randomly divided into 7 groups (n=10), including the control group, hyperlipidemia model group, fenofibrate (30 mg/kg) treatment group, and 4 treatment groups treated with low- (30 mg/kg) or high-dose (60 mg/kg) propolis HB01 or HB02. In all but the control group, acute hyperlipidemia models were established by intramuscular injection of Triton WR-1339, and corresponding treatments were administered via gastric lavage for 7 days. After the treatments, blood samples were collected for testing the levels of total cholesterol (TC), triglycerides (TG), highdensity lipoprotein-cholesterol (HDL-C), low-density lipoprotein-cholesterol (LDL-C), malondialdehyde (MDA), superoxide dismutase (SOD), alanine aminotransferase (GPT), and aspartate aminotransferase (GOT); Western blotting was used to detect the expressions of the proteins involved in lipid metabolism in the liver tissues including ABCA1, ABCG8, LDLR, and SR-B1. RESULTS: Compared with the normal control group, the mice with Triton-WR1339-induced hyperlipidemia showed significantly increased levels of TC, TG, LDL, MDA, GPT, and GOT and lowered HDL-C levels and SOD activity (P < 0.05). Treatments with fenofibrate and the 2 propolis at either low or high dose significantly reversed Triton-WR1339-induced changes in blood lipids (P < 0.05), and the effects of propolis were more potent. Triton-WR1339 injection also significantly decreased the expressions levels of ABCA1, ABCG8, LDLR, and SR-B1 in the liver (P < 0.05), and these changes were obviously reversed by treatments with fenofibrate and propolis (P < 0.05), especially by the latter. CONCLUSIONS: The lipid-lowering effects of propolis are mediated by improving lipid metabolism and regulating the expressions of lipid transport proteins in the liver tissue. SN - 1673-4254 UR - https://www.unboundmedicine.com/medline/citation/30187881/[Lipid-lowering_effect_of_propolis_in_mice_with_Triton-WR1339-induced_hyperlipidemia_and_its_mechanism_for_regulating_lipid_metabolism] L2 - http://www.j-smu.com/Upload/html/2018081020.html DB - PRIME DP - Unbound Medicine ER -