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EEG source imaging of epileptic activity at seizure onset.
Epilepsy Res 2018; 146:160-171ER

Abstract

Surgical resection of the seizure onset zone (SOZ) requires that this region of the cortex is accurately localized. The onset of a seizure may be marked by transient discharges, but it also may be accompanied by oscillatory, sinusoidal electrographic activity, such as the EEG theta rhythm. However, because of the superposition of the seizure signal with other electrical signals, including noise artifacts and non-seizure brain activity, noninvasive Electrical Source Imaging (ESI) of the ictal EEG activity at seizure onset remains a challenging task for surgical planning. In the present study, we localize the SOZ from oscillatory features of the EEG at the ictal onset using 256-channel high density electroencephalography (HD-EEG), exact sensor positions, and individual electrical head models constructed from the patient's T1 magnetic resonance image (MRI). Epileptic activities at the seizure onset were characterized with joint time-frequency analysis and source estimated by standardized low resolution electromagnetic tomography (sLORETA) inverse method. The consistency of this localization was examined across multiple seizures for individual patients. For validation, results were compared to three clinical criteria: (1) epileptogenic lesions, (2) seizure onset observed in intracranial EEG, and (3) successful surgical outcomes. In this set of 84 seizures, the onsets of 56 seizures could be localized. For the lateralization measure, the results from HD-EEG with interictal spikes (8/10) and with ictal onset (10/10) were more accurate than international 10-20 EEG for interictal spikes (5/10) and ictal onset (5/10). ESI from HD-EEG with ictal onset (9/10) had greater concordance to the clinical criteria than HD-EEG with interictal spikes (6/10). Noninvasive ESI of oscillatory features at ictal onset using 256-channel HD-EEG and high-resolution individual head models can make a useful contribution to the clinical localization of the SOZ in presurgical planning.

Authors+Show Affiliations

Philips Neuro, Eugene, OR, USA; NeuroInformatics Center, University of Oregon, Eugene, OR, USA. Electronic address: benson.kuo@philips.com.NeuroInformatics Center, University of Oregon, Eugene, OR, USA; Department of Psychology, University of Oregon, Eugene, OR, USA.Department of Psychology, University of Oregon, Eugene, OR, USA.Department of Neurology/Regional Epilepsy Center, Harborview Medical Center, University of Washington, Seattle, WA, USA.Department of Neurology/Regional Epilepsy Center, Harborview Medical Center, University of Washington, Seattle, WA, USA.Department of Neurological Surgery, University of Washington, Seattle, WA, USA.Department of Neurology/Regional Epilepsy Center, Harborview Medical Center, University of Washington, Seattle, WA, USA.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

30189370

Citation

Kuo, Ching-Chang, et al. "EEG Source Imaging of Epileptic Activity at Seizure Onset." Epilepsy Research, vol. 146, 2018, pp. 160-171.
Kuo CC, Tucker DM, Luu P, et al. EEG source imaging of epileptic activity at seizure onset. Epilepsy Res. 2018;146:160-171.
Kuo, C. C., Tucker, D. M., Luu, P., Jenson, K., Tsai, J. J., Ojemann, J. G., & Holmes, M. D. (2018). EEG source imaging of epileptic activity at seizure onset. Epilepsy Research, 146, pp. 160-171. doi:10.1016/j.eplepsyres.2018.07.006.
Kuo CC, et al. EEG Source Imaging of Epileptic Activity at Seizure Onset. Epilepsy Res. 2018;146:160-171. PubMed PMID: 30189370.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - EEG source imaging of epileptic activity at seizure onset. AU - Kuo,Ching-Chang, AU - Tucker,Don M, AU - Luu,Phan, AU - Jenson,Kevin, AU - Tsai,Jeffrey J, AU - Ojemann,Jeffrey G, AU - Holmes,Mark D, Y1 - 2018/07/27/ PY - 2018/01/15/received PY - 2018/07/06/revised PY - 2018/07/16/accepted PY - 2018/9/7/pubmed PY - 2019/5/1/medline PY - 2018/9/7/entrez KW - Epilepsy KW - HD-EEG KW - Oscillation KW - Seizure KW - Source localization KW - Time-frequency SP - 160 EP - 171 JF - Epilepsy research JO - Epilepsy Res. VL - 146 N2 - Surgical resection of the seizure onset zone (SOZ) requires that this region of the cortex is accurately localized. The onset of a seizure may be marked by transient discharges, but it also may be accompanied by oscillatory, sinusoidal electrographic activity, such as the EEG theta rhythm. However, because of the superposition of the seizure signal with other electrical signals, including noise artifacts and non-seizure brain activity, noninvasive Electrical Source Imaging (ESI) of the ictal EEG activity at seizure onset remains a challenging task for surgical planning. In the present study, we localize the SOZ from oscillatory features of the EEG at the ictal onset using 256-channel high density electroencephalography (HD-EEG), exact sensor positions, and individual electrical head models constructed from the patient's T1 magnetic resonance image (MRI). Epileptic activities at the seizure onset were characterized with joint time-frequency analysis and source estimated by standardized low resolution electromagnetic tomography (sLORETA) inverse method. The consistency of this localization was examined across multiple seizures for individual patients. For validation, results were compared to three clinical criteria: (1) epileptogenic lesions, (2) seizure onset observed in intracranial EEG, and (3) successful surgical outcomes. In this set of 84 seizures, the onsets of 56 seizures could be localized. For the lateralization measure, the results from HD-EEG with interictal spikes (8/10) and with ictal onset (10/10) were more accurate than international 10-20 EEG for interictal spikes (5/10) and ictal onset (5/10). ESI from HD-EEG with ictal onset (9/10) had greater concordance to the clinical criteria than HD-EEG with interictal spikes (6/10). Noninvasive ESI of oscillatory features at ictal onset using 256-channel HD-EEG and high-resolution individual head models can make a useful contribution to the clinical localization of the SOZ in presurgical planning. SN - 1872-6844 UR - https://www.unboundmedicine.com/medline/citation/30189370/EEG_source_imaging_of_epileptic_activity_at_seizure_onset_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0920-1211(18)30017-2 DB - PRIME DP - Unbound Medicine ER -