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Do nitric oxide, carbon monoxide and hydrogen sulfide really qualify as 'gasotransmitters' in bacteria?
Biochem Soc Trans. 2018 10 19; 46(5):1107-1118.BS

Abstract

A gasotransmitter is defined as a small, generally reactive, gaseous molecule that, in solution, is generated endogenously in an organism and exerts important signalling roles. It is noteworthy that these molecules are also toxic and antimicrobial. We ask: is this definition of a gasotransmitter appropriate in the cases of nitric oxide, carbon monoxide and hydrogen sulfide (H2S) in microbes? Recent advances show that, not only do bacteria synthesise each of these gases, but the molecules also have important signalling or messenger roles in addition to their toxic effects. However, strict application of the criteria proposed for a gasotransmitter leads us to conclude that the term 'small molecule signalling agent', as proposed by Fukuto and others, is preferable terminology.

Authors+Show Affiliations

Vanderbilt University Medical Center, Vanderbilt Eye Institute, 11420 Medical Research Building IV, 215B Garland Avenue, Nashville, TN 37232-0654, U.S.A.Department of Molecular Biology and Biotechnology, The University of Sheffield, Firth Court, Sheffield S10 2TN, U.K.Department of Molecular Biology and Biotechnology, The University of Sheffield, Firth Court, Sheffield S10 2TN, U.K. r.poole@sheffield.ac.uk.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

30190328

Citation

Wareham, Lauren K., et al. "Do Nitric Oxide, Carbon Monoxide and Hydrogen Sulfide Really Qualify as 'gasotransmitters' in Bacteria?" Biochemical Society Transactions, vol. 46, no. 5, 2018, pp. 1107-1118.
Wareham LK, Southam HM, Poole RK. Do nitric oxide, carbon monoxide and hydrogen sulfide really qualify as 'gasotransmitters' in bacteria? Biochem Soc Trans. 2018;46(5):1107-1118.
Wareham, L. K., Southam, H. M., & Poole, R. K. (2018). Do nitric oxide, carbon monoxide and hydrogen sulfide really qualify as 'gasotransmitters' in bacteria? Biochemical Society Transactions, 46(5), 1107-1118. https://doi.org/10.1042/BST20170311
Wareham LK, Southam HM, Poole RK. Do Nitric Oxide, Carbon Monoxide and Hydrogen Sulfide Really Qualify as 'gasotransmitters' in Bacteria. Biochem Soc Trans. 2018 10 19;46(5):1107-1118. PubMed PMID: 30190328.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Do nitric oxide, carbon monoxide and hydrogen sulfide really qualify as 'gasotransmitters' in bacteria? AU - Wareham,Lauren K, AU - Southam,Hannah M, AU - Poole,Robert K, Y1 - 2018/09/06/ PY - 2018/06/07/received PY - 2018/07/27/revised PY - 2018/07/30/accepted PY - 2018/9/8/pubmed PY - 2019/3/8/medline PY - 2018/9/8/entrez KW - carbon monoxide KW - cellular signalling KW - gasotransmitters KW - hydrogen sulfide KW - nitric oxide SP - 1107 EP - 1118 JF - Biochemical Society transactions JO - Biochem Soc Trans VL - 46 IS - 5 N2 - A gasotransmitter is defined as a small, generally reactive, gaseous molecule that, in solution, is generated endogenously in an organism and exerts important signalling roles. It is noteworthy that these molecules are also toxic and antimicrobial. We ask: is this definition of a gasotransmitter appropriate in the cases of nitric oxide, carbon monoxide and hydrogen sulfide (H2S) in microbes? Recent advances show that, not only do bacteria synthesise each of these gases, but the molecules also have important signalling or messenger roles in addition to their toxic effects. However, strict application of the criteria proposed for a gasotransmitter leads us to conclude that the term 'small molecule signalling agent', as proposed by Fukuto and others, is preferable terminology. SN - 1470-8752 UR - https://www.unboundmedicine.com/medline/citation/30190328/Do_nitric_oxide_carbon_monoxide_and_hydrogen_sulfide_really_qualify_as_'gasotransmitters'_in_bacteria L2 - https://portlandpress.com/biochemsoctrans/article-lookup/doi/10.1042/BST20170311 DB - PRIME DP - Unbound Medicine ER -