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Oxidative stress-linked biomarkers in idiopathic pulmonary fibrosis: a systematic review and meta-analysis.
Biomark Med. 2018 10; 12(10):1175-1184.BM

Abstract

AIM

The aim of this meta-analysis was to investigate associations between idiopathic pulmonary fibrosis (IPF) and markers of oxidative stress (OS) measured in different biological samples.

METHODS

A systematic search of publications listed in PubMed, Web of Science, Scopus and Google Scholar from inception to December 2017 was conducted.

RESULTS

Significant differences between IPF patients and controls were observed for all biomarkers (thiobarbituric acid reactive substances, hydroperoxides and glutathione), barring systemic isoprostanes.

CONCLUSION

This meta-analysis showed a consistent increase in the concentrations of OS markers or a reduction in antioxidant markers, in patients with IPF, independent of the type of biological sample. Pending the results of further studies, OS biomarkers might be useful for the diagnosis and monitoring of IPF.

Authors+Show Affiliations

Department of Biomedical Sciences, University of Sassari, Viale San Pietro 43, 07100, Sassari, Italy.Department of Clinical, Surgical & Experimental Sciences, University of Sassari, Viale San Pietro 43, 07100, Sassari, Italy.Department of Clinical, Surgical & Experimental Sciences, University of Sassari, Viale San Pietro 43, 07100, Sassari, Italy.Department of Clinical, Surgical & Experimental Sciences, University of Sassari, Viale San Pietro 43, 07100, Sassari, Italy.Department of Clinical, Surgical & Experimental Sciences, University of Sassari, Viale San Pietro 43, 07100, Sassari, Italy.Department of Biomedical Sciences, University of Sassari, Viale San Pietro 43, 07100, Sassari, Italy.Department of Clinical, Surgical & Experimental Sciences, University of Sassari, Viale San Pietro 43, 07100, Sassari, Italy.Department of Clinical Pharmacology, College of Medicine & Public Health, Flinders University, Adelaide, Australia.Department of Biomedical Sciences, University of Sassari, Viale San Pietro 43, 07100, Sassari, Italy.

Pub Type(s)

Journal Article
Meta-Analysis
Systematic Review

Language

eng

PubMed ID

30191745

Citation

Paliogiannis, Panagiotis, et al. "Oxidative Stress-linked Biomarkers in Idiopathic Pulmonary Fibrosis: a Systematic Review and Meta-analysis." Biomarkers in Medicine, vol. 12, no. 10, 2018, pp. 1175-1184.
Paliogiannis P, Fois AG, Collu C, et al. Oxidative stress-linked biomarkers in idiopathic pulmonary fibrosis: a systematic review and meta-analysis. Biomark Med. 2018;12(10):1175-1184.
Paliogiannis, P., Fois, A. G., Collu, C., Bandinu, A., Zinellu, E., Carru, C., Pirina, P., Mangoni, A. A., & Zinellu, A. (2018). Oxidative stress-linked biomarkers in idiopathic pulmonary fibrosis: a systematic review and meta-analysis. Biomarkers in Medicine, 12(10), 1175-1184. https://doi.org/10.2217/bmm-2018-0108
Paliogiannis P, et al. Oxidative Stress-linked Biomarkers in Idiopathic Pulmonary Fibrosis: a Systematic Review and Meta-analysis. Biomark Med. 2018;12(10):1175-1184. PubMed PMID: 30191745.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Oxidative stress-linked biomarkers in idiopathic pulmonary fibrosis: a systematic review and meta-analysis. AU - Paliogiannis,Panagiotis, AU - Fois,Alessandro G, AU - Collu,Claudia, AU - Bandinu,Antonietta, AU - Zinellu,Elisabetta, AU - Carru,Ciriaco, AU - Pirina,Pietro, AU - Mangoni,Arduino A, AU - Zinellu,Angelo, Y1 - 2018/09/07/ PY - 2018/9/8/pubmed PY - 2019/9/4/medline PY - 2018/9/8/entrez KW - bronchoalveolar lavage fluid KW - epithelial lining fluid KW - expired breath condensate KW - glutathione KW - hydroperoxides KW - idiopathic pulmonary fibrosis KW - isoprostanes KW - lung KW - oxidative stress KW - protein carbonyls KW - systemic KW - thiobarbituric acid reactive substances SP - 1175 EP - 1184 JF - Biomarkers in medicine JO - Biomark Med VL - 12 IS - 10 N2 - AIM: The aim of this meta-analysis was to investigate associations between idiopathic pulmonary fibrosis (IPF) and markers of oxidative stress (OS) measured in different biological samples. METHODS: A systematic search of publications listed in PubMed, Web of Science, Scopus and Google Scholar from inception to December 2017 was conducted. RESULTS: Significant differences between IPF patients and controls were observed for all biomarkers (thiobarbituric acid reactive substances, hydroperoxides and glutathione), barring systemic isoprostanes. CONCLUSION: This meta-analysis showed a consistent increase in the concentrations of OS markers or a reduction in antioxidant markers, in patients with IPF, independent of the type of biological sample. Pending the results of further studies, OS biomarkers might be useful for the diagnosis and monitoring of IPF. SN - 1752-0371 UR - https://www.unboundmedicine.com/medline/citation/30191745/Oxidative_stress_linked_biomarkers_in_idiopathic_pulmonary_fibrosis:_a_systematic_review_and_meta_analysis_ L2 - http://www.futuremedicine.com/doi/full/10.2217/bmm-2018-0108?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -