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Peripheral neuropathy associated with mitochondrial myopathy.
Ann Neurol. 1986 Aug; 20(2):249-57.AN

Abstract

Twenty patients with mitochondrial myopathy were investigated for the presence of peripheral neuropathy. There were clinical features of a mild sensorimotor neuropathy in 5 patients (25%) and nerve conduction studies were abnormal in 10 patients (50%). Electrophysiological studies of the whole group showed significant impairment of motor and sensory conduction, compared with controls. Sural nerve biopsy and morphometric studies were performed on 4 patients with clinical neuropathy. There was a reduction in density of myelinated fibers and electron microscope features of axonal degeneration affecting myelinated and unmyelinated fibers. Abnormal mitochondria containing paracrystalline inclusions were seen in the Schwann cell cytoplasm of two nerves.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

3019229

Citation

Yiannikas, C, et al. "Peripheral Neuropathy Associated With Mitochondrial Myopathy." Annals of Neurology, vol. 20, no. 2, 1986, pp. 249-57.
Yiannikas C, McLeod JG, Pollard JD, et al. Peripheral neuropathy associated with mitochondrial myopathy. Ann Neurol. 1986;20(2):249-57.
Yiannikas, C., McLeod, J. G., Pollard, J. D., & Baverstock, J. (1986). Peripheral neuropathy associated with mitochondrial myopathy. Annals of Neurology, 20(2), 249-57.
Yiannikas C, et al. Peripheral Neuropathy Associated With Mitochondrial Myopathy. Ann Neurol. 1986;20(2):249-57. PubMed PMID: 3019229.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Peripheral neuropathy associated with mitochondrial myopathy. AU - Yiannikas,C, AU - McLeod,J G, AU - Pollard,J D, AU - Baverstock,J, PY - 1986/8/1/pubmed PY - 1986/8/1/medline PY - 1986/8/1/entrez SP - 249 EP - 57 JF - Annals of neurology JO - Ann. Neurol. VL - 20 IS - 2 N2 - Twenty patients with mitochondrial myopathy were investigated for the presence of peripheral neuropathy. There were clinical features of a mild sensorimotor neuropathy in 5 patients (25%) and nerve conduction studies were abnormal in 10 patients (50%). Electrophysiological studies of the whole group showed significant impairment of motor and sensory conduction, compared with controls. Sural nerve biopsy and morphometric studies were performed on 4 patients with clinical neuropathy. There was a reduction in density of myelinated fibers and electron microscope features of axonal degeneration affecting myelinated and unmyelinated fibers. Abnormal mitochondria containing paracrystalline inclusions were seen in the Schwann cell cytoplasm of two nerves. SN - 0364-5134 UR - https://www.unboundmedicine.com/medline/citation/3019229/Peripheral_neuropathy_associated_with_mitochondrial_myopathy_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0364-5134&date=1986&volume=20&issue=2&spage=249 DB - PRIME DP - Unbound Medicine ER -