Tags

Type your tag names separated by a space and hit enter

Prenatal exposure to bisphenol A and phthalates and behavioral problems in children at preschool age: the Hokkaido Study on Environment and Children's Health.
Environ Health Prev Med. 2018 Sep 07; 23(1):43.EH

Abstract

BACKGROUND

Studies reported adverse behavioral development including internalizing and externalizing problems in association with prenatal exposure to bisphenol A (BPA) and phthalates; however, findings were not sufficient due to using different assessment tools and child ages among studies. This study aimed to examine associations between maternal serum levels of BPA and phthalate metabolites and behavioral problems at preschool age.

METHODS

The Strengths and Difficulties Questionnaire (SDQ) was used to assess behavioral problems at 5 years of age. BPA and phthalate metabolite levels in the first trimester maternal serum was determined by LC-MS/MS for 458 children. Variables used for adjustment were parental ages, maternal cotinine levels, family income during pregnancy, child sex, birth order, and age at SDQ completed.

RESULTS

The median concentrations of BPA, MnBP, MiBP, MEHP, and MECPP, primary and secondary metabolites of phthalates, were 0.062, 26.0, 7.0, 1.40, and 0.20 ng/ml, respectively. MECPP level was associated with increase conduct problem risk (OR = 2.78, 95% CI 1.36-5.68) overall and the association remained after child sex stratification, and odds ratios were increased with wider confidence interval (OR = 2.85, 95% CI 1.07-7.57 for boys, OR = 4.04, 95% CI 1.31-12.5 for girls, respectively). BPA, ∑DBPm (MnBP + MiBP), and ∑DEHPm (MEHP+MECPP) levels were not associated with any of the child behavioral problems.

CONCLUSIONS

Our analyses found no significant association between BPA or summation of phthalate metabolite levels and any of the behavioral problems at 5 years of age but suggested possible association between MECPP levels and increased risk of conduct problems.

Authors+Show Affiliations

Center for Environmental and Health Sciences, Hokkaido University, Kita 12, Nishi 7, Kita-ku, Sapporo, 060-0812, Japan.Center for Environmental and Health Sciences, Hokkaido University, Kita 12, Nishi 7, Kita-ku, Sapporo, 060-0812, Japan.Center for Environmental and Health Sciences, Hokkaido University, Kita 12, Nishi 7, Kita-ku, Sapporo, 060-0812, Japan.Center for Environmental and Health Sciences, Hokkaido University, Kita 12, Nishi 7, Kita-ku, Sapporo, 060-0812, Japan.Center for Environmental and Health Sciences, Hokkaido University, Kita 12, Nishi 7, Kita-ku, Sapporo, 060-0812, Japan.Center for Environmental and Health Sciences, Hokkaido University, Kita 12, Nishi 7, Kita-ku, Sapporo, 060-0812, Japan.Institute of Environmental Ecology, IDEA Consultants, Inc., Shizuoka, Japan.Institute of Environmental Ecology, IDEA Consultants, Inc., Shizuoka, Japan.Institute of Environmental Ecology, IDEA Consultants, Inc., Shizuoka, Japan.Institute of Environmental Ecology, IDEA Consultants, Inc., Shizuoka, Japan.Center for Environmental and Health Sciences, Hokkaido University, Kita 12, Nishi 7, Kita-ku, Sapporo, 060-0812, Japan. rkishi@cehs.hokudai.ac.jp.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

30193567

Citation

Minatoya, Machiko, et al. "Prenatal Exposure to Bisphenol a and Phthalates and Behavioral Problems in Children at Preschool Age: the Hokkaido Study On Environment and Children's Health." Environmental Health and Preventive Medicine, vol. 23, no. 1, 2018, p. 43.
Minatoya M, Itoh S, Yamazaki K, et al. Prenatal exposure to bisphenol A and phthalates and behavioral problems in children at preschool age: the Hokkaido Study on Environment and Children's Health. Environ Health Prev Med. 2018;23(1):43.
Minatoya, M., Itoh, S., Yamazaki, K., Araki, A., Miyashita, C., Tamura, N., Yamamoto, J., Onoda, Y., Ogasawara, K., Matsumura, T., & Kishi, R. (2018). Prenatal exposure to bisphenol A and phthalates and behavioral problems in children at preschool age: the Hokkaido Study on Environment and Children's Health. Environmental Health and Preventive Medicine, 23(1), 43. https://doi.org/10.1186/s12199-018-0732-1
Minatoya M, et al. Prenatal Exposure to Bisphenol a and Phthalates and Behavioral Problems in Children at Preschool Age: the Hokkaido Study On Environment and Children's Health. Environ Health Prev Med. 2018 Sep 7;23(1):43. PubMed PMID: 30193567.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Prenatal exposure to bisphenol A and phthalates and behavioral problems in children at preschool age: the Hokkaido Study on Environment and Children's Health. AU - Minatoya,Machiko, AU - Itoh,Sachiko, AU - Yamazaki,Keiko, AU - Araki,Atsuko, AU - Miyashita,Chihiro, AU - Tamura,Naomi, AU - Yamamoto,Jun, AU - Onoda,Yu, AU - Ogasawara,Kazuki, AU - Matsumura,Toru, AU - Kishi,Reiko, Y1 - 2018/09/07/ PY - 2018/05/29/received PY - 2018/08/15/accepted PY - 2018/9/9/entrez PY - 2018/9/9/pubmed PY - 2019/1/8/medline KW - Behavioral problems KW - Birth cohort KW - Bisphenol A KW - Phthalates KW - Prenatal exposure KW - SDQ SP - 43 EP - 43 JF - Environmental health and preventive medicine JO - Environ Health Prev Med VL - 23 IS - 1 N2 - BACKGROUND: Studies reported adverse behavioral development including internalizing and externalizing problems in association with prenatal exposure to bisphenol A (BPA) and phthalates; however, findings were not sufficient due to using different assessment tools and child ages among studies. This study aimed to examine associations between maternal serum levels of BPA and phthalate metabolites and behavioral problems at preschool age. METHODS: The Strengths and Difficulties Questionnaire (SDQ) was used to assess behavioral problems at 5 years of age. BPA and phthalate metabolite levels in the first trimester maternal serum was determined by LC-MS/MS for 458 children. Variables used for adjustment were parental ages, maternal cotinine levels, family income during pregnancy, child sex, birth order, and age at SDQ completed. RESULTS: The median concentrations of BPA, MnBP, MiBP, MEHP, and MECPP, primary and secondary metabolites of phthalates, were 0.062, 26.0, 7.0, 1.40, and 0.20 ng/ml, respectively. MECPP level was associated with increase conduct problem risk (OR = 2.78, 95% CI 1.36-5.68) overall and the association remained after child sex stratification, and odds ratios were increased with wider confidence interval (OR = 2.85, 95% CI 1.07-7.57 for boys, OR = 4.04, 95% CI 1.31-12.5 for girls, respectively). BPA, ∑DBPm (MnBP + MiBP), and ∑DEHPm (MEHP+MECPP) levels were not associated with any of the child behavioral problems. CONCLUSIONS: Our analyses found no significant association between BPA or summation of phthalate metabolite levels and any of the behavioral problems at 5 years of age but suggested possible association between MECPP levels and increased risk of conduct problems. SN - 1347-4715 UR - https://www.unboundmedicine.com/medline/citation/30193567/Prenatal_exposure_to_bisphenol_A_and_phthalates_and_behavioral_problems_in_children_at_preschool_age:_the_Hokkaido_Study_on_Environment_and_Children's_Health_ L2 - https://environhealthprevmed.biomedcentral.com/articles/10.1186/s12199-018-0732-1 DB - PRIME DP - Unbound Medicine ER -