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Different lipid profiles, insulin sensitivity, and insulin resistance among Han, Uygur, and Kazak men with normal glucose tolerance in Xinjiang, China.
Lipids Health Dis 2018; 17(1):209LH

Abstract

BACKGROUND

This study aimed to determine the differences in clinical parameters among Han, Uygur, and Kazak men with normal glucose tolerance.

METHODS

Participants' data from the China National Diabetes and Metabolic Disorders Study pertaining to Han, Uygur, and Kazak men from the Xinjiang province were used (n = 930). Pearson's correlation was used to examine the relationship between HOMA-IR, Matsuda Index, and clinical characteristics.

RESULTS

HOMA-IR of Han men was significantly higher than in Uygurs and Kazaks (P < 0.001). The Matsuda Index of Kazaks was significantly higher than that of Hans and Uygurs (P < 0.001). While Kazaks had the highest BMI, WC, SBP, and DBP; they also had the highest HDL-C and lowest TG (P < 0.001). TG of Uygurs was significantly higher than that of Hans and Kazaks (P < 0.001). In Hans and Kazaks, the TG/HDL-C ratio increased with HOMA-IR quartiles; there was no association in Uygurs. In Hans and Kazaks, the TG/HDL-C ratio decreased with Matsuda index quartiles; there was no association in Uygurs. Multivariate linear regression showed that HOMA-IR was independently associated with ethnicity, BMI and TG/HDL-C ratio (P < 0.01), while Matsuda index was independently associated with ethnicity, BMI, LDL-C levels (P < 0.001) and TG/HDL-C ratio (P < 0.001).

CONCLUSIONS

In conclusion, Han, Uygur, and Kazak men had different lipid profiles, BMI, and WC. Han men had the highest insulin resistance while Kazak men had the highest insulin sensitivity.

Authors+Show Affiliations

Endocrinology Department of Xinjiang Uygur Autonomous Region People's Hospital, Urumqi, Xinjiang, 830001, China. wang_yan1996@163.com.School of Medicine, Shihezi University, Shihezi, Xinjiang, 832000, China.Endocrinology Department of Xinjiang Uygur Autonomous Region People's Hospital, Urumqi, Xinjiang, 830001, China.Endocrinology Department of Xinjiang Uygur Autonomous Region People's Hospital, Urumqi, Xinjiang, 830001, China.Endocrinology Department of Xinjiang Uygur Autonomous Region People's Hospital, Urumqi, Xinjiang, 830001, China.Xinjiang Medicine University, Urumqi, Xinjiang, 830001, China.Endocrinology Department of Xinjiang Uygur Autonomous Region People's Hospital, Urumqi, Xinjiang, 830001, China.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

30193578

Citation

Wang, Yan, et al. "Different Lipid Profiles, Insulin Sensitivity, and Insulin Resistance Among Han, Uygur, and Kazak Men With Normal Glucose Tolerance in Xinjiang, China." Lipids in Health and Disease, vol. 17, no. 1, 2018, p. 209.
Wang Y, Zhang J, Ma Y, et al. Different lipid profiles, insulin sensitivity, and insulin resistance among Han, Uygur, and Kazak men with normal glucose tolerance in Xinjiang, China. Lipids Health Dis. 2018;17(1):209.
Wang, Y., Zhang, J., Ma, Y., Song, X., Li, S., Zhan, X., & Wu, L. (2018). Different lipid profiles, insulin sensitivity, and insulin resistance among Han, Uygur, and Kazak men with normal glucose tolerance in Xinjiang, China. Lipids in Health and Disease, 17(1), p. 209. doi:10.1186/s12944-018-0863-9.
Wang Y, et al. Different Lipid Profiles, Insulin Sensitivity, and Insulin Resistance Among Han, Uygur, and Kazak Men With Normal Glucose Tolerance in Xinjiang, China. Lipids Health Dis. 2018 Sep 7;17(1):209. PubMed PMID: 30193578.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Different lipid profiles, insulin sensitivity, and insulin resistance among Han, Uygur, and Kazak men with normal glucose tolerance in Xinjiang, China. AU - Wang,Yan, AU - Zhang,Jun, AU - Ma,Yanrong, AU - Song,Xiangxin, AU - Li,Suli, AU - Zhan,Xianqin, AU - Wu,Lan, Y1 - 2018/09/07/ PY - 2018/07/03/received PY - 2018/08/31/accepted PY - 2018/9/9/entrez PY - 2018/9/9/pubmed PY - 2018/12/15/medline KW - Epidemiology KW - Ethnic differences KW - Glucose metabolism KW - Han KW - Insulin resistance KW - Insulin sensitivity KW - Kazak KW - Lipid metabolism KW - Uygur SP - 209 EP - 209 JF - Lipids in health and disease JO - Lipids Health Dis VL - 17 IS - 1 N2 - BACKGROUND: This study aimed to determine the differences in clinical parameters among Han, Uygur, and Kazak men with normal glucose tolerance. METHODS: Participants' data from the China National Diabetes and Metabolic Disorders Study pertaining to Han, Uygur, and Kazak men from the Xinjiang province were used (n = 930). Pearson's correlation was used to examine the relationship between HOMA-IR, Matsuda Index, and clinical characteristics. RESULTS: HOMA-IR of Han men was significantly higher than in Uygurs and Kazaks (P < 0.001). The Matsuda Index of Kazaks was significantly higher than that of Hans and Uygurs (P < 0.001). While Kazaks had the highest BMI, WC, SBP, and DBP; they also had the highest HDL-C and lowest TG (P < 0.001). TG of Uygurs was significantly higher than that of Hans and Kazaks (P < 0.001). In Hans and Kazaks, the TG/HDL-C ratio increased with HOMA-IR quartiles; there was no association in Uygurs. In Hans and Kazaks, the TG/HDL-C ratio decreased with Matsuda index quartiles; there was no association in Uygurs. Multivariate linear regression showed that HOMA-IR was independently associated with ethnicity, BMI and TG/HDL-C ratio (P < 0.01), while Matsuda index was independently associated with ethnicity, BMI, LDL-C levels (P < 0.001) and TG/HDL-C ratio (P < 0.001). CONCLUSIONS: In conclusion, Han, Uygur, and Kazak men had different lipid profiles, BMI, and WC. Han men had the highest insulin resistance while Kazak men had the highest insulin sensitivity. SN - 1476-511X UR - https://www.unboundmedicine.com/medline/citation/30193578/Different_lipid_profiles,_insulin_sensitivity,_and_insulin_resistance_among_Han,_Uygur,_and_Kazak_men_with_normal_glucose_tolerance_in_Xinjiang,_China L2 - https://lipidworld.biomedcentral.com/articles/10.1186/s12944-018-0863-9 DB - PRIME DP - Unbound Medicine ER -