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Diagnostic value of fluorine-18 deoxyglucose positron emission tomography/computed tomography in deep sternal wound infection.
J Plast Reconstr Aesthet Surg 2018; 71(12):1768-1776JP

Abstract

OBJECTIVES

Deep sternal wound infection (DSWI) is a refractory complication after heart surgery, and debridement is the first-line treatment. The accurate identification of the extent of the infection is the key to successful debridement. The present study assessed the diagnostic accuracy of fluorine-18 deoxyglucose (18F-FDG) positron emission tomography/computed tomography (PET/CT) for identifying the infected area of DSWI.

METHODS

Between February 2015 and May 2017, 73 consecutive patients with suspected DSWI received 18F-FDG PET/CT examinations before their operation. The PET/CT and extracted CT images were analyzed by nuclear medicine physicians and radiologists to determine whether the sternum, mediastinum, vascular prosthesis, and each costal cartilage were infected. All the patients received debridement and chest wall reconstruction within 1 week following the PET scan. The final diagnosis was on the basis of surgical, microbiological, and histopathological findings.

RESULTS

Of the 73 patients, 64, 54, 28, and 6 patients were diagnosed with sternal osteomyelitis, mediastinitis, costal chondritis, and vascular graft infection (VGI), respectively. The sensitivities of PET/CT for diagnosing sternal osteomyelitis, mediastinitis, and costal chondritis were 98.4%, 77.8%, and 100.0%, respectively, and the corresponding specificities were 94.7%, 82.1%, and 100.0%, respectively. PET/CT correctly diagnosed all six cases of VGI. There were 65 infected costal cartilages in the patients with costal chondritis. The sensitivity, specificity, and accuracy of PET/CT for locating infected costal cartilages were 81.5%, 99.8%, and 98.6%, respectively.

CONCLUSIONS

PET/CT proved to be a useful tool for determining the depth of DSWI and for locating infected costal cartilage; therefore, this tool can help guide debridement.

Authors+Show Affiliations

Department of Plastic and Reconstructive Surgery, Zhong-shan Hospital, 180 Fenglin Road, Xuhui District, Shanghai, China.Department of Plastic and Reconstructive Surgery, Zhong-shan Hospital, 180 Fenglin Road, Xuhui District, Shanghai, China.Department of Plastic and Reconstructive Surgery, Zhong-shan Hospital, 180 Fenglin Road, Xuhui District, Shanghai, China.Department of Nuclear Medicine, Zhong-shan Hospital, 180 Fenglin Road, Xuhui District, Shanghai, China.Department of Radiology, Zhong-shan Hospital, 180 Fenglin Road, Xuhui District, Shanghai, China.Department of Plastic and Reconstructive Surgery, Zhong-shan Hospital, 180 Fenglin Road, Xuhui District, Shanghai, China. Electronic address: Qi.fazhi@zs-hospital.sh.cn.

Pub Type(s)

Evaluation Studies
Journal Article

Language

eng

PubMed ID

30196022

Citation

Zhang, Rufan, et al. "Diagnostic Value of Fluorine-18 Deoxyglucose Positron Emission Tomography/computed Tomography in Deep Sternal Wound Infection." Journal of Plastic, Reconstructive & Aesthetic Surgery : JPRAS, vol. 71, no. 12, 2018, pp. 1768-1776.
Zhang R, Feng Z, Zhang Y, et al. Diagnostic value of fluorine-18 deoxyglucose positron emission tomography/computed tomography in deep sternal wound infection. J Plast Reconstr Aesthet Surg. 2018;71(12):1768-1776.
Zhang, R., Feng, Z., Zhang, Y., Tan, H., Wang, J., & Qi, F. (2018). Diagnostic value of fluorine-18 deoxyglucose positron emission tomography/computed tomography in deep sternal wound infection. Journal of Plastic, Reconstructive & Aesthetic Surgery : JPRAS, 71(12), pp. 1768-1776. doi:10.1016/j.bjps.2018.07.017.
Zhang R, et al. Diagnostic Value of Fluorine-18 Deoxyglucose Positron Emission Tomography/computed Tomography in Deep Sternal Wound Infection. J Plast Reconstr Aesthet Surg. 2018;71(12):1768-1776. PubMed PMID: 30196022.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Diagnostic value of fluorine-18 deoxyglucose positron emission tomography/computed tomography in deep sternal wound infection. AU - Zhang,Rufan, AU - Feng,Zihao, AU - Zhang,Yong, AU - Tan,Hui, AU - Wang,Jian, AU - Qi,Fazhi, Y1 - 2018/08/02/ PY - 2017/10/14/received PY - 2018/06/03/revised PY - 2018/07/27/accepted PY - 2018/9/10/pubmed PY - 2019/5/21/medline PY - 2018/9/10/entrez KW - (18)F-FDG PET/CT KW - Costal chondritis KW - Deep sternal wound infection KW - Mediastinitis KW - Sensitivity and specificity SP - 1768 EP - 1776 JF - Journal of plastic, reconstructive & aesthetic surgery : JPRAS JO - J Plast Reconstr Aesthet Surg VL - 71 IS - 12 N2 - OBJECTIVES: Deep sternal wound infection (DSWI) is a refractory complication after heart surgery, and debridement is the first-line treatment. The accurate identification of the extent of the infection is the key to successful debridement. The present study assessed the diagnostic accuracy of fluorine-18 deoxyglucose (18F-FDG) positron emission tomography/computed tomography (PET/CT) for identifying the infected area of DSWI. METHODS: Between February 2015 and May 2017, 73 consecutive patients with suspected DSWI received 18F-FDG PET/CT examinations before their operation. The PET/CT and extracted CT images were analyzed by nuclear medicine physicians and radiologists to determine whether the sternum, mediastinum, vascular prosthesis, and each costal cartilage were infected. All the patients received debridement and chest wall reconstruction within 1 week following the PET scan. The final diagnosis was on the basis of surgical, microbiological, and histopathological findings. RESULTS: Of the 73 patients, 64, 54, 28, and 6 patients were diagnosed with sternal osteomyelitis, mediastinitis, costal chondritis, and vascular graft infection (VGI), respectively. The sensitivities of PET/CT for diagnosing sternal osteomyelitis, mediastinitis, and costal chondritis were 98.4%, 77.8%, and 100.0%, respectively, and the corresponding specificities were 94.7%, 82.1%, and 100.0%, respectively. PET/CT correctly diagnosed all six cases of VGI. There were 65 infected costal cartilages in the patients with costal chondritis. The sensitivity, specificity, and accuracy of PET/CT for locating infected costal cartilages were 81.5%, 99.8%, and 98.6%, respectively. CONCLUSIONS: PET/CT proved to be a useful tool for determining the depth of DSWI and for locating infected costal cartilage; therefore, this tool can help guide debridement. SN - 1878-0539 UR - https://www.unboundmedicine.com/medline/citation/30196022/Diagnostic_value_of_fluorine_18_deoxyglucose_positron_emission_tomography/computed_tomography_in_deep_sternal_wound_infection_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1748-6815(18)30252-3 DB - PRIME DP - Unbound Medicine ER -