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Serum Lipid Profile and Its Association with Diabetes and Prediabetes in a Rural Bangladeshi Population.
Int J Environ Res Public Health. 2018 09 06; 15(9)IJ

Abstract

Dyslipidemia is commonly associated with diabetes (T2DM). This has been demonstrated for the Caucasian population, but few data are available for Asian Indians. The paper aims to investigate serum lipids (separately or in combination) and their association with glucose intolerance status (T2DM and prediabetes) in a rural Bangladeshi population. A sample of 2293 adults (≥20 years) were included in a community based cross-sectional survey in 2009. Anthropometric measures, blood pressure, blood glucose (fasting and 2-h oral glucose tolerance test) and fasting serum lipids (total cholesterol, T-Chol; triglycerides, Tg; low density lipoprotein cholesterol, LDL-C and high density lipoprotein cholesterol, HDL-C) were registered. Analysis of covariance (ANCOVA) and regression analysis were performed. High Tg levels were seen in 26% to 64% of the participants, depending on glucose tolerance status. Low HDL-C levels were seen in all groups (>90%). Significant linear trends were observed for high T-Chol, high Tg and low HDL-C with increasing glucose intolerance (p for trend <0.001). T2DM was significantly associated with high T-Chol (Odds ratio (OR): 2.43, p < 0.001), high Tg (OR: 3.91, p < 0.001) and low HDL-C (OR: 2.17, p = 0.044). Prediabetes showed a significant association with high Tg (OR: 1.96, p < 0.001) and low HDL-C (OR: 2.93, p = 0.011). Participants with combined high Tg and low HDL-C levels had a 12.75-fold higher OR for T2DM and 4.89 OR for prediabetes. In Asian Indian populations an assessment of serum lipids is warranted not only for T2DM patients, but also for those with prediabetes.

Authors+Show Affiliations

Department of Community Medicine and Global Health, University of Oslo, 0318 Oslo, Norway. doctorbiplob@yahoo.com. Centre for Global Health Research, Diabetic Association of Bangladesh, Dhaka 1000, Bangladesh. doctorbiplob@yahoo.com.Centre for Global Health Research, Diabetic Association of Bangladesh, Dhaka 1000, Bangladesh. tasnimasiddiquee08@yahoo.com.Department of Pathology, Ibrahim Medical College, Diabetic Association of Bangladesh, Dhaka 1000, Bangladesh. majumderanindita.rpmc@gmail.com.Bangladesh Institute of Research & Rehabilitation of Diabetes, Endocrine and Metabolic Disorders (BIRDEM), Dhaka 1000, Bangladesh. fariaafsana@yahoo.com.Bangladesh Institute of Research & Rehabilitation of Diabetes, Endocrine and Metabolic Disorders (BIRDEM), Dhaka 1000, Bangladesh. t.ahmed1963@gmail.com.Department of Community Medicine and Global Health, University of Oslo, 0318 Oslo, Norway. ibramdala@gmail.com.Department of Community Medicine and Global Health, University of Oslo, 0318 Oslo, Norway. naylacristinam@yahoo.com.br.Centre for Global Health Research, Diabetic Association of Bangladesh, Dhaka 1000, Bangladesh. president@dab-bd.org.Centre for Global Health Research, Diabetic Association of Bangladesh, Dhaka 1000, Bangladesh. hussain.akhtar@nord.no. Faculty of Health Science, NORD University, 8049 Bodo, Norway. hussain.akhtar@nord.no.Department of Community Medicine and Global Health, University of Oslo, 0318 Oslo, Norway. gerd.holmboe-ottesen@medisin.uio.no.Department of Community Medicine and Global Health, University of Oslo, 0318 Oslo, Norway. t.k.omsland@medisin.uio.no.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

30200612

Citation

Bhowmik, Bishwajit, et al. "Serum Lipid Profile and Its Association With Diabetes and Prediabetes in a Rural Bangladeshi Population." International Journal of Environmental Research and Public Health, vol. 15, no. 9, 2018.
Bhowmik B, Siddiquee T, Mujumder A, et al. Serum Lipid Profile and Its Association with Diabetes and Prediabetes in a Rural Bangladeshi Population. Int J Environ Res Public Health. 2018;15(9).
Bhowmik, B., Siddiquee, T., Mujumder, A., Afsana, F., Ahmed, T., Mdala, I. A., do V Moreira, N. C., Khan, A. K. A., Hussain, A., Holmboe-Ottesen, G., & Omsland, T. K. (2018). Serum Lipid Profile and Its Association with Diabetes and Prediabetes in a Rural Bangladeshi Population. International Journal of Environmental Research and Public Health, 15(9). https://doi.org/10.3390/ijerph15091944
Bhowmik B, et al. Serum Lipid Profile and Its Association With Diabetes and Prediabetes in a Rural Bangladeshi Population. Int J Environ Res Public Health. 2018 09 6;15(9) PubMed PMID: 30200612.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Serum Lipid Profile and Its Association with Diabetes and Prediabetes in a Rural Bangladeshi Population. AU - Bhowmik,Bishwajit, AU - Siddiquee,Tasnima, AU - Mujumder,Anindita, AU - Afsana,Faria, AU - Ahmed,Tareen, AU - Mdala,Ibrahimu A, AU - do V Moreira,Nayla Cristina, AU - Khan,Abul Kalam Azad, AU - Hussain,Akhtar, AU - Holmboe-Ottesen,Gerd, AU - Omsland,Tone Kristin, Y1 - 2018/09/06/ PY - 2018/06/30/received PY - 2018/08/29/revised PY - 2018/08/30/accepted PY - 2018/9/12/entrez PY - 2018/9/12/pubmed PY - 2019/2/2/medline KW - Bangladesh KW - diabetes KW - lipid profile KW - prediabetes JF - International journal of environmental research and public health JO - Int J Environ Res Public Health VL - 15 IS - 9 N2 - Dyslipidemia is commonly associated with diabetes (T2DM). This has been demonstrated for the Caucasian population, but few data are available for Asian Indians. The paper aims to investigate serum lipids (separately or in combination) and their association with glucose intolerance status (T2DM and prediabetes) in a rural Bangladeshi population. A sample of 2293 adults (≥20 years) were included in a community based cross-sectional survey in 2009. Anthropometric measures, blood pressure, blood glucose (fasting and 2-h oral glucose tolerance test) and fasting serum lipids (total cholesterol, T-Chol; triglycerides, Tg; low density lipoprotein cholesterol, LDL-C and high density lipoprotein cholesterol, HDL-C) were registered. Analysis of covariance (ANCOVA) and regression analysis were performed. High Tg levels were seen in 26% to 64% of the participants, depending on glucose tolerance status. Low HDL-C levels were seen in all groups (>90%). Significant linear trends were observed for high T-Chol, high Tg and low HDL-C with increasing glucose intolerance (p for trend <0.001). T2DM was significantly associated with high T-Chol (Odds ratio (OR): 2.43, p < 0.001), high Tg (OR: 3.91, p < 0.001) and low HDL-C (OR: 2.17, p = 0.044). Prediabetes showed a significant association with high Tg (OR: 1.96, p < 0.001) and low HDL-C (OR: 2.93, p = 0.011). Participants with combined high Tg and low HDL-C levels had a 12.75-fold higher OR for T2DM and 4.89 OR for prediabetes. In Asian Indian populations an assessment of serum lipids is warranted not only for T2DM patients, but also for those with prediabetes. SN - 1660-4601 UR - https://www.unboundmedicine.com/medline/citation/30200612/Serum_Lipid_Profile_and_Its_Association_with_Diabetes_and_Prediabetes_in_a_Rural_Bangladeshi_Population_ L2 - https://www.mdpi.com/resolver?pii=ijerph15091944 DB - PRIME DP - Unbound Medicine ER -