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Evidence of transplacental transmission of Encephalitozoon cuniculi genotype II in murine model.
Exp Parasitol. 2018 Oct; 193:51-57.EP

Abstract

Microsporidia are obligate intracellurar unicellular parasite of wide range of vertebrates. Although ingestion or inhalation of microsporidian spores is the main route of infection, assumed vertical transmission was described in some mammals. The present study was focused on proof of vertical transmission in mice under experimental conditions. Mice were infected with E. cuniculi genotype II intraperitoneally after mating, or perorally followed by mating in acute or chronic phase of infection. Fetuses were delivered by Caesarean section or mice were kept up to the parturition. Some of cubs were immediately after birth transferred to uninfected surrogate mothers. Group of cubs was immunosuppressed. All cubs were examined using polymerase chain reaction for the presence of Encephalitozoon after birth or in their age of 3 or 6 weeks, respectively. All fetuses delivered by Caesarean section, which were intraperitoneally or perorally infected were negative as well as all neonatal mice and youngsters tested in age of 6 weeks. Only immunosuppressed cubs and cubs of immunodeficient mice in age of 21 days were positive for Encephalitozoon cuniculi genotype II. Present results provided the evidence that transplacental transmission of Encephalitozoon cuniculi in mice occurs, but the mechanism of these transport is still unknown.

Authors+Show Affiliations

Institute of Parasitology, BC CAS, v.v.i., Czech Republic; Faculty of Agriculture, University of South Bohemia in České Budějovice, Czech Republic.Institute of Parasitology, BC CAS, v.v.i., Czech Republic. Electronic address: casio@paru.cas.cz.Institute of Parasitology, BC CAS, v.v.i., Czech Republic.Institute of Parasitology, BC CAS, v.v.i., Czech Republic.Institute of Parasitology, BC CAS, v.v.i., Czech Republic; Faculty of Agriculture, University of South Bohemia in České Budějovice, Czech Republic.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

30201451

Citation

Kotková, Michaela, et al. "Evidence of Transplacental Transmission of Encephalitozoon Cuniculi Genotype II in Murine Model." Experimental Parasitology, vol. 193, 2018, pp. 51-57.
Kotková M, Sak B, Hlásková L, et al. Evidence of transplacental transmission of Encephalitozoon cuniculi genotype II in murine model. Exp Parasitol. 2018;193:51-57.
Kotková, M., Sak, B., Hlásková, L., Květoňová, D., & Kváč, M. (2018). Evidence of transplacental transmission of Encephalitozoon cuniculi genotype II in murine model. Experimental Parasitology, 193, 51-57. https://doi.org/10.1016/j.exppara.2018.09.001
Kotková M, et al. Evidence of Transplacental Transmission of Encephalitozoon Cuniculi Genotype II in Murine Model. Exp Parasitol. 2018;193:51-57. PubMed PMID: 30201451.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Evidence of transplacental transmission of Encephalitozoon cuniculi genotype II in murine model. AU - Kotková,Michaela, AU - Sak,Bohumil, AU - Hlásková,Lenka, AU - Květoňová,Dana, AU - Kváč,Martin, Y1 - 2018/09/07/ PY - 2018/05/04/received PY - 2018/07/23/revised PY - 2018/09/04/accepted PY - 2018/9/12/pubmed PY - 2018/10/6/medline PY - 2018/9/12/entrez KW - BABL/c KW - Encephalitozoon cuniculi KW - Microsporidia KW - SCID KW - Transplacental transmission SP - 51 EP - 57 JF - Experimental parasitology JO - Exp. Parasitol. VL - 193 N2 - Microsporidia are obligate intracellurar unicellular parasite of wide range of vertebrates. Although ingestion or inhalation of microsporidian spores is the main route of infection, assumed vertical transmission was described in some mammals. The present study was focused on proof of vertical transmission in mice under experimental conditions. Mice were infected with E. cuniculi genotype II intraperitoneally after mating, or perorally followed by mating in acute or chronic phase of infection. Fetuses were delivered by Caesarean section or mice were kept up to the parturition. Some of cubs were immediately after birth transferred to uninfected surrogate mothers. Group of cubs was immunosuppressed. All cubs were examined using polymerase chain reaction for the presence of Encephalitozoon after birth or in their age of 3 or 6 weeks, respectively. All fetuses delivered by Caesarean section, which were intraperitoneally or perorally infected were negative as well as all neonatal mice and youngsters tested in age of 6 weeks. Only immunosuppressed cubs and cubs of immunodeficient mice in age of 21 days were positive for Encephalitozoon cuniculi genotype II. Present results provided the evidence that transplacental transmission of Encephalitozoon cuniculi in mice occurs, but the mechanism of these transport is still unknown. SN - 1090-2449 UR - https://www.unboundmedicine.com/medline/citation/30201451/Evidence_of_transplacental_transmission_of_Encephalitozoon_cuniculi_genotype_II_in_murine_model_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0014-4894(18)30230-3 DB - PRIME DP - Unbound Medicine ER -