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Acetaminophen (Paracetamol) Exposure During Pregnancy and Pubertal Development in Boys and Girls From a Nationwide Puberty Cohort.
Am J Epidemiol. 2019 01 01; 188(1):34-46.AJ

Abstract

This study explored the association between exposure to acetaminophen during pregnancy and pubertal development using data from 15,822 boys and girls in the longitudinal Puberty Cohort, nested within the Danish National Birth Cohort. Use of acetaminophen was reported 3 times during pregnancy and 6 months postpartum. In total, 54% of mothers indicated use at least once during pregnancy. Between 2012 and 2017, sons and daughters provided information on a wide range of pubertal milestones-including Tanner stages, axillary hair growth, and age at menarche or voice break and first ejaculation-every 6 months from 11 years of age until full sexual maturation. Data were analyzed using a regression model for interval-censored data, providing adjusted mean monthly differences in age at attaining the pubertal milestones according to intrauterine cumulative (weeks) and trimester-specific acetaminophen exposure. Our results suggested a tendency towards slightly earlier attainment of almost all studied markers of female pubertal development with increasing number of weeks of exposure (i.e., about 1.5-3 months earlier age at pubic hair, axillary hair, and acne development comparing unexposed with those prenatally exposed for more than 12 weeks). Male pubertal development had no strong association with acetaminophen exposure.

Authors+Show Affiliations

Section for Epidemiology, Department of Public Health, Aarhus University, Aarhus, Denmark. Department of Epidemiology, Fielding School of Public Health, University of California Los Angeles, Los Angeles, California.Section for Epidemiology, Department of Public Health, Aarhus University, Aarhus, Denmark. Department of Epidemiology, Fielding School of Public Health, University of California Los Angeles, Los Angeles, California.Section for Epidemiology, Department of Public Health, Aarhus University, Aarhus, Denmark.Department of Epidemiology, Fielding School of Public Health, University of California Los Angeles, Los Angeles, California. Department of Clinical Epidemiology, Aarhus University Hospital, Aarhus, Denmark.Section for Biostatistics, Department of Public Health, Aarhus University, Aarhus, Denmark.Department of Epidemiology, Fielding School of Public Health, University of California Los Angeles, Los Angeles, California.Section for Paediatric Urology, Department of Urology, Aarhus University Hospital, Aarhus, Denmark.Section for Epidemiology, Department of Public Health, Aarhus University, Aarhus, Denmark.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

30202914

Citation

Ernst, Andreas, et al. "Acetaminophen (Paracetamol) Exposure During Pregnancy and Pubertal Development in Boys and Girls From a Nationwide Puberty Cohort." American Journal of Epidemiology, vol. 188, no. 1, 2019, pp. 34-46.
Ernst A, Brix N, Lauridsen LLB, et al. Acetaminophen (Paracetamol) Exposure During Pregnancy and Pubertal Development in Boys and Girls From a Nationwide Puberty Cohort. Am J Epidemiol. 2019;188(1):34-46.
Ernst, A., Brix, N., Lauridsen, L. L. B., Olsen, J., Parner, E. T., Liew, Z., Olsen, L. H., & Ramlau-Hansen, C. H. (2019). Acetaminophen (Paracetamol) Exposure During Pregnancy and Pubertal Development in Boys and Girls From a Nationwide Puberty Cohort. American Journal of Epidemiology, 188(1), 34-46. https://doi.org/10.1093/aje/kwy193
Ernst A, et al. Acetaminophen (Paracetamol) Exposure During Pregnancy and Pubertal Development in Boys and Girls From a Nationwide Puberty Cohort. Am J Epidemiol. 2019 01 1;188(1):34-46. PubMed PMID: 30202914.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Acetaminophen (Paracetamol) Exposure During Pregnancy and Pubertal Development in Boys and Girls From a Nationwide Puberty Cohort. AU - Ernst,Andreas, AU - Brix,Nis, AU - Lauridsen,Lea L B, AU - Olsen,Jørn, AU - Parner,Erik T, AU - Liew,Zeyan, AU - Olsen,Lars H, AU - Ramlau-Hansen,Cecilia H, PY - 2018/02/05/received PY - 2018/08/21/accepted PY - 2018/9/12/pubmed PY - 2019/11/19/medline PY - 2018/9/12/entrez SP - 34 EP - 46 JF - American journal of epidemiology JO - Am J Epidemiol VL - 188 IS - 1 N2 - This study explored the association between exposure to acetaminophen during pregnancy and pubertal development using data from 15,822 boys and girls in the longitudinal Puberty Cohort, nested within the Danish National Birth Cohort. Use of acetaminophen was reported 3 times during pregnancy and 6 months postpartum. In total, 54% of mothers indicated use at least once during pregnancy. Between 2012 and 2017, sons and daughters provided information on a wide range of pubertal milestones-including Tanner stages, axillary hair growth, and age at menarche or voice break and first ejaculation-every 6 months from 11 years of age until full sexual maturation. Data were analyzed using a regression model for interval-censored data, providing adjusted mean monthly differences in age at attaining the pubertal milestones according to intrauterine cumulative (weeks) and trimester-specific acetaminophen exposure. Our results suggested a tendency towards slightly earlier attainment of almost all studied markers of female pubertal development with increasing number of weeks of exposure (i.e., about 1.5-3 months earlier age at pubic hair, axillary hair, and acne development comparing unexposed with those prenatally exposed for more than 12 weeks). Male pubertal development had no strong association with acetaminophen exposure. SN - 1476-6256 UR - https://www.unboundmedicine.com/medline/citation/30202914/Acetaminophen__Paracetamol__Exposure_During_Pregnancy_and_Pubertal_Development_in_Boys_and_Girls_From_a_Nationwide_Puberty_Cohort_ L2 - https://academic.oup.com/aje/article-lookup/doi/10.1093/aje/kwy193 DB - PRIME DP - Unbound Medicine ER -