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Association of Prenatal Urinary Concentrations of Phthalates and Bisphenol A and Pubertal Timing in Boys and Girls.
Environ Health Perspect. 2018 09; 126(9):97004.EH

Abstract

BACKGROUND

Animal studies suggest that phthalates and bisphenol A (BPA), endocrine-disrupting chemicals found in many consumer products, may impact the timing of puberty.

OBJECTIVES

We aimed to determine the association of prenatal exposure to high-molecular-weight phthalates and BPA with pubertal timing in boys and girls participating in the Center for the Health Assessment of Mothers and Children of Salinas (CHAMACOS) longitudinal cohort study.

METHODS

We quantified urinary concentrations of eight phthalate metabolites and BPA at two time points during pregnancy among participating mothers ([Formula: see text]) and conducted clinical Tanner staging of puberty on their children every 9 months between 9 and 13 y of age. We conducted accelerated failure time models and examined the role of child overweight/obese status in this association.

RESULTS

The sum of urinary metabolites of di(2-ethylhexyl) phthalate [Formula: see text], monobenzyl phthalate (MBzP), and BPA were associated with later onset of at least one of the three outcomes assessed in girls (thelarche, pubarche, or menarche) and with earlier onset of at least one of the two outcomes assessed in boys (gondarche and pubarche). We found that monocarboxynonyl phthalate, monocarboxyoctyl phthalate, mono(3-carboxypropyl) phthalate, and BPA were associated with later pubarche and menarche mostly among normal-weight girls but not overweight/obese girls. MBzP was associated with later thelarche in all girls, and [Formula: see text] was associated with later thelarche and menarche in all girls. BPA and all phthalate biomarkers were associated with earlier gonadarche and pubarche in all boys as well as in overweight/obese boys when stratified by weight. Among normal-weight boys, associations with BPA were also inverse, whereas associations with phthalate metabolites were close to the null or positive.

CONCLUSIONS

Several high-molecular-weight phthalates and BPA were associated with later puberty in girls and earlier puberty in boys included in the CHAMACOS cohort study. Childhood overweight/obesity may modify these associations. https://doi.org/10.1289/EHP3424.

Authors+Show Affiliations

1 Center for Environmental Research and Children's Health (CERCH) , School of Public Health, University of California, Berkeley , Berkeley, California, USA.1 Center for Environmental Research and Children's Health (CERCH) , School of Public Health, University of California, Berkeley , Berkeley, California, USA.1 Center for Environmental Research and Children's Health (CERCH) , School of Public Health, University of California, Berkeley , Berkeley, California, USA.1 Center for Environmental Research and Children's Health (CERCH) , School of Public Health, University of California, Berkeley , Berkeley, California, USA.2 Department of Pediatrics, University of California, San Francisco , San Francisco, California, USA.3 Department of Pediatrics, Kaiser Permanente , San Francisco, California, USA.1 Center for Environmental Research and Children's Health (CERCH) , School of Public Health, University of California, Berkeley , Berkeley, California, USA.4 Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention , Atlanta, Georgia, USA.4 Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention , Atlanta, Georgia, USA.1 Center for Environmental Research and Children's Health (CERCH) , School of Public Health, University of California, Berkeley , Berkeley, California, USA.

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, Non-P.H.S.

Language

eng

PubMed ID

30203993

Citation

Berger, Kimberly, et al. "Association of Prenatal Urinary Concentrations of Phthalates and Bisphenol a and Pubertal Timing in Boys and Girls." Environmental Health Perspectives, vol. 126, no. 9, 2018, p. 97004.
Berger K, Eskenazi B, Kogut K, et al. Association of Prenatal Urinary Concentrations of Phthalates and Bisphenol A and Pubertal Timing in Boys and Girls. Environ Health Perspect. 2018;126(9):97004.
Berger, K., Eskenazi, B., Kogut, K., Parra, K., Lustig, R. H., Greenspan, L. C., Holland, N., Calafat, A. M., Ye, X., & Harley, K. G. (2018). Association of Prenatal Urinary Concentrations of Phthalates and Bisphenol A and Pubertal Timing in Boys and Girls. Environmental Health Perspectives, 126(9), 97004. https://doi.org/10.1289/EHP3424
Berger K, et al. Association of Prenatal Urinary Concentrations of Phthalates and Bisphenol a and Pubertal Timing in Boys and Girls. Environ Health Perspect. 2018;126(9):97004. PubMed PMID: 30203993.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Association of Prenatal Urinary Concentrations of Phthalates and Bisphenol A and Pubertal Timing in Boys and Girls. AU - Berger,Kimberly, AU - Eskenazi,Brenda, AU - Kogut,Katherine, AU - Parra,Kimberly, AU - Lustig,Robert H, AU - Greenspan,Louise C, AU - Holland,Nina, AU - Calafat,Antonia M, AU - Ye,Xiaoyun, AU - Harley,Kim G, PY - 2018/9/12/entrez PY - 2018/9/12/pubmed PY - 2019/4/9/medline SP - 97004 EP - 97004 JF - Environmental health perspectives JO - Environ Health Perspect VL - 126 IS - 9 N2 - BACKGROUND: Animal studies suggest that phthalates and bisphenol A (BPA), endocrine-disrupting chemicals found in many consumer products, may impact the timing of puberty. OBJECTIVES: We aimed to determine the association of prenatal exposure to high-molecular-weight phthalates and BPA with pubertal timing in boys and girls participating in the Center for the Health Assessment of Mothers and Children of Salinas (CHAMACOS) longitudinal cohort study. METHODS: We quantified urinary concentrations of eight phthalate metabolites and BPA at two time points during pregnancy among participating mothers ([Formula: see text]) and conducted clinical Tanner staging of puberty on their children every 9 months between 9 and 13 y of age. We conducted accelerated failure time models and examined the role of child overweight/obese status in this association. RESULTS: The sum of urinary metabolites of di(2-ethylhexyl) phthalate [Formula: see text], monobenzyl phthalate (MBzP), and BPA were associated with later onset of at least one of the three outcomes assessed in girls (thelarche, pubarche, or menarche) and with earlier onset of at least one of the two outcomes assessed in boys (gondarche and pubarche). We found that monocarboxynonyl phthalate, monocarboxyoctyl phthalate, mono(3-carboxypropyl) phthalate, and BPA were associated with later pubarche and menarche mostly among normal-weight girls but not overweight/obese girls. MBzP was associated with later thelarche in all girls, and [Formula: see text] was associated with later thelarche and menarche in all girls. BPA and all phthalate biomarkers were associated with earlier gonadarche and pubarche in all boys as well as in overweight/obese boys when stratified by weight. Among normal-weight boys, associations with BPA were also inverse, whereas associations with phthalate metabolites were close to the null or positive. CONCLUSIONS: Several high-molecular-weight phthalates and BPA were associated with later puberty in girls and earlier puberty in boys included in the CHAMACOS cohort study. Childhood overweight/obesity may modify these associations. https://doi.org/10.1289/EHP3424. SN - 1552-9924 UR - https://www.unboundmedicine.com/medline/citation/30203993/Association_of_Prenatal_Urinary_Concentrations_of_Phthalates_and_Bisphenol_A_and_Pubertal_Timing_in_Boys_and_Girls_ L2 - https://ehp.niehs.nih.gov/doi/10.1289/EHP3424?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -