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Corn Oil Lowers Plasma Cholesterol Compared with Coconut Oil in Adults with Above-Desirable Levels of Cholesterol in a Randomized Crossover Trial.
J Nutr. 2018 10 01; 148(10):1556-1563.JN

Abstract

Background

Few trials have examined the effects of coconut oil consumption in comparison with polyunsaturated fatty acid-rich oils such as corn oil.

Objective

This trial assessed the effects of consuming foods made with corn oil compared with coconut oil on lipids, glucose homeostasis, and inflammation.

Methods

This was a preliminary randomized crossover study of men (n = 12) and women (n = 13) with a mean age of 45.2 y, mean body mass index (in kg/m2) of 27.7, fasting LDL cholesterol ≥115 mg/dL and <190 mg/dL, and triglycerides (TGs) ≤375 mg/dL. Subjects consumed muffins and rolls providing 4 tablespoons (∼54 g) per day of corn oil or coconut oil as part of their habitual diets for 4 wk, with a 3-wk washout between conditions. Fasting plasma lipids and high-sensitivity C-reactive protein (hs-CRP) and glucose metabolism were assessed via an intravenous glucose tolerance test at baseline and 15 and 29 d of treatment. Responses were compared between treatments by ANCOVA.

Results

Median baseline concentrations of LDL cholesterol, non-HDL cholesterol, total cholesterol (total-C), HDL cholesterol, total-C:HDL cholesterol, and TGs were 123, 144, 188, 46.0, 4.21, and 92.5 mg/dL, respectively. Changes from baseline for corn oil and coconut oil conditions, respectively, were: LDL cholesterol (primary outcome; -2.7% compared with +4.6%), non-HDL cholesterol (-3.0% compared with +5.8%), total-C (-0.5% compared with +7.1%), HDL cholesterol (+5.4% compared with +6.5%), total-C:HDL cholesterol (-4.3% compared with -3.3%), and TGs (-2.1% compared with +6.0%). Non-HDL cholesterol responses were significantly different between corn and coconut oil conditions (P = 0.034); differences between conditions in total-C and LDL cholesterol approached significance (both P = 0.06). Responses for hs-CRP and carbohydrate homeostasis parameters did not differ significantly between diet conditions.

Conclusions

When incorporated into the habitual diet, consumption of foods providing ∼54 g of corn oil/d produced a more favorable plasma lipid profile than did coconut oil in adults with elevated cholesterol. This trial was registered at clinicaltrials.gov as NCT03202654.

Authors+Show Affiliations

Midwest Biomedical Research: Center for Metabolic and Cardiovascular Health, Glen Ellyn, IL. Great Lakes Clinical Trials, Chicago, IL.Great Lakes Clinical Trials, Chicago, IL.Midwest Biomedical Research: Center for Metabolic and Cardiovascular Health, Glen Ellyn, IL.Midwest Biomedical Research: Center for Metabolic and Cardiovascular Health, Glen Ellyn, IL.MB Clinical Research, Boca Raton, FL.ACH Food Companies Inc., Oakbrook Terrace, IL.ACH Food Companies Inc., Oakbrook Terrace, IL.

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

30204921

Citation

Maki, Kevin C., et al. "Corn Oil Lowers Plasma Cholesterol Compared With Coconut Oil in Adults With Above-Desirable Levels of Cholesterol in a Randomized Crossover Trial." The Journal of Nutrition, vol. 148, no. 10, 2018, pp. 1556-1563.
Maki KC, Hasse W, Dicklin MR, et al. Corn Oil Lowers Plasma Cholesterol Compared with Coconut Oil in Adults with Above-Desirable Levels of Cholesterol in a Randomized Crossover Trial. J Nutr. 2018;148(10):1556-1563.
Maki, K. C., Hasse, W., Dicklin, M. R., Bell, M., Buggia, M. A., Cassens, M. E., & Eren, F. (2018). Corn Oil Lowers Plasma Cholesterol Compared with Coconut Oil in Adults with Above-Desirable Levels of Cholesterol in a Randomized Crossover Trial. The Journal of Nutrition, 148(10), 1556-1563. https://doi.org/10.1093/jn/nxy156
Maki KC, et al. Corn Oil Lowers Plasma Cholesterol Compared With Coconut Oil in Adults With Above-Desirable Levels of Cholesterol in a Randomized Crossover Trial. J Nutr. 2018 10 1;148(10):1556-1563. PubMed PMID: 30204921.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Corn Oil Lowers Plasma Cholesterol Compared with Coconut Oil in Adults with Above-Desirable Levels of Cholesterol in a Randomized Crossover Trial. AU - Maki,Kevin C, AU - Hasse,Wendy, AU - Dicklin,Mary R, AU - Bell,Marjorie, AU - Buggia,Mary A, AU - Cassens,Martha E, AU - Eren,Fulya, PY - 2018/04/26/received PY - 2018/06/27/accepted PY - 2018/9/12/pubmed PY - 2019/5/6/medline PY - 2018/9/12/entrez SP - 1556 EP - 1563 JF - The Journal of nutrition JO - J Nutr VL - 148 IS - 10 N2 - Background: Few trials have examined the effects of coconut oil consumption in comparison with polyunsaturated fatty acid-rich oils such as corn oil. Objective: This trial assessed the effects of consuming foods made with corn oil compared with coconut oil on lipids, glucose homeostasis, and inflammation. Methods: This was a preliminary randomized crossover study of men (n = 12) and women (n = 13) with a mean age of 45.2 y, mean body mass index (in kg/m2) of 27.7, fasting LDL cholesterol ≥115 mg/dL and <190 mg/dL, and triglycerides (TGs) ≤375 mg/dL. Subjects consumed muffins and rolls providing 4 tablespoons (∼54 g) per day of corn oil or coconut oil as part of their habitual diets for 4 wk, with a 3-wk washout between conditions. Fasting plasma lipids and high-sensitivity C-reactive protein (hs-CRP) and glucose metabolism were assessed via an intravenous glucose tolerance test at baseline and 15 and 29 d of treatment. Responses were compared between treatments by ANCOVA. Results: Median baseline concentrations of LDL cholesterol, non-HDL cholesterol, total cholesterol (total-C), HDL cholesterol, total-C:HDL cholesterol, and TGs were 123, 144, 188, 46.0, 4.21, and 92.5 mg/dL, respectively. Changes from baseline for corn oil and coconut oil conditions, respectively, were: LDL cholesterol (primary outcome; -2.7% compared with +4.6%), non-HDL cholesterol (-3.0% compared with +5.8%), total-C (-0.5% compared with +7.1%), HDL cholesterol (+5.4% compared with +6.5%), total-C:HDL cholesterol (-4.3% compared with -3.3%), and TGs (-2.1% compared with +6.0%). Non-HDL cholesterol responses were significantly different between corn and coconut oil conditions (P = 0.034); differences between conditions in total-C and LDL cholesterol approached significance (both P = 0.06). Responses for hs-CRP and carbohydrate homeostasis parameters did not differ significantly between diet conditions. Conclusions: When incorporated into the habitual diet, consumption of foods providing ∼54 g of corn oil/d produced a more favorable plasma lipid profile than did coconut oil in adults with elevated cholesterol. This trial was registered at clinicaltrials.gov as NCT03202654. SN - 1541-6100 UR - https://www.unboundmedicine.com/medline/citation/30204921/Corn_Oil_Lowers_Plasma_Cholesterol_Compared_with_Coconut_Oil_in_Adults_with_Above_Desirable_Levels_of_Cholesterol_in_a_Randomized_Crossover_Trial_ L2 - https://academic.oup.com/jn/article-lookup/doi/10.1093/jn/nxy156 DB - PRIME DP - Unbound Medicine ER -