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Adipose tissue palmitoleic acid is inversely associated with nonfatal acute myocardial infarction in Costa Rican adults.
Nutr Metab Cardiovasc Dis. 2018 10; 28(10):973-979.NM

Abstract

BACKGROUND AND AIMS

Animal models have shown that adipose-derived palmitoleic acid may act as a lipokine by conferring resistance to diet-induced obesity; however, human epidemiologic studies investigating this relationship thus far have not provided data in support of this hypothesis. Because metabolic syndrome and cardiovascular disease are intricately linked with the former being a major risk factor for the latter, we hypothesized that adipose-derived palmitoleic acid may be inversely associated with myocardial infarction. We examined whether adipose tissue palmitoleic acid was associated with nonfatal acute myocardial infarction in a representative population of Costa Rican adults.

METHODS AND RESULTS

Odds ratios of nonfatal acute myocardial infarction by quintiles of adipose tissue palmitoleic acid were calculated using conditional logistic regression in a case-control study of 1828 cases and 1828 controls matched by age, sex, and area of residence. We observed an inverse relationship between nonfatal acute myocardial infarction and adipose tissue palmitoleic acid (OR for highest quintile compared to lowest quintile of palmitoleic acid: 0.55; 95% CI: 0.41, 0.75; P for trend: <0.0001). We additionally observed a significant positive association between adipose tissue palmitoleic acid and high-density lipoprotein cholesterol.

CONCLUSION

These data demonstrate an inverse association between adipose tissue palmitoleic acid and nonfatal acute myocardial infarction; however, further research is required in order to better understand the opposing associations between palmitoleic acid and high-density lipoprotein cholesterol and systolic blood pressure.

Authors+Show Affiliations

Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI 48109, USA.Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI 48109, USA.Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA; Centro de Investigación e Innovación en Nutricion Traslacional y Salud, Universidad Hispanoamericana, San Jose, Costa Rica.Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI 48109, USA; Department of Nutritional Sciences, School of Public Health, University of Michigan, Ann Arbor, MI 48109, USA. Electronic address: abaylin@umich.edu.

Pub Type(s)

Journal Article
Observational Study
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

30207271

Citation

Luan, D, et al. "Adipose Tissue Palmitoleic Acid Is Inversely Associated With Nonfatal Acute Myocardial Infarction in Costa Rican Adults." Nutrition, Metabolism, and Cardiovascular Diseases : NMCD, vol. 28, no. 10, 2018, pp. 973-979.
Luan D, Wang D, Campos H, et al. Adipose tissue palmitoleic acid is inversely associated with nonfatal acute myocardial infarction in Costa Rican adults. Nutr Metab Cardiovasc Dis. 2018;28(10):973-979.
Luan, D., Wang, D., Campos, H., & Baylin, A. (2018). Adipose tissue palmitoleic acid is inversely associated with nonfatal acute myocardial infarction in Costa Rican adults. Nutrition, Metabolism, and Cardiovascular Diseases : NMCD, 28(10), 973-979. https://doi.org/10.1016/j.numecd.2018.05.004
Luan D, et al. Adipose Tissue Palmitoleic Acid Is Inversely Associated With Nonfatal Acute Myocardial Infarction in Costa Rican Adults. Nutr Metab Cardiovasc Dis. 2018;28(10):973-979. PubMed PMID: 30207271.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Adipose tissue palmitoleic acid is inversely associated with nonfatal acute myocardial infarction in Costa Rican adults. AU - Luan,D, AU - Wang,D, AU - Campos,H, AU - Baylin,A, Y1 - 2018/06/28/ PY - 2017/11/13/received PY - 2018/05/02/revised PY - 2018/05/03/accepted PY - 2018/9/13/entrez PY - 2018/9/13/pubmed PY - 2019/3/15/medline KW - Adipose tissue palmitoleic acid KW - Case–control study KW - Costa Rican adults KW - HDL cholesterol KW - Metabolic syndrome KW - Nonfatal acute myocardial infarction SP - 973 EP - 979 JF - Nutrition, metabolism, and cardiovascular diseases : NMCD JO - Nutr Metab Cardiovasc Dis VL - 28 IS - 10 N2 - BACKGROUND AND AIMS: Animal models have shown that adipose-derived palmitoleic acid may act as a lipokine by conferring resistance to diet-induced obesity; however, human epidemiologic studies investigating this relationship thus far have not provided data in support of this hypothesis. Because metabolic syndrome and cardiovascular disease are intricately linked with the former being a major risk factor for the latter, we hypothesized that adipose-derived palmitoleic acid may be inversely associated with myocardial infarction. We examined whether adipose tissue palmitoleic acid was associated with nonfatal acute myocardial infarction in a representative population of Costa Rican adults. METHODS AND RESULTS: Odds ratios of nonfatal acute myocardial infarction by quintiles of adipose tissue palmitoleic acid were calculated using conditional logistic regression in a case-control study of 1828 cases and 1828 controls matched by age, sex, and area of residence. We observed an inverse relationship between nonfatal acute myocardial infarction and adipose tissue palmitoleic acid (OR for highest quintile compared to lowest quintile of palmitoleic acid: 0.55; 95% CI: 0.41, 0.75; P for trend: <0.0001). We additionally observed a significant positive association between adipose tissue palmitoleic acid and high-density lipoprotein cholesterol. CONCLUSION: These data demonstrate an inverse association between adipose tissue palmitoleic acid and nonfatal acute myocardial infarction; however, further research is required in order to better understand the opposing associations between palmitoleic acid and high-density lipoprotein cholesterol and systolic blood pressure. SN - 1590-3729 UR - https://www.unboundmedicine.com/medline/citation/30207271/Adipose_tissue_palmitoleic_acid_is_inversely_associated_with_nonfatal_acute_myocardial_infarction_in_Costa_Rican_adults_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0939-4753(18)30157-1 DB - PRIME DP - Unbound Medicine ER -