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[Contrasting effect of piracetam and proline on the release of 3H-D-aspartic acid from the cerebral cortical synaptosomes of rats].
Biull Eksp Biol Med. 1986 Oct; 102(10):440-2.BE

Abstract

Piracetam (at concentrations of 10(-6) and 10(-5), but not 10(-4) and 5 X 10(-4) M) decreased K+-stimulated 3H-D-aspartate release. Proline enhanced K+-stimulated D-aspartate release, and its effect was antagonized by piracetam at a concentration that had no effect on K+-stimulated release. Quisqualic acid attenuated K+-stimulated D-aspartate release, with the effect antagonized by GDEE. GDEE also blocked the effect of piracetam, but not proline. The data are discussed in terms of the role of excitatory amino acid neurotransmission in the mechanisms of amnestic and antihypoxic piracetam action.

Authors

Prikhozhan AV
No affiliation info available
Kovalev GI
No affiliation info available

MeSH

AnimalsAspartic AcidCerebral CortexDose-Response Relationship, DrugDrug InteractionsMalePiracetamProlinePyrrolidinonesRatsRats, Inbred StrainsReceptors, Amino AcidReceptors, GlutamateReceptors, NeurotransmitterSynaptosomesTritium

Pub Type(s)

Comparative Study
English Abstract
Journal Article

Language

rus

PubMed ID

3021261

Citation

Prikhozhan, A V., and G I. Kovalev. "[Contrasting Effect of Piracetam and Proline On the Release of 3H-D-aspartic Acid From the Cerebral Cortical Synaptosomes of Rats]." Biulleten' Eksperimental'noi Biologii I Meditsiny, vol. 102, no. 10, 1986, pp. 440-2.
Prikhozhan AV, Kovalev GI. [Contrasting effect of piracetam and proline on the release of 3H-D-aspartic acid from the cerebral cortical synaptosomes of rats]. Biull Eksp Biol Med. 1986;102(10):440-2.
Prikhozhan, A. V., & Kovalev, G. I. (1986). [Contrasting effect of piracetam and proline on the release of 3H-D-aspartic acid from the cerebral cortical synaptosomes of rats]. Biulleten' Eksperimental'noi Biologii I Meditsiny, 102(10), 440-2.
Prikhozhan AV, Kovalev GI. [Contrasting Effect of Piracetam and Proline On the Release of 3H-D-aspartic Acid From the Cerebral Cortical Synaptosomes of Rats]. Biull Eksp Biol Med. 1986;102(10):440-2. PubMed PMID: 3021261.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Contrasting effect of piracetam and proline on the release of 3H-D-aspartic acid from the cerebral cortical synaptosomes of rats]. AU - Prikhozhan,A V, AU - Kovalev,G I, PY - 1986/10/1/pubmed PY - 1986/10/1/medline PY - 1986/10/1/entrez SP - 440 EP - 2 JF - Biulleten' eksperimental'noi biologii i meditsiny JO - Biull Eksp Biol Med VL - 102 IS - 10 N2 - Piracetam (at concentrations of 10(-6) and 10(-5), but not 10(-4) and 5 X 10(-4) M) decreased K+-stimulated 3H-D-aspartate release. Proline enhanced K+-stimulated D-aspartate release, and its effect was antagonized by piracetam at a concentration that had no effect on K+-stimulated release. Quisqualic acid attenuated K+-stimulated D-aspartate release, with the effect antagonized by GDEE. GDEE also blocked the effect of piracetam, but not proline. The data are discussed in terms of the role of excitatory amino acid neurotransmission in the mechanisms of amnestic and antihypoxic piracetam action. SN - 0365-9615 UR - https://www.unboundmedicine.com/medline/citation/3021261/[Contrasting_effect_of_piracetam_and_proline_on_the_release_of_3H_D_aspartic_acid_from_the_cerebral_cortical_synaptosomes_of_rats]_ DB - PRIME DP - Unbound Medicine ER -