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Retrospective analysis of children with myelin oligodendrocyte glycoprotein antibody-related disorders.
Mult Scler Relat Disord. 2018 Nov; 26:1-7.MS

Abstract

BACKGROUND

Knowledge has been expanding on myelin oligodendrocyte glycoprotein (MOG) antibody-associated central nervous system disorders. We delineate the clinical and paraclinical findings and outcome of our pediatric patients with MOG antibody seropositive disease.

METHODS

We retrospectively analyzed the clinical presentation, cerebrospinal fluid findings, magnetic resonance imaging (MRI) studies, course and outcome of children seropositive for anti-MOG IgG.

RESULTS

Total 20 children with neurological symptoms and serum anti-MOG IgG were identified from six centers in Turkey. Median age at onset was 9 years (mean 8.8 ± 5.0 years, range: 1.5-16.5 years). Final diagnoses were acute disseminated encephalomyelitis (ADEM) (n = 5), ADEM + optic neuritis (n = 4), neuromyelitis optica spectrum disorder (NMOSD) (n = 3), myelitis (n = 2), relapsing optic neuritis (n = 2), multiphasic DEM (n = 3), and unclassified relapsing demyelinating disease (n = 1). Seven/20 (35%) children experienced a single episode while 13/20 (65%) had a least one relapse during follow-up. On MRI, subcortical white matter, brainstem, and corpus callosum were preferentially involved regions. Full recovery was observed in 15/20 (75%) children.

CONCLUSION

MOG autoimmunity in children has a wide clinical spectrum, tendency to relapse, and a favourable outcome compared with other relapsing demyelinating diseases.

Authors+Show Affiliations

Department of Pediatric Neurology, Hacettepe University Ihsan Dogramaci Children's Hospital, Ankara, Turkey.Department of Pediatric Neurology, Konya Research and Training Hospital, Konya, Turkey. Electronic address: miracyildirim81@hotmail.com.Department of Radiology, Hacettepe University Hospitals, Ankara, Turkey.Department of Pediatric Neurology, Dokuz Eylul University Hospital, Izmir, Turkey.Department of Pediatric Neurology, Dokuz Eylul University Hospital, Izmir, Turkey.Department of Pediatric Neurology, Istanbul University Cerrahpasa School of Medicine Hospital, Istanbul, Turkey. Electronic address: kilichuseyin@me.com.Department of Pediatric Neurology, Istanbul University Cerrahpasa School of Medicine Hospital, Istanbul, Turkey. Electronic address: semasaltik@superonline.com.Department of Pediatric Neurology, Gazi University Hospital, Ankara, Turkey.Department of Pediatric Neurology, Gazi University Hospital, Ankara, Turkey. Electronic address: kivilcim@gazi.edu.tr.Department of Pediatric Neurology, Cukurova University Hospital, Adana, Turkey.Department of Pediatric Neurology, Adana Numune Research and Training Hospital, Adana, Turkey.Department of Pediatric Neurology, Sisli Hamidiye Etfal Research and Training Hospital, Istanbul, Turkey.Department of Pediatric Neurology, Ankara Research and Training Hospital, Ankara, Turkey.Department of Pediatric Neurology, Mersin University Hospital, Mersin, Turkey.Department of Pediatric Neurology, Dr. Sami Ulus Research and Training Hospital, Ankara, Turkey.Department of Pediatric Neurology, Hacettepe University Ihsan Dogramaci Children's Hospital, Ankara, Turkey. Electronic address: banlar@hacettepe.edu.tr.

Pub Type(s)

Journal Article
Multicenter Study

Language

eng

PubMed ID

30212767

Citation

Konuskan, Bahadır, et al. "Retrospective Analysis of Children With Myelin Oligodendrocyte Glycoprotein Antibody-related Disorders." Multiple Sclerosis and Related Disorders, vol. 26, 2018, pp. 1-7.
Konuskan B, Yildirim M, Gocmen R, et al. Retrospective analysis of children with myelin oligodendrocyte glycoprotein antibody-related disorders. Mult Scler Relat Disord. 2018;26:1-7.
Konuskan, B., Yildirim, M., Gocmen, R., Okur, T. D., Polat, I., Kilic, H., Saltik, S., Ozturk, Z., Gucuyener, K., Altunbasak, S., Celik, T., Kose, G., Yilmaz, A., Komur, M., Kayilioglu, H., & Anlar, B. (2018). Retrospective analysis of children with myelin oligodendrocyte glycoprotein antibody-related disorders. Multiple Sclerosis and Related Disorders, 26, 1-7. https://doi.org/10.1016/j.msard.2018.07.022
Konuskan B, et al. Retrospective Analysis of Children With Myelin Oligodendrocyte Glycoprotein Antibody-related Disorders. Mult Scler Relat Disord. 2018;26:1-7. PubMed PMID: 30212767.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Retrospective analysis of children with myelin oligodendrocyte glycoprotein antibody-related disorders. AU - Konuskan,Bahadır, AU - Yildirim,Mirac, AU - Gocmen,Rahsan, AU - Okur,Tuncay Derya, AU - Polat,Ipek, AU - Kilic,Huseyin, AU - Saltik,Sema, AU - Ozturk,Zeynep, AU - Gucuyener,Kivilcim, AU - Altunbasak,Sakir, AU - Celik,Tamer, AU - Kose,Gulsen, AU - Yilmaz,Arzu, AU - Komur,Mustafa, AU - Kayilioglu,Hulya, AU - Anlar,Banu, Y1 - 2018/09/10/ PY - 2018/02/10/received PY - 2018/04/26/revised PY - 2018/07/11/accepted PY - 2018/9/14/pubmed PY - 2019/3/1/medline PY - 2018/9/14/entrez KW - Antibody KW - Demyelinating diseases KW - MRI KW - Myelin oligodendrocyte glycoprotein KW - Neuroimmunology SP - 1 EP - 7 JF - Multiple sclerosis and related disorders JO - Mult Scler Relat Disord VL - 26 N2 - BACKGROUND: Knowledge has been expanding on myelin oligodendrocyte glycoprotein (MOG) antibody-associated central nervous system disorders. We delineate the clinical and paraclinical findings and outcome of our pediatric patients with MOG antibody seropositive disease. METHODS: We retrospectively analyzed the clinical presentation, cerebrospinal fluid findings, magnetic resonance imaging (MRI) studies, course and outcome of children seropositive for anti-MOG IgG. RESULTS: Total 20 children with neurological symptoms and serum anti-MOG IgG were identified from six centers in Turkey. Median age at onset was 9 years (mean 8.8 ± 5.0 years, range: 1.5-16.5 years). Final diagnoses were acute disseminated encephalomyelitis (ADEM) (n = 5), ADEM + optic neuritis (n = 4), neuromyelitis optica spectrum disorder (NMOSD) (n = 3), myelitis (n = 2), relapsing optic neuritis (n = 2), multiphasic DEM (n = 3), and unclassified relapsing demyelinating disease (n = 1). Seven/20 (35%) children experienced a single episode while 13/20 (65%) had a least one relapse during follow-up. On MRI, subcortical white matter, brainstem, and corpus callosum were preferentially involved regions. Full recovery was observed in 15/20 (75%) children. CONCLUSION: MOG autoimmunity in children has a wide clinical spectrum, tendency to relapse, and a favourable outcome compared with other relapsing demyelinating diseases. SN - 2211-0356 UR - https://www.unboundmedicine.com/medline/citation/30212767/Retrospective_analysis_of_children_with_myelin_oligodendrocyte_glycoprotein_antibody_related_disorders_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S2211-0348(18)30234-7 DB - PRIME DP - Unbound Medicine ER -