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Associations of the risk of lung cancer with serum 25-hydroxyvitamin D level and dietary vitamin D intake: A dose-response PRISMA meta-analysis.
Medicine (Baltimore) 2018; 97(37):e12282M

Abstract

The associations of the risk of lung cancer with the vitamin D intake and serum level are controversial. We performed a comprehensive dose-response meta-analysis to evaluate the precise relationships between the above mentioned parameters.We performed a web search of the PubMed, Medline, and Embase databases to identify potential studies that evaluated the relationships between vitamin D intake or serum 25-hydroxyvitamin D (25([OH]D) levels and the risk of lung cancer on December 5, 2017. According to the inclusion and exclusive criteria, 16 studies were included in this meta-analysis. The pooled relative risks (RRs) with 95% confidence intervals (CIs) were used to assess the strength of the associations. A dose-response analysis was conducted to quantitate the relationship between the serum 25(OH)D or vitamin D intake and the risk of lung cancer.The pooled RR (highest level vs lowest level) showed that the serum 25(OH)D level was not associated with the risk of lung cancer (RR = 1.046, 95% CI = 0.945-1.159). A high vitamin D intake was inversely correlated with the lung cancer risk (RR = 0.854, 95% CI = 0.741-0.984). No significant dose-response relationship was observed between the serum 25(OH)D level and the lung cancer risk. The linearity model of the dose-response analysis indicated that with every 100 IU/day increase in vitamin D intake, the risk of lung cancer decreased by 2.4% (RR = 0.976, 95% CI = 0.957-0.995, P = .018).A high vitamin D intake provides limited protection against lung cancer carcinogenesis.

Authors+Show Affiliations

Department of Radiology, the Fifth Hospital of Wuhan.Department of Radiology, the Fifth Hospital of Wuhan.Department of Radiology, the Fifth Hospital of Wuhan.Department of Radiology, the Fifth Hospital of Wuhan.Department of Pathology, Renmin Hospital of Wuhan University, Wuhan, Hubei Province, People's Republic of China.

Pub Type(s)

Journal Article
Meta-Analysis
Review

Language

eng

PubMed ID

30212966

Citation

Wei, Hu, et al. "Associations of the Risk of Lung Cancer With Serum 25-hydroxyvitamin D Level and Dietary Vitamin D Intake: a Dose-response PRISMA Meta-analysis." Medicine, vol. 97, no. 37, 2018, pp. e12282.
Wei H, Jing H, Wei Q, et al. Associations of the risk of lung cancer with serum 25-hydroxyvitamin D level and dietary vitamin D intake: A dose-response PRISMA meta-analysis. Medicine (Baltimore). 2018;97(37):e12282.
Wei, H., Jing, H., Wei, Q., Wei, G., & Heng, Z. (2018). Associations of the risk of lung cancer with serum 25-hydroxyvitamin D level and dietary vitamin D intake: A dose-response PRISMA meta-analysis. Medicine, 97(37), pp. e12282. doi:10.1097/MD.0000000000012282.
Wei H, et al. Associations of the Risk of Lung Cancer With Serum 25-hydroxyvitamin D Level and Dietary Vitamin D Intake: a Dose-response PRISMA Meta-analysis. Medicine (Baltimore). 2018;97(37):e12282. PubMed PMID: 30212966.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Associations of the risk of lung cancer with serum 25-hydroxyvitamin D level and dietary vitamin D intake: A dose-response PRISMA meta-analysis. AU - Wei,Hu, AU - Jing,Hu, AU - Wei,Qian, AU - Wei,Guo, AU - Heng,Zhou, PY - 2018/9/15/entrez PY - 2018/9/15/pubmed PY - 2018/9/25/medline SP - e12282 EP - e12282 JF - Medicine JO - Medicine (Baltimore) VL - 97 IS - 37 N2 - The associations of the risk of lung cancer with the vitamin D intake and serum level are controversial. We performed a comprehensive dose-response meta-analysis to evaluate the precise relationships between the above mentioned parameters.We performed a web search of the PubMed, Medline, and Embase databases to identify potential studies that evaluated the relationships between vitamin D intake or serum 25-hydroxyvitamin D (25([OH]D) levels and the risk of lung cancer on December 5, 2017. According to the inclusion and exclusive criteria, 16 studies were included in this meta-analysis. The pooled relative risks (RRs) with 95% confidence intervals (CIs) were used to assess the strength of the associations. A dose-response analysis was conducted to quantitate the relationship between the serum 25(OH)D or vitamin D intake and the risk of lung cancer.The pooled RR (highest level vs lowest level) showed that the serum 25(OH)D level was not associated with the risk of lung cancer (RR = 1.046, 95% CI = 0.945-1.159). A high vitamin D intake was inversely correlated with the lung cancer risk (RR = 0.854, 95% CI = 0.741-0.984). No significant dose-response relationship was observed between the serum 25(OH)D level and the lung cancer risk. The linearity model of the dose-response analysis indicated that with every 100 IU/day increase in vitamin D intake, the risk of lung cancer decreased by 2.4% (RR = 0.976, 95% CI = 0.957-0.995, P = .018).A high vitamin D intake provides limited protection against lung cancer carcinogenesis. SN - 1536-5964 UR - https://www.unboundmedicine.com/medline/citation/30212966/Associations_of_the_risk_of_lung_cancer_with_serum_25_hydroxyvitamin_D_level_and_dietary_vitamin_D_intake:_A_dose_response_PRISMA_meta_analysis_ L2 - http://dx.doi.org/10.1097/MD.0000000000012282 DB - PRIME DP - Unbound Medicine ER -