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An Active Lifestyle Reinforces the Effect of a Healthy Diet on Cognitive Function: A Population-Based Longitudinal Study.
Nutrients. 2018 Sep 13; 10(9)N

Abstract

The joint effect of diet and leisure activity on cognitive function remains unknown. We aimed to verify the hypothesis that an active lifestyle reinforces the effect of the Nordic Prudent Dietary Pattern (NPDP) on cognitive function. A total of 2223 dementia-free Swedish adults aged ≥60 with Mini-Mental State Examination (MMSE) scores ≥27 were followed for an average of 6 years. MMSE was tested during follow-ups. Diet was assessed by food frequency questionnaire. The NPDP index was calculated and tertiled (low, moderate, and high adherence). Participation in physical, mental and social activities was trichotomised (low, moderate, and intense). An active lifestyle was defined based on the participation in each activity. Data were analyzed using mixed-effects models. Moderate-to-high adherence to NPDP was associated with a reduced decline in the MMSE score (β: 0.19, 95% Confidence Interval (CI): 0.14⁻0.24). This association became stronger when combined with moderate-to-intense physical (β: 0.34, 95% CI: 0.2⁻0.45), mental (β: 0.29, 95% CI: 0.21⁻0.37), or social (β: 0.27, 95% CI: 0.19⁻0.34) activities. An active lifestyle strengthened the effect of NPDP on cognitive function by two times, and further lowered risk of MMSE decline by 30%. Thus, an active lifestyle reinforces the effect of a healthy diet on preserved cognitive function, and further decreases the risk of cognitive decline.

Authors+Show Affiliations

Aging Research Center, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet/Stockholm University, Widerströmskahuset, plan 10, Tomtebodavägen 18A, 171 65 Solna, Sweden. behnaz.shakersain@ki.se.Aging Research Center, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet/Stockholm University, Widerströmskahuset, plan 10, Tomtebodavägen 18A, 171 65 Solna, Sweden. Debora.Rizzuto@ki.se.Aging Research Center, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet/Stockholm University, Widerströmskahuset, plan 10, Tomtebodavägen 18A, 171 65 Solna, Sweden. huixin.wang@su.se. Stress Research Institute, Stockholm University, 106 91 Stockholm, Sweden. huixin.wang@su.se.Division of Clinical Geriatrics, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, 141 57 Huddinge, Sweden. Gerd.Faxen.Irving@ki.se.Aging Research Center, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet/Stockholm University, Widerströmskahuset, plan 10, Tomtebodavägen 18A, 171 65 Solna, Sweden. federica.prinelli@ki.se. Institute of Biomedical Technologies-National Research Council Via Fratelli Cervi 93, 20090 Segrate (MI), Italy. federica.prinelli@ki.se.Aging Research Center, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet/Stockholm University, Widerströmskahuset, plan 10, Tomtebodavägen 18A, 171 65 Solna, Sweden. Laura.Fratiglioni@ki.se. Stockholm Gerontology Research Center, 113 30 Stockholm, Sweden. Laura.Fratiglioni@ki.se.Aging Research Center, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet/Stockholm University, Widerströmskahuset, plan 10, Tomtebodavägen 18A, 171 65 Solna, Sweden. weili.xu@ki.se. Department Epidemiology & Biostatistics, School of Public Health, Tianjin Medical University, 300070 Tianjin, China. weili.xu@ki.se.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

30217035

Citation

Shakersain, Behnaz, et al. "An Active Lifestyle Reinforces the Effect of a Healthy Diet On Cognitive Function: a Population-Based Longitudinal Study." Nutrients, vol. 10, no. 9, 2018.
Shakersain B, Rizzuto D, Wang HX, et al. An Active Lifestyle Reinforces the Effect of a Healthy Diet on Cognitive Function: A Population-Based Longitudinal Study. Nutrients. 2018;10(9).
Shakersain, B., Rizzuto, D., Wang, H. X., Faxén-Irving, G., Prinelli, F., Fratiglioni, L., & Xu, W. (2018). An Active Lifestyle Reinforces the Effect of a Healthy Diet on Cognitive Function: A Population-Based Longitudinal Study. Nutrients, 10(9). https://doi.org/10.3390/nu10091297
Shakersain B, et al. An Active Lifestyle Reinforces the Effect of a Healthy Diet On Cognitive Function: a Population-Based Longitudinal Study. Nutrients. 2018 Sep 13;10(9) PubMed PMID: 30217035.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - An Active Lifestyle Reinforces the Effect of a Healthy Diet on Cognitive Function: A Population-Based Longitudinal Study. AU - Shakersain,Behnaz, AU - Rizzuto,Debora, AU - Wang,Hui-Xin, AU - Faxén-Irving,Gerd, AU - Prinelli,Federica, AU - Fratiglioni,Laura, AU - Xu,Weili, Y1 - 2018/09/13/ PY - 2018/08/17/received PY - 2018/09/10/revised PY - 2018/09/11/accepted PY - 2018/9/16/entrez PY - 2018/9/16/pubmed PY - 2018/12/19/medline KW - active life style KW - cognitive function KW - leisure activities KW - population-based cohort study KW - the Nordic Prudent Dietary Pattern JF - Nutrients JO - Nutrients VL - 10 IS - 9 N2 - The joint effect of diet and leisure activity on cognitive function remains unknown. We aimed to verify the hypothesis that an active lifestyle reinforces the effect of the Nordic Prudent Dietary Pattern (NPDP) on cognitive function. A total of 2223 dementia-free Swedish adults aged ≥60 with Mini-Mental State Examination (MMSE) scores ≥27 were followed for an average of 6 years. MMSE was tested during follow-ups. Diet was assessed by food frequency questionnaire. The NPDP index was calculated and tertiled (low, moderate, and high adherence). Participation in physical, mental and social activities was trichotomised (low, moderate, and intense). An active lifestyle was defined based on the participation in each activity. Data were analyzed using mixed-effects models. Moderate-to-high adherence to NPDP was associated with a reduced decline in the MMSE score (β: 0.19, 95% Confidence Interval (CI): 0.14⁻0.24). This association became stronger when combined with moderate-to-intense physical (β: 0.34, 95% CI: 0.2⁻0.45), mental (β: 0.29, 95% CI: 0.21⁻0.37), or social (β: 0.27, 95% CI: 0.19⁻0.34) activities. An active lifestyle strengthened the effect of NPDP on cognitive function by two times, and further lowered risk of MMSE decline by 30%. Thus, an active lifestyle reinforces the effect of a healthy diet on preserved cognitive function, and further decreases the risk of cognitive decline. SN - 2072-6643 UR - https://www.unboundmedicine.com/medline/citation/30217035/An_Active_Lifestyle_Reinforces_the_Effect_of_a_Healthy_Diet_on_Cognitive_Function:_A_Population_Based_Longitudinal_Study_ L2 - http://www.mdpi.com/resolver?pii=nu10091297 DB - PRIME DP - Unbound Medicine ER -