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Assessment of nail unit structures by ultrasound in patients with psoriatic arthritis and their correlations with disease activity indices: a case-control study.
Rheumatol Int. 2018 11; 38(11):2087-2093.RI

Abstract

Ultrasound (USG) of nail was performed to assess, (1) morphological alterations of nail plates in psoriatic arthritis (PsA) patients, (2) differences of nail unit parameters [nail bed thickness (NBT), nail matrix thickness (NMT) and nail plate distance (NPD)] in PsA patients from healthy controls (3) correlation of nail unit parameters with PsA disease activity indices. Total of 895 fingernails (448 nails of 45 PsA patients and 447 of 45 controls) were evaluated by USG. Psoriasis Area and Severity Index (PASI), Disease Activity in Psoriatic Arthritis (DAPSA), and Nail Psoriasis Severity Index (NAPSI) were calculated in PsA patients. Nail unit parameters were compared between two study groups. Correlation study was done between nail unit parameters and disease activity indices. All PsA patients showed ultrasound evidence of nail plate changes (87.95% of the total fingernails and 75.34% of the clinically normal nails). Loosening of the ventral nail plate border was most common (51.79%). Mean NBT (PsA: 0.19 ± 0.035 cm, control: 0.17 ± 0.018 cm, p = 0.003) and mean NMT (PsA: 0.32 ± 0.041 cm, control: 0.28 ± 0.031 cm, p = < 0.0001) were significantly increased in the PsA patients. Moderately positive correlation was observed between NAPSI score and mean NMT (Spearman r = 0.411, 95% confidence interval: 0.125-0.634, p = 0.005). USG evidence of nail plate alterations was frequent among PsA patients, even in clinically normal nails. Increased mean nail bed and matrix thickness were noted in PsA patients. Mean NMT had a moderately positive correlation with NAPSI score.

Authors+Show Affiliations

Department of Rheumatology, Institute of Post Graduate Medical Education and Research, Doctor's hostel. 242 A J C Bose Road, Kolkata, West Bengal, 700020, India. drmsumantro@gmail.com.Department of Rheumatology, Institute of Post Graduate Medical Education and Research, Doctor's hostel. 242 A J C Bose Road, Kolkata, West Bengal, 700020, India.Department of Rheumatology, Institute of Post Graduate Medical Education and Research, Doctor's hostel. 242 A J C Bose Road, Kolkata, West Bengal, 700020, India.Department of Rheumatology, Institute of Post Graduate Medical Education and Research, Doctor's hostel. 242 A J C Bose Road, Kolkata, West Bengal, 700020, India.Department of Rheumatology, Institute of Post Graduate Medical Education and Research, Doctor's hostel. 242 A J C Bose Road, Kolkata, West Bengal, 700020, India.Department of Dermatology, Institute of Post Graduate Medical Education and Research, Kolkata, India.Department of Dermatology, Institute of Post Graduate Medical Education and Research, Kolkata, India.Department of Rheumatology, Institute of Post Graduate Medical Education and Research, Doctor's hostel. 242 A J C Bose Road, Kolkata, West Bengal, 700020, India.

Pub Type(s)

Journal Article
Observational Study

Language

eng

PubMed ID

30225658

Citation

Mondal, Sumantro, et al. "Assessment of Nail Unit Structures By Ultrasound in Patients With Psoriatic Arthritis and Their Correlations With Disease Activity Indices: a Case-control Study." Rheumatology International, vol. 38, no. 11, 2018, pp. 2087-2093.
Mondal S, Dutta S, Lahiri D, et al. Assessment of nail unit structures by ultrasound in patients with psoriatic arthritis and their correlations with disease activity indices: a case-control study. Rheumatol Int. 2018;38(11):2087-2093.
Mondal, S., Dutta, S., Lahiri, D., Sinha, D., Sircar, G., Mandal, A. K., Kejriwal, M., & Ghosh, A. (2018). Assessment of nail unit structures by ultrasound in patients with psoriatic arthritis and their correlations with disease activity indices: a case-control study. Rheumatology International, 38(11), 2087-2093. https://doi.org/10.1007/s00296-018-4160-8
Mondal S, et al. Assessment of Nail Unit Structures By Ultrasound in Patients With Psoriatic Arthritis and Their Correlations With Disease Activity Indices: a Case-control Study. Rheumatol Int. 2018;38(11):2087-2093. PubMed PMID: 30225658.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Assessment of nail unit structures by ultrasound in patients with psoriatic arthritis and their correlations with disease activity indices: a case-control study. AU - Mondal,Sumantro, AU - Dutta,Satarupa, AU - Lahiri,Debasish, AU - Sinha,Debanjali, AU - Sircar,Geetabali, AU - Mandal,Ashok Kumar, AU - Kejriwal,Megha, AU - Ghosh,Alakendu, Y1 - 2018/09/17/ PY - 2018/07/27/received PY - 2018/09/12/accepted PY - 2018/9/19/pubmed PY - 2019/10/2/medline PY - 2018/9/19/entrez KW - Nail KW - Psoriatic arthritis KW - Ultrasonography SP - 2087 EP - 2093 JF - Rheumatology international JO - Rheumatol. Int. VL - 38 IS - 11 N2 - Ultrasound (USG) of nail was performed to assess, (1) morphological alterations of nail plates in psoriatic arthritis (PsA) patients, (2) differences of nail unit parameters [nail bed thickness (NBT), nail matrix thickness (NMT) and nail plate distance (NPD)] in PsA patients from healthy controls (3) correlation of nail unit parameters with PsA disease activity indices. Total of 895 fingernails (448 nails of 45 PsA patients and 447 of 45 controls) were evaluated by USG. Psoriasis Area and Severity Index (PASI), Disease Activity in Psoriatic Arthritis (DAPSA), and Nail Psoriasis Severity Index (NAPSI) were calculated in PsA patients. Nail unit parameters were compared between two study groups. Correlation study was done between nail unit parameters and disease activity indices. All PsA patients showed ultrasound evidence of nail plate changes (87.95% of the total fingernails and 75.34% of the clinically normal nails). Loosening of the ventral nail plate border was most common (51.79%). Mean NBT (PsA: 0.19 ± 0.035 cm, control: 0.17 ± 0.018 cm, p = 0.003) and mean NMT (PsA: 0.32 ± 0.041 cm, control: 0.28 ± 0.031 cm, p = < 0.0001) were significantly increased in the PsA patients. Moderately positive correlation was observed between NAPSI score and mean NMT (Spearman r = 0.411, 95% confidence interval: 0.125-0.634, p = 0.005). USG evidence of nail plate alterations was frequent among PsA patients, even in clinically normal nails. Increased mean nail bed and matrix thickness were noted in PsA patients. Mean NMT had a moderately positive correlation with NAPSI score. SN - 1437-160X UR - https://www.unboundmedicine.com/medline/citation/30225658/Assessment_of_nail_unit_structures_by_ultrasound_in_patients_with_psoriatic_arthritis_and_their_correlations_with_disease_activity_indices:_a_case_control_study_ L2 - https://dx.doi.org/10.1007/s00296-018-4160-8 DB - PRIME DP - Unbound Medicine ER -