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Experimental allergic encephalomyelitis: enhancement of cell-mediated transfer by concanavalin A.
J Immunol. 1977 Sep; 119(3):1134-7.JI

Abstract

Adoptive transfer of experimental allergic encephalomyelitis (EAE) with splenic lymphocytes from Lewis rats sensitized to myelin basic protein (BP) was potentiated by incubation of the cells in vitro with concanavalin A (Con A). Spleen cells of donors which had recovered from EAE also transferred the disease readily after activation by this procedure. In contrast, the transfer of activity of lymph node cells was not altered. We conclude that during the course of EAE a population of T cells with immunologic memory for BP is generated and persists in the spleen. Incubation with Con A activates these cells and results in marked enhancement of their ability to transfer the disease.

Authors

No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

302272

Citation

Panitch, H S., and D E. McFarlin. "Experimental Allergic Encephalomyelitis: Enhancement of Cell-mediated Transfer By Concanavalin A." Journal of Immunology (Baltimore, Md. : 1950), vol. 119, no. 3, 1977, pp. 1134-7.
Panitch HS, McFarlin DE. Experimental allergic encephalomyelitis: enhancement of cell-mediated transfer by concanavalin A. J Immunol. 1977;119(3):1134-7.
Panitch, H. S., & McFarlin, D. E. (1977). Experimental allergic encephalomyelitis: enhancement of cell-mediated transfer by concanavalin A. Journal of Immunology (Baltimore, Md. : 1950), 119(3), 1134-7.
Panitch HS, McFarlin DE. Experimental Allergic Encephalomyelitis: Enhancement of Cell-mediated Transfer By Concanavalin A. J Immunol. 1977;119(3):1134-7. PubMed PMID: 302272.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Experimental allergic encephalomyelitis: enhancement of cell-mediated transfer by concanavalin A. AU - Panitch,H S, AU - McFarlin,D E, PY - 1977/9/1/pubmed PY - 1977/9/1/medline PY - 1977/9/1/entrez SP - 1134 EP - 7 JF - Journal of immunology (Baltimore, Md. : 1950) JO - J Immunol VL - 119 IS - 3 N2 - Adoptive transfer of experimental allergic encephalomyelitis (EAE) with splenic lymphocytes from Lewis rats sensitized to myelin basic protein (BP) was potentiated by incubation of the cells in vitro with concanavalin A (Con A). Spleen cells of donors which had recovered from EAE also transferred the disease readily after activation by this procedure. In contrast, the transfer of activity of lymph node cells was not altered. We conclude that during the course of EAE a population of T cells with immunologic memory for BP is generated and persists in the spleen. Incubation with Con A activates these cells and results in marked enhancement of their ability to transfer the disease. SN - 0022-1767 UR - https://www.unboundmedicine.com/medline/citation/302272/Experimental_allergic_encephalomyelitis:_enhancement_of_cell_mediated_transfer_by_concanavalin_A_ L2 - https://www.jimmunol.org/lookup/pmidlookup?view=long&pmid=302272 DB - PRIME DP - Unbound Medicine ER -