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New Cytotoxic Cycloartane Triterpenes from the Aerial Parts of Actaea heracleifolia (syn. Cimicifuga heracleifolia).
Planta Med. 2019 Jan; 85(2):154-159.PM

Abstract

One new 15,16-seco-cycloartane triterpene (1:), three new cycloartane triterpene glycosides (2: -4:), and five known compounds (5: -9:) were isolated from the aerial parts of Actaea heracleifolia. The chemical structures of these compounds were determined on the basis of NMR analysis, HRTOF-ESIMS data, and other spectroscopic methods. Selected compounds were evaluated for their cytotoxicity against human tumor cell lines (HL-60, SMMC-7721, A549, MCF-7, and SW480) in vitro. Compounds 3: and 4: showed weak activity against the HL-60, A-549, and MCF-7 cell lines with IC50 values ranging from 21.34 to 36.98 µM.

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Publisher Full Text (DOI)

Authors+Show Affiliations

Shi QQ
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Science, Kunming, China. University of the Chinese Academy of Science, Beijing, China. Yunnan Key Laboratory of Natural Medicinal Chemistry Chinese Academy of Sciences, Kunming, China.
Wang WH
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Science, Kunming, China. University of the Chinese Academy of Science, Beijing, China. Yunnan Key Laboratory of Natural Medicinal Chemistry Chinese Academy of Sciences, Kunming, China.
Lu J
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Science, Kunming, China. University of the Chinese Academy of Science, Beijing, China. Yunnan Key Laboratory of Natural Medicinal Chemistry Chinese Academy of Sciences, Kunming, China.
Li DS
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Science, Kunming, China. Yunnan Key Laboratory of Natural Medicinal Chemistry Chinese Academy of Sciences, Kunming, China.
Zhou L
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Science, Kunming, China. Yunnan Key Laboratory of Natural Medicinal Chemistry Chinese Academy of Sciences, Kunming, China.
Qiu MH
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Science, Kunming, China. Yunnan Key Laboratory of Natural Medicinal Chemistry Chinese Academy of Sciences, Kunming, China.

MeSH

ActaeaAntineoplastic AgentsCell Line, TumorHumansMagnetic Resonance SpectroscopyPlant LeavesPlant StemsTriterpenes

Pub Type(s)

Journal Article

Language

eng

PubMed ID

30231263

Citation

Shi, Qiang-Qiang, et al. "New Cytotoxic Cycloartane Triterpenes From the Aerial Parts of Actaea Heracleifolia (syn. Cimicifuga Heracleifolia)." Planta Medica, vol. 85, no. 2, 2019, pp. 154-159.
Shi QQ, Wang WH, Lu J, et al. New Cytotoxic Cycloartane Triterpenes from the Aerial Parts of Actaea heracleifolia (syn. Cimicifuga heracleifolia). Planta Med. 2019;85(2):154-159.
Shi, Q. Q., Wang, W. H., Lu, J., Li, D. S., Zhou, L., & Qiu, M. H. (2019). New Cytotoxic Cycloartane Triterpenes from the Aerial Parts of Actaea heracleifolia (syn. Cimicifuga heracleifolia). Planta Medica, 85(2), 154-159. https://doi.org/10.1055/a-0733-7229
Shi QQ, et al. New Cytotoxic Cycloartane Triterpenes From the Aerial Parts of Actaea Heracleifolia (syn. Cimicifuga Heracleifolia). Planta Med. 2019;85(2):154-159. PubMed PMID: 30231263.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - New Cytotoxic Cycloartane Triterpenes from the Aerial Parts of Actaea heracleifolia (syn. Cimicifuga heracleifolia). AU - Shi,Qiang-Qiang, AU - Wang,Wei-Hua, AU - Lu,Jing, AU - Li,Da-Shan, AU - Zhou,Lin, AU - Qiu,Ming-Hua, Y1 - 2018/09/19/ PY - 2018/9/20/pubmed PY - 2019/2/2/medline PY - 2018/9/20/entrez SP - 154 EP - 159 JF - Planta medica JO - Planta Med VL - 85 IS - 2 N2 - One new 15,16-seco-cycloartane triterpene (1:), three new cycloartane triterpene glycosides (2: -4:), and five known compounds (5: -9:) were isolated from the aerial parts of Actaea heracleifolia. The chemical structures of these compounds were determined on the basis of NMR analysis, HRTOF-ESIMS data, and other spectroscopic methods. Selected compounds were evaluated for their cytotoxicity against human tumor cell lines (HL-60, SMMC-7721, A549, MCF-7, and SW480) in vitro. Compounds 3: and 4: showed weak activity against the HL-60, A-549, and MCF-7 cell lines with IC50 values ranging from 21.34 to 36.98 µM. SN - 1439-0221 UR - https://www.unboundmedicine.com/medline/citation/30231263/New_Cytotoxic_Cycloartane_Triterpenes_from_the_Aerial_Parts_of_Actaea_heracleifolia__syn__Cimicifuga_heracleifolia__ DB - PRIME DP - Unbound Medicine ER -