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A Paradigmatic Interplay between Human Cytomegalovirus and Host Immune System: Possible Involvement of Viral Antigen-Driven CD8+ T Cell Responses in Systemic Sclerosis.
Viruses. 2018 09 18; 10(9)V

Abstract

Human cytomegalovirus (HCMV) is a highly prevalent opportunistic agent in the world population, which persists as a latent virus after a primary infection. Besides the well-established role of this agent causing severe diseases in immunocompromised individuals, more recently, HCMV has been evoked as a possible factor contributing to the pathogenesis of autoimmune diseases such as systemic sclerosis (SSc). The interplay between HCMV and immune surveillance is supposed to become unbalanced in SSc patients with expanded anti-HCMV immune responses, which are likely involved in the exacerbation of inflammatory processes. In this study, blood samples from a cohort of SSc patients vs. healthy subjects were tested for anti-HCMV immune responses (IgM, IgG antibodies, and T cells to peptide pools spanning the most immunogenic HCMV proteins). Statistically significant increase of HCMV-specific CD8+ T cell responses in SSc patients vs. healthy subjects was observed. Moreover, significantly greater HCMV-specific CD8+ T cell responses were found in SSc patients with a longer disease duration and those with higher modified Rodnan skin scores. Given the known importance of T cells in the development of SSc and that this virus may contribute to chronic inflammatory diseases, these data support a relevant role of HCMV-specific CD8+ T cell responses in SSc pathogenesis.

Links

Publisher Full Text
ncbi.nlm.nih.gov
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Authors+Show Affiliations

Arcangeletti MC
Virology Unit, University-Hospital of Parma, Department of Medicine and Surgery, University of Parma, 43126 Parma, Italy. mariacristina.arcangeletti@unipr.it.
Maccari C
Virology Unit, University-Hospital of Parma, Department of Medicine and Surgery, University of Parma, 43126 Parma, Italy. clara.maccari@studenti.unipr.it.
Vescovini R
Department of Medicine and Surgery, University of Parma, 43126 Parma, Italy. rosanna.vescovini@unipr.it.
Volpi R
Department of Medicine and Surgery, University of Parma, 43126 Parma, Italy. riccardo.volpi@unipr.it.
Giuggioli D
Rheumatology Unit, Medical School, University of Modena and Reggio Emilia, University-Hospital Policlinico of Modena, 41121 Modena, Italy. giuggioli.dilia@policlinico.mo.it.
Sighinolfi G
Rheumatology Unit, Medical School, University of Modena and Reggio Emilia, University-Hospital Policlinico of Modena, 41121 Modena, Italy. gianluca.sighinolfi@gmail.com.
De Conto F
Virology Unit, University-Hospital of Parma, Department of Medicine and Surgery, University of Parma, 43126 Parma, Italy. flora.deconto@unipr.it.
Chezzi C
Virology Unit, University-Hospital of Parma, Department of Medicine and Surgery, University of Parma, 43126 Parma, Italy. carlo.chezzi@unipr.it.
Calderaro A
Virology Unit, University-Hospital of Parma, Department of Medicine and Surgery, University of Parma, 43126 Parma, Italy. adriana.calderaro@unipr.it.
Ferri C
Rheumatology Unit, Medical School, University of Modena and Reggio Emilia, University-Hospital Policlinico of Modena, 41121 Modena, Italy. clodoveo.ferri@unimore.it.

MeSH

AdultAgedAntibodies, ViralAntigens, ViralCD4-Positive T-LymphocytesCD8-Positive T-LymphocytesCytomegalovirusCytomegalovirus InfectionsFemaleHost-Pathogen InteractionsHumansMaleMiddle AgedScleroderma, SystemicSkin

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

30231575

Citation

Arcangeletti, Maria-Cristina, et al. "A Paradigmatic Interplay Between Human Cytomegalovirus and Host Immune System: Possible Involvement of Viral Antigen-Driven CD8+ T Cell Responses in Systemic Sclerosis." Viruses, vol. 10, no. 9, 2018.
Arcangeletti MC, Maccari C, Vescovini R, et al. A Paradigmatic Interplay between Human Cytomegalovirus and Host Immune System: Possible Involvement of Viral Antigen-Driven CD8+ T Cell Responses in Systemic Sclerosis. Viruses. 2018;10(9).
Arcangeletti, M. C., Maccari, C., Vescovini, R., Volpi, R., Giuggioli, D., Sighinolfi, G., De Conto, F., Chezzi, C., Calderaro, A., & Ferri, C. (2018). A Paradigmatic Interplay between Human Cytomegalovirus and Host Immune System: Possible Involvement of Viral Antigen-Driven CD8+ T Cell Responses in Systemic Sclerosis. Viruses, 10(9). https://doi.org/10.3390/v10090508
Arcangeletti MC, et al. A Paradigmatic Interplay Between Human Cytomegalovirus and Host Immune System: Possible Involvement of Viral Antigen-Driven CD8+ T Cell Responses in Systemic Sclerosis. Viruses. 2018 09 18;10(9) PubMed PMID: 30231575.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A Paradigmatic Interplay between Human Cytomegalovirus and Host Immune System: Possible Involvement of Viral Antigen-Driven CD8+ T Cell Responses in Systemic Sclerosis. AU - Arcangeletti,Maria-Cristina, AU - Maccari,Clara, AU - Vescovini,Rosanna, AU - Volpi,Riccardo, AU - Giuggioli,Dilia, AU - Sighinolfi,Gianluca, AU - De Conto,Flora, AU - Chezzi,Carlo, AU - Calderaro,Adriana, AU - Ferri,Clodoveo, Y1 - 2018/09/18/ PY - 2018/08/30/received PY - 2018/09/12/revised PY - 2018/09/14/accepted PY - 2018/9/21/entrez PY - 2018/9/21/pubmed PY - 2018/11/18/medline KW - antigen-driven T cell responses KW - disease duration KW - human cytomegalovirus KW - modified Rodnan skin score KW - systemic sclerosis KW - virus-host interactions JF - Viruses JO - Viruses VL - 10 IS - 9 N2 - Human cytomegalovirus (HCMV) is a highly prevalent opportunistic agent in the world population, which persists as a latent virus after a primary infection. Besides the well-established role of this agent causing severe diseases in immunocompromised individuals, more recently, HCMV has been evoked as a possible factor contributing to the pathogenesis of autoimmune diseases such as systemic sclerosis (SSc). The interplay between HCMV and immune surveillance is supposed to become unbalanced in SSc patients with expanded anti-HCMV immune responses, which are likely involved in the exacerbation of inflammatory processes. In this study, blood samples from a cohort of SSc patients vs. healthy subjects were tested for anti-HCMV immune responses (IgM, IgG antibodies, and T cells to peptide pools spanning the most immunogenic HCMV proteins). Statistically significant increase of HCMV-specific CD8+ T cell responses in SSc patients vs. healthy subjects was observed. Moreover, significantly greater HCMV-specific CD8+ T cell responses were found in SSc patients with a longer disease duration and those with higher modified Rodnan skin scores. Given the known importance of T cells in the development of SSc and that this virus may contribute to chronic inflammatory diseases, these data support a relevant role of HCMV-specific CD8+ T cell responses in SSc pathogenesis. SN - 1999-4915 UR - https://www.unboundmedicine.com/medline/citation/30231575/A_Paradigmatic_Interplay_between_Human_Cytomegalovirus_and_Host_Immune_System:_Possible_Involvement_of_Viral_Antigen_Driven_CD8+_T_Cell_Responses_in_Systemic_Sclerosis_ L2 - https://www.mdpi.com/resolver?pii=v10090508 DB - PRIME DP - Unbound Medicine ER -