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Effect of Physical Exercise on Endometriosis Experimentally Induced in Rats.

Abstract

OBJECTIVE

Endometriosis is characterized by the growth of endometrial tissue outside the uterine cavity. The prevalence of endometriosis among women experiencing pain, infertility, or both is as high as 35% to 50%. The most common symptoms of endometriosis are dysmenorrhea, dyspareunia, chronic pelvic pain, and infertility. Evidence has suggested that endometriosis symptoms result from a local inflammatory peritoneal reaction caused by ectopic endometrial implants that undergo cyclic bleeding. On the other hand, regular physical exercise seems to have protective effects against diseases that involve inflammatory processes such as type 2 diabetes and colon and breast cancer. On this basis, it is possible that the practice of physical exercise may have beneficial effects on endometriosis. Therefore, the objective of this study was to evaluate the possible anti-inflammatory effect of physical exercise on endometriosis experimentally induced in rats.

STUDY DESIGN

Seventy female Wistar rats were divided into 7groups of 10 animals each. Animals performed light exercise (swimming once a week), moderate exercise (swimming 3 times a week), and intense exercise (swimming 5 times a week) before or after endometriosis induction.

RESULTS

At the end of the experimental protocol, a reduction in the size of endometriotic lesions was observed after physical exercise regardless of its frequency, with a greater reduction in the groups practicing moderate and intense activity; an increase in FAS levels and a decrease in matrix metalloproteinases 9 and proliferating cell nuclear antigen (PCNA)levels was also observed. The immunohistochemistry results did not lead to conclusive results. As expected, oxidative stress was reduced in all groups. These results show that the practice of physical exercise could be beneficial, at least in part, for the treatment of endometriosis.

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  • Authors+Show Affiliations

    ,

    1 Department of Gynecology and Obstetrics, Faculty of Medicine of Ribeirao Preto, University of Sao Paulo, São Paulo, Brazil.

    ,

    1 Department of Gynecology and Obstetrics, Faculty of Medicine of Ribeirao Preto, University of Sao Paulo, São Paulo, Brazil.

    ,

    1 Department of Gynecology and Obstetrics, Faculty of Medicine of Ribeirao Preto, University of Sao Paulo, São Paulo, Brazil.

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    2 Department of Pharmacology, Faculty of Medicine of Ribeirao Preto, University of Sao Paulo, São Paulo, Brazil.

    ,

    3 Department of Pathology, Faculty of Medicine of Ribeirao Preto, University of Sao Paulo, São Paulo, Brazil.

    ,

    3 Department of Pathology, Faculty of Medicine of Ribeirao Preto, University of Sao Paulo, São Paulo, Brazil.

    ,

    1 Department of Gynecology and Obstetrics, Faculty of Medicine of Ribeirao Preto, University of Sao Paulo, São Paulo, Brazil.

    1 Department of Gynecology and Obstetrics, Faculty of Medicine of Ribeirao Preto, University of Sao Paulo, São Paulo, Brazil.

    Source

    Reproductive sciences (Thousand Oaks, Calif.) : 2018 Sep 19 pg 1933719118799205

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    30231769

    Citation

    Montenegro, Mary Lourdes, et al. "Effect of Physical Exercise On Endometriosis Experimentally Induced in Rats." Reproductive Sciences (Thousand Oaks, Calif.), 2018, p. 1933719118799205.
    Montenegro ML, Bonocher CM, Meola J, et al. Effect of Physical Exercise on Endometriosis Experimentally Induced in Rats. Reprod Sci. 2018.
    Montenegro, M. L., Bonocher, C. M., Meola, J., Portella, R. L., Ribeiro-Silva, A., Brunaldi, M. O., ... Rosa-E-Silva, J. C. (2018). Effect of Physical Exercise on Endometriosis Experimentally Induced in Rats. Reproductive Sciences (Thousand Oaks, Calif.), p. 1933719118799205. doi:10.1177/1933719118799205.
    Montenegro ML, et al. Effect of Physical Exercise On Endometriosis Experimentally Induced in Rats. Reprod Sci. 2018 Sep 19;1933719118799205. PubMed PMID: 30231769.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Effect of Physical Exercise on Endometriosis Experimentally Induced in Rats. AU - Montenegro,Mary Lourdes, AU - Bonocher,Camila M, AU - Meola,Juliana, AU - Portella,Rafael L, AU - Ribeiro-Silva,Alfredo, AU - Brunaldi,Mariangela O, AU - Ferriani,Rui Alberto, AU - Rosa-E-Silva,Julio Cesar, Y1 - 2018/09/19/ PY - 2018/9/21/entrez PY - 2018/9/21/pubmed PY - 2018/9/21/medline KW - endometriosis KW - physical exercise KW - swimming KW - treatment SP - 1933719118799205 EP - 1933719118799205 JF - Reproductive sciences (Thousand Oaks, Calif.) JO - Reprod Sci N2 - OBJECTIVE: Endometriosis is characterized by the growth of endometrial tissue outside the uterine cavity. The prevalence of endometriosis among women experiencing pain, infertility, or both is as high as 35% to 50%. The most common symptoms of endometriosis are dysmenorrhea, dyspareunia, chronic pelvic pain, and infertility. Evidence has suggested that endometriosis symptoms result from a local inflammatory peritoneal reaction caused by ectopic endometrial implants that undergo cyclic bleeding. On the other hand, regular physical exercise seems to have protective effects against diseases that involve inflammatory processes such as type 2 diabetes and colon and breast cancer. On this basis, it is possible that the practice of physical exercise may have beneficial effects on endometriosis. Therefore, the objective of this study was to evaluate the possible anti-inflammatory effect of physical exercise on endometriosis experimentally induced in rats. STUDY DESIGN: Seventy female Wistar rats were divided into 7groups of 10 animals each. Animals performed light exercise (swimming once a week), moderate exercise (swimming 3 times a week), and intense exercise (swimming 5 times a week) before or after endometriosis induction. RESULTS: At the end of the experimental protocol, a reduction in the size of endometriotic lesions was observed after physical exercise regardless of its frequency, with a greater reduction in the groups practicing moderate and intense activity; an increase in FAS levels and a decrease in matrix metalloproteinases 9 and proliferating cell nuclear antigen (PCNA)levels was also observed. The immunohistochemistry results did not lead to conclusive results. As expected, oxidative stress was reduced in all groups. These results show that the practice of physical exercise could be beneficial, at least in part, for the treatment of endometriosis. SN - 1933-7205 UR - https://www.unboundmedicine.com/medline/citation/30231769/Effect_of_Physical_Exercise_on_Endometriosis_Experimentally_Induced_in_Rats_ L2 - http://journals.sagepub.com/doi/full/10.1177/1933719118799205?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -