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Degree centrality and voxel-mirrored homotopic connectivity in children with nocturnal enuresis: A functional MRI study.
Neurol India. 2018 Sep-Oct; 66(5):1359-1364.NI

Abstract

Aim

To determine the characteristics of brain development in children with nocturnal enuresis, we investigated the intensity of functional connectivity both among the nodes in the brain network and between the two hemispheres of the brain.

Materials and Methods

Twenty-three children with nocturnal enuresis (NE) and an equal number of normal children were examined using resting-state functional magnetic resonance imaging (fMRI) scans. Data analysis was done via the degree centrality (DC) and voxel-mirrored homotopic connectivity (VMHC) approaches. Moreover, we compared the children's psychological status by utilizing the self-concept scale.

Results

In four areas of the brain, the the DC values of the NE group were obviously lower than that of the normal controls. These four areas were the posterior cerebellar lobe, anterior cingulate cortex (ACC), medial frontal gyrus, and superior left temporal gyrus (P < 0.05, after correction). We also found two brain areas where the VMHC values of the NE group were obviously lower than that of the normal controls. The two groups were the cerebellar lobe and the anterior cingulate cortex (ACC) [P < 0.05, after correction]. A psychological comparison between the children with NE and that in the normal group on the self-concept scale was also performed. The scores of the children with NE were lower than normal controls regarding behavior, appearance and property, anxiety, gregariousness, happiness, and satisfaction (P < 0.05).

Conclusions

These findings provide evidence of the deficit of urination control in children with NE. Furthermore, through the methods of DC and VMHC, which are based on functional connectivity, it was also possible to explain why children with NE often have the concomitant symptoms of attention, control, and memory problems. The analysis of the self-concept scale suggests that children with NE lack self-confidence.

Authors+Show Affiliations

Children's Health Research Center, Changzhou Children's Hospital, Changzhou, China.Children's Health Research Center, Changzhou Children's Hospital, Changzhou, China.Children's Health Research Center, Changzhou Children's Hospital, Changzhou, China.Children's Health Research Center, Changzhou Children's Hospital, Changzhou, China.Children's Health Research Center, Changzhou Children's Hospital, Changzhou, China.Children's Health Research Center, Changzhou Children's Hospital, Changzhou, China.Children's Health Research Center, Changzhou Children's Hospital, Changzhou, China.Children's Health Research Center, Changzhou Children's Hospital, Changzhou, China.Institut National de Recherche en Informatique et en Automatique (INRIA), Saclay, France.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

30233003

Citation

Jiang, Kaihua, et al. "Degree Centrality and Voxel-mirrored Homotopic Connectivity in Children With Nocturnal Enuresis: a Functional MRI Study." Neurology India, vol. 66, no. 5, 2018, pp. 1359-1364.
Jiang K, Ding L, Li H, et al. Degree centrality and voxel-mirrored homotopic connectivity in children with nocturnal enuresis: A functional MRI study. Neurol India. 2018;66(5):1359-1364.
Jiang, K., Ding, L., Li, H., Shen, H., Zheng, A., Zhao, F., Gao, M., Dong, X., & Yu, S. (2018). Degree centrality and voxel-mirrored homotopic connectivity in children with nocturnal enuresis: A functional MRI study. Neurology India, 66(5), 1359-1364. https://doi.org/10.4103/0028-3886.241334
Jiang K, et al. Degree Centrality and Voxel-mirrored Homotopic Connectivity in Children With Nocturnal Enuresis: a Functional MRI Study. Neurol India. 2018 Sep-Oct;66(5):1359-1364. PubMed PMID: 30233003.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Degree centrality and voxel-mirrored homotopic connectivity in children with nocturnal enuresis: A functional MRI study. AU - Jiang,Kaihua, AU - Ding,Li, AU - Li,Hongxin, AU - Shen,Huijuan, AU - Zheng,Aibin, AU - Zhao,Fangqiao, AU - Gao,Min, AU - Dong,Xuan, AU - Yu,Shan, PY - 2018/9/21/entrez PY - 2018/9/21/pubmed PY - 2019/9/21/medline KW - Children KW - degree centrality KW - fMRI KW - nocturnal enuresis KW - voxel-mirrored homotopic connectivity SP - 1359 EP - 1364 JF - Neurology India JO - Neurol India VL - 66 IS - 5 N2 - Aim: To determine the characteristics of brain development in children with nocturnal enuresis, we investigated the intensity of functional connectivity both among the nodes in the brain network and between the two hemispheres of the brain. Materials and Methods: Twenty-three children with nocturnal enuresis (NE) and an equal number of normal children were examined using resting-state functional magnetic resonance imaging (fMRI) scans. Data analysis was done via the degree centrality (DC) and voxel-mirrored homotopic connectivity (VMHC) approaches. Moreover, we compared the children's psychological status by utilizing the self-concept scale. Results: In four areas of the brain, the the DC values of the NE group were obviously lower than that of the normal controls. These four areas were the posterior cerebellar lobe, anterior cingulate cortex (ACC), medial frontal gyrus, and superior left temporal gyrus (P < 0.05, after correction). We also found two brain areas where the VMHC values of the NE group were obviously lower than that of the normal controls. The two groups were the cerebellar lobe and the anterior cingulate cortex (ACC) [P < 0.05, after correction]. A psychological comparison between the children with NE and that in the normal group on the self-concept scale was also performed. The scores of the children with NE were lower than normal controls regarding behavior, appearance and property, anxiety, gregariousness, happiness, and satisfaction (P < 0.05). Conclusions: These findings provide evidence of the deficit of urination control in children with NE. Furthermore, through the methods of DC and VMHC, which are based on functional connectivity, it was also possible to explain why children with NE often have the concomitant symptoms of attention, control, and memory problems. The analysis of the self-concept scale suggests that children with NE lack self-confidence. SN - 0028-3886 UR - https://www.unboundmedicine.com/medline/citation/30233003/Degree_centrality_and_voxel_mirrored_homotopic_connectivity_in_children_with_nocturnal_enuresis:_A_functional_MRI_study_ L2 - http://www.neurologyindia.com/article.asp?issn=0028-3886;year=2018;volume=66;issue=5;spage=1359;epage=1364;aulast=Jiang DB - PRIME DP - Unbound Medicine ER -