Tags

Type your tag names separated by a space and hit enter

Emergence of Monkeypox as the Most Important Orthopoxvirus Infection in Humans.
Front Public Health. 2018; 6:241.FP

Abstract

Monkeypox is an emerging zoonotic disease recognized as the most important orthopoxvirus infection in humans in the smallpox post-eradication era. The clinical presentation of monkeypox is similar to the one of smallpox. The case fatality rate of monkeypox (10%) lies between the case fatality rate of variola major (30%) and variola minor (1%). The disease is endemic in the Democratic Republic of the Congo, but other countries of Central and West Africa either reported cases of monkeypox in humans or circulation in wildlife. The disease was also imported once into the USA. The disease has always been considered rare and self-limiting, however recent sporadic reports suggest otherwise. Unfortunately, the collected data is limited, dispersed and often incomplete. Therefore, the objective of this review is to trace all reported human monkeypox outbreaks and relevant epidemiological information. The frequency and geographical spread of human monkeypox cases have increased in recent years, and there are huge gaps in our understanding of the disease's emergence, epidemiology, and ecology. The monkeypox virus is considered a high threat pathogen causing a disease of public health importance. Therefore, there is an urgent need to focus on building surveillance capacities which will provide valuable information for designing appropriate prevention, preparedness and response activities.

Authors+Show Affiliations

Laboratory of Clinical Virology, Department of Microbiology & Immunology, Rega Institute for Medical Research, KU Leuven, Leuven, Belgium.Laboratory of Clinical Virology, Department of Microbiology & Immunology, Rega Institute for Medical Research, KU Leuven, Leuven, Belgium.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

30234087

Citation

Sklenovská, Nikola, and Marc Van Ranst. "Emergence of Monkeypox as the Most Important Orthopoxvirus Infection in Humans." Frontiers in Public Health, vol. 6, 2018, p. 241.
Sklenovská N, Van Ranst M. Emergence of Monkeypox as the Most Important Orthopoxvirus Infection in Humans. Frontiers in public health. 2018;6:241.
Sklenovská, N., & Van Ranst, M. (2018). Emergence of Monkeypox as the Most Important Orthopoxvirus Infection in Humans. Frontiers in Public Health, 6, 241. https://doi.org/10.3389/fpubh.2018.00241
Sklenovská N, Van Ranst M. Emergence of Monkeypox as the Most Important Orthopoxvirus Infection in Humans. Frontiers in public health. 2018;6:241. PubMed PMID: 30234087.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Emergence of Monkeypox as the Most Important Orthopoxvirus Infection in Humans. AU - Sklenovská,Nikola, AU - Van Ranst,Marc, Y1 - 2018/09/04/ PY - 2018/04/10/received PY - 2018/08/10/accepted PY - 2018/9/21/entrez PY - 2018/9/21/pubmed PY - 2018/9/21/medline KW - disease outbreaks KW - emerging infectious diseases KW - monkeypox KW - one health KW - orthopoxvirus KW - zoonosis SP - 241 EP - 241 JF - Frontiers in public health VL - 6 N2 - Monkeypox is an emerging zoonotic disease recognized as the most important orthopoxvirus infection in humans in the smallpox post-eradication era. The clinical presentation of monkeypox is similar to the one of smallpox. The case fatality rate of monkeypox (10%) lies between the case fatality rate of variola major (30%) and variola minor (1%). The disease is endemic in the Democratic Republic of the Congo, but other countries of Central and West Africa either reported cases of monkeypox in humans or circulation in wildlife. The disease was also imported once into the USA. The disease has always been considered rare and self-limiting, however recent sporadic reports suggest otherwise. Unfortunately, the collected data is limited, dispersed and often incomplete. Therefore, the objective of this review is to trace all reported human monkeypox outbreaks and relevant epidemiological information. The frequency and geographical spread of human monkeypox cases have increased in recent years, and there are huge gaps in our understanding of the disease's emergence, epidemiology, and ecology. The monkeypox virus is considered a high threat pathogen causing a disease of public health importance. Therefore, there is an urgent need to focus on building surveillance capacities which will provide valuable information for designing appropriate prevention, preparedness and response activities. SN - 2296-2565 UR - https://www.unboundmedicine.com/medline/citation/30234087/Emergence_of_Monkeypox_as_the_Most_Important_Orthopoxvirus_Infection_in_Humans_ L2 - https://doi.org/10.3389/fpubh.2018.00241 DB - PRIME DP - Unbound Medicine ER -
Try the Free App:
Prime PubMed app for iOS iPhone iPad
Prime PubMed app for Android
Prime PubMed is provided
free to individuals by:
Unbound Medicine.