Tags

Type your tag names separated by a space and hit enter

Therapeutic effect of the antiviral agent ribavirin in Junín virus infection of primates.
J Med Virol. 1986 Nov; 20(3):261-7.JM

Abstract

In order to assess the effect of the antiviral Ribavirin on the course of Junín virus infection in Callithrix jacchus, seven inoculated monkeys were treated with 15 mg of the drug, twice a day, starting 6 days after infection when all animals were viremic. The three untreated controls showed typical signs of Junín virus infection at 14 days pi and their mean time of death was 18 days. In contrast, no signs of illness were detected in Ribavirin-treated animals until 24 days pi, when marmosets showed signs of neurological involvement: 5 of these animals died (mean day of death: 36) but the two remaining treated monkeys improved and survived infection without sequelae. The comparison of survival rates (0% vs 28%) and the delay of the mean day of death observed indicates that the Ribavirin treatment used has therapeutic effect on Junín virus infection in vivo.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

3023541

Citation

Weissenbacher, M C., et al. "Therapeutic Effect of the Antiviral Agent Ribavirin in Junín Virus Infection of Primates." Journal of Medical Virology, vol. 20, no. 3, 1986, pp. 261-7.
Weissenbacher MC, Calello MA, Merani MS, et al. Therapeutic effect of the antiviral agent ribavirin in Junín virus infection of primates. J Med Virol. 1986;20(3):261-7.
Weissenbacher, M. C., Calello, M. A., Merani, M. S., McCormick, J. B., & Rodriguez, M. (1986). Therapeutic effect of the antiviral agent ribavirin in Junín virus infection of primates. Journal of Medical Virology, 20(3), 261-7.
Weissenbacher MC, et al. Therapeutic Effect of the Antiviral Agent Ribavirin in Junín Virus Infection of Primates. J Med Virol. 1986;20(3):261-7. PubMed PMID: 3023541.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Therapeutic effect of the antiviral agent ribavirin in Junín virus infection of primates. AU - Weissenbacher,M C, AU - Calello,M A, AU - Merani,M S, AU - McCormick,J B, AU - Rodriguez,M, PY - 1986/11/1/pubmed PY - 1986/11/1/medline PY - 1986/11/1/entrez SP - 261 EP - 7 JF - Journal of medical virology JO - J Med Virol VL - 20 IS - 3 N2 - In order to assess the effect of the antiviral Ribavirin on the course of Junín virus infection in Callithrix jacchus, seven inoculated monkeys were treated with 15 mg of the drug, twice a day, starting 6 days after infection when all animals were viremic. The three untreated controls showed typical signs of Junín virus infection at 14 days pi and their mean time of death was 18 days. In contrast, no signs of illness were detected in Ribavirin-treated animals until 24 days pi, when marmosets showed signs of neurological involvement: 5 of these animals died (mean day of death: 36) but the two remaining treated monkeys improved and survived infection without sequelae. The comparison of survival rates (0% vs 28%) and the delay of the mean day of death observed indicates that the Ribavirin treatment used has therapeutic effect on Junín virus infection in vivo. SN - 0146-6615 UR - https://www.unboundmedicine.com/medline/citation/3023541/Therapeutic_effect_of_the_antiviral_agent_ribavirin_in_Junín_virus_infection_of_primates_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0146-6615&date=1986&volume=20&issue=3&spage=261 DB - PRIME DP - Unbound Medicine ER -