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Long-term follow-up of pachychoroid pigment epitheliopathy and lesion characteristics.
Graefes Arch Clin Exp Ophthalmol. 2018 Dec; 256(12):2319-2326.GA

Abstract

AIMS

To investigate conversion of pachychoroid pigment epitheliopathy (PPE) lesions and the development of other pachychoroid spectrum diseases in patients with PPE during follow-up.

METHODS

We retrospectively reviewed medical records of 46 eyes of 44 patients who had a diagnosis of PPE and were followed up for at least 3 years.

RESULTS

Eyes with PPE (17.4%) developed central serous chorioretinopathy (CSC), and none developed pachychoroid neovasculopathy or polypoidal choroidal vasculopathy. Of 74 initial PPE lesions, 21.6% were retinal pigment epithelium (RPE) thickening, 36.5% were pigment epithelium detachment (PED), and 41.9% were RPE elevation with microbreak appearance (REwM). Five (62.5%) of the eight initial PPE lesions progressing to CSC were REwM. Two developed directly from the REwM and three REwMs transformed to PED first, and then progressed to CSC. Three initial PEDs progressed to CSC. REwMs can also transform to PED and RPE thickening. No initial PEDs or RPE thickenings transformed to a REwM. Of the new PPE lesions, 60% were REwM, 26.7% were PEDs, and 13.3% were RPE thickening.

CONCLUSION

The smallest PPE lesion that can be detected is a REwM of RPE. It may be the precursor lesion for pachychoroid spectrum disease, but further large-scale prospective studies are required.

Authors+Show Affiliations

Istanbul Retina Institute, Hakkı Yeten Cad. Unimed Center No: 19/7 Fulya - Şişli, 34349, Istanbul, Turkey. mkaracorlu@gmail.com.Istanbul Retina Institute, Hakkı Yeten Cad. Unimed Center No: 19/7 Fulya - Şişli, 34349, Istanbul, Turkey.Istanbul Retina Institute, Hakkı Yeten Cad. Unimed Center No: 19/7 Fulya - Şişli, 34349, Istanbul, Turkey.Istanbul Retina Institute, Hakkı Yeten Cad. Unimed Center No: 19/7 Fulya - Şişli, 34349, Istanbul, Turkey.Istanbul Retina Institute, Hakkı Yeten Cad. Unimed Center No: 19/7 Fulya - Şişli, 34349, Istanbul, Turkey.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

30238190

Citation

Karacorlu, Murat, et al. "Long-term Follow-up of Pachychoroid Pigment Epitheliopathy and Lesion Characteristics." Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Fur Klinische Und Experimentelle Ophthalmologie, vol. 256, no. 12, 2018, pp. 2319-2326.
Karacorlu M, Ersoz MG, Arf S, et al. Long-term follow-up of pachychoroid pigment epitheliopathy and lesion characteristics. Graefes Arch Clin Exp Ophthalmol. 2018;256(12):2319-2326.
Karacorlu, M., Ersoz, M. G., Arf, S., Hocaoglu, M., & Sayman Muslubas, I. (2018). Long-term follow-up of pachychoroid pigment epitheliopathy and lesion characteristics. Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Fur Klinische Und Experimentelle Ophthalmologie, 256(12), 2319-2326. https://doi.org/10.1007/s00417-018-4144-0
Karacorlu M, et al. Long-term Follow-up of Pachychoroid Pigment Epitheliopathy and Lesion Characteristics. Graefes Arch Clin Exp Ophthalmol. 2018;256(12):2319-2326. PubMed PMID: 30238190.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Long-term follow-up of pachychoroid pigment epitheliopathy and lesion characteristics. AU - Karacorlu,Murat, AU - Ersoz,M Giray, AU - Arf,Serra, AU - Hocaoglu,Mumin, AU - Sayman Muslubas,Isil, Y1 - 2018/09/21/ PY - 2018/05/30/received PY - 2018/09/14/accepted PY - 2018/09/08/revised PY - 2018/9/22/pubmed PY - 2018/11/20/medline PY - 2018/9/22/entrez KW - Central serous chorioretinopathy KW - Choroidal hyperpermeability KW - Microbreak KW - Pachychoroid neovasculopathy KW - Pachychoroid pigment epitheliopathy KW - Polypoidal choroidal vasculopathy SP - 2319 EP - 2326 JF - Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie JO - Graefes Arch. Clin. Exp. Ophthalmol. VL - 256 IS - 12 N2 - AIMS: To investigate conversion of pachychoroid pigment epitheliopathy (PPE) lesions and the development of other pachychoroid spectrum diseases in patients with PPE during follow-up. METHODS: We retrospectively reviewed medical records of 46 eyes of 44 patients who had a diagnosis of PPE and were followed up for at least 3 years. RESULTS: Eyes with PPE (17.4%) developed central serous chorioretinopathy (CSC), and none developed pachychoroid neovasculopathy or polypoidal choroidal vasculopathy. Of 74 initial PPE lesions, 21.6% were retinal pigment epithelium (RPE) thickening, 36.5% were pigment epithelium detachment (PED), and 41.9% were RPE elevation with microbreak appearance (REwM). Five (62.5%) of the eight initial PPE lesions progressing to CSC were REwM. Two developed directly from the REwM and three REwMs transformed to PED first, and then progressed to CSC. Three initial PEDs progressed to CSC. REwMs can also transform to PED and RPE thickening. No initial PEDs or RPE thickenings transformed to a REwM. Of the new PPE lesions, 60% were REwM, 26.7% were PEDs, and 13.3% were RPE thickening. CONCLUSION: The smallest PPE lesion that can be detected is a REwM of RPE. It may be the precursor lesion for pachychoroid spectrum disease, but further large-scale prospective studies are required. SN - 1435-702X UR - https://www.unboundmedicine.com/medline/citation/30238190/Long_term_follow_up_of_pachychoroid_pigment_epitheliopathy_and_lesion_characteristics_ L2 - https://dx.doi.org/10.1007/s00417-018-4144-0 DB - PRIME DP - Unbound Medicine ER -