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Defining sarcopenia in terms of skeletal health.
Arch Osteoporos. 2018 09 20; 13(1):100.AO

Abstract

Among several sarcopenic indices, height-adjusted appendicular lean mass (ALM) in men and BMI-adjusted ALM in women are associated with fragility fracture. Handgrip strength is the risk factor for fragility fracture.

PURPOSE

Various sarcopenia definitions and cutoff points result in mixed skeletal health results. Here, we aimed to determine a suitable definition and elucidate the cutoff values of sarcopenic indices for identifying fracture risk in a community-dwelling Korean cohort.

METHODS

In an Ansung cohort study (2009-2010), we included 1201 men aged > 50 years and 1627 postmenopausal women with a median age of 64 years. Body composition and bone mineral density were derived on dual-energy X-ray absorptiometry. Grip strength was measured using a hand dynamometer. Fragility fractures included the history of osteoporotic fractures using self-reported questionnaires.

RESULTS

Among appendicular lean mass (ALM)/body mass index (BMI), ALM/height2, and ALM/weight, ALM/height2 for men and ALM/BMI for women significantly predicted fragility fractures. On receiver operating characteristic curve analysis, the cutoff values of ALM/height2 in men and ALM/BMI in women were 7.69 kg/m2, and 0.57, respectively. The optimal grip strength values were 31 kg in men and 19 kg in women. The odds ratios of low ALM/height2 (95% confidence interval) and weak grip strength for fragility fracture were 1.95 (1.03-3.68) and 2.05 (1.01-4.18), respectively, in men after covariate adjustment. The combination of low ALM/height2 and weak grip strength increased fragility fractures 2.16-fold in men. Only the combination of low ALM/BMI and grip strength increased the fracture risk by 1.76-fold in women.

CONCLUSIONS

In men, low ALM/height2 or grip strength played a role in fragility fractures. In women, only the combination of low ALM/BMI and grip strength had discriminatory power for fragility fractures.

Authors+Show Affiliations

Department of Internal Medicine, Seoul National University College of Medicine, 101 Daehak-ro, Jongno-gu, Seoul, 110-744, Republic of Korea.Department of Internal Medicine, Seoul National University College of Medicine, 101 Daehak-ro, Jongno-gu, Seoul, 110-744, Republic of Korea.Department of Anatomy, Seoul National University College of Medicine, Seoul, Republic of Korea.Department of Internal Medicine, Chungbuk National University Hospital, Cheongju Si, Republic of Korea.Department of Internal Medicine, VHS Medical center, Seoul, Republic of Korea.Department of Preventive Medicine, Ajou University School of Medicine, #5 Wonchon-Dong, Youngtong-Gu, Suwon, 443-721, Republic of Korea.Department of Internal Medicine, Seoul National University College of Medicine, 101 Daehak-ro, Jongno-gu, Seoul, 110-744, Republic of Korea. csshin@snu.ac.kr.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

30238222

Citation

Kim, Jung Hee, et al. "Defining Sarcopenia in Terms of Skeletal Health." Archives of Osteoporosis, vol. 13, no. 1, 2018, p. 100.
Kim JH, Hong AR, Choi HJ, et al. Defining sarcopenia in terms of skeletal health. Arch Osteoporos. 2018;13(1):100.
Kim, J. H., Hong, A. R., Choi, H. J., Ku, E. J., Lee, J. H., Cho, N. H., & Shin, C. S. (2018). Defining sarcopenia in terms of skeletal health. Archives of Osteoporosis, 13(1), 100. https://doi.org/10.1007/s11657-018-0511-z
Kim JH, et al. Defining Sarcopenia in Terms of Skeletal Health. Arch Osteoporos. 2018 09 20;13(1):100. PubMed PMID: 30238222.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Defining sarcopenia in terms of skeletal health. AU - Kim,Jung Hee, AU - Hong,A Ram, AU - Choi,Hyung Jin, AU - Ku,Eu Jeong, AU - Lee,Ji Hyun, AU - Cho,Nam H, AU - Shin,Chan Soo, Y1 - 2018/09/20/ PY - 2018/06/19/received PY - 2018/08/26/accepted PY - 2018/9/22/entrez PY - 2018/9/22/pubmed PY - 2019/9/4/medline KW - Bone KW - Fracture KW - Muscle mass KW - Muscle strength SP - 100 EP - 100 JF - Archives of osteoporosis JO - Arch Osteoporos VL - 13 IS - 1 N2 - : Among several sarcopenic indices, height-adjusted appendicular lean mass (ALM) in men and BMI-adjusted ALM in women are associated with fragility fracture. Handgrip strength is the risk factor for fragility fracture. PURPOSE: Various sarcopenia definitions and cutoff points result in mixed skeletal health results. Here, we aimed to determine a suitable definition and elucidate the cutoff values of sarcopenic indices for identifying fracture risk in a community-dwelling Korean cohort. METHODS: In an Ansung cohort study (2009-2010), we included 1201 men aged > 50 years and 1627 postmenopausal women with a median age of 64 years. Body composition and bone mineral density were derived on dual-energy X-ray absorptiometry. Grip strength was measured using a hand dynamometer. Fragility fractures included the history of osteoporotic fractures using self-reported questionnaires. RESULTS: Among appendicular lean mass (ALM)/body mass index (BMI), ALM/height2, and ALM/weight, ALM/height2 for men and ALM/BMI for women significantly predicted fragility fractures. On receiver operating characteristic curve analysis, the cutoff values of ALM/height2 in men and ALM/BMI in women were 7.69 kg/m2, and 0.57, respectively. The optimal grip strength values were 31 kg in men and 19 kg in women. The odds ratios of low ALM/height2 (95% confidence interval) and weak grip strength for fragility fracture were 1.95 (1.03-3.68) and 2.05 (1.01-4.18), respectively, in men after covariate adjustment. The combination of low ALM/height2 and weak grip strength increased fragility fractures 2.16-fold in men. Only the combination of low ALM/BMI and grip strength increased the fracture risk by 1.76-fold in women. CONCLUSIONS: In men, low ALM/height2 or grip strength played a role in fragility fractures. In women, only the combination of low ALM/BMI and grip strength had discriminatory power for fragility fractures. SN - 1862-3514 UR - https://www.unboundmedicine.com/medline/citation/30238222/Defining_sarcopenia_in_terms_of_skeletal_health_ L2 - https://dx.doi.org/10.1007/s11657-018-0511-z DB - PRIME DP - Unbound Medicine ER -