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Comparison of the mitral valve morphologies of Cavalier King Charles Spaniels and dogs of other breeds using 3D transthoracic echocardiography.
J Vet Intern Med. 2018 Sep; 32(5):1564-1569.JV

Abstract

BACKGROUND

Myxomatous mitral valve disease (MMVD) is more prevalent in Cavalier King Charles Spaniels (CKCSs) compared to dogs of other breeds at a given age. Abnormal valvular stress is thought to contribute to the development and progression of MMVD, and a relationship exists between mitral valve (MV) morphology and stress acting on the valve.

OBJECTIVES

To determine whether the MV morphology of healthy adult CKCSs differs from the morphology of healthy adult dogs of other breeds determined by RT-3DTTE.

ANIMALS

Thirty-five healthy CKCSs and 41 healthy dogs of other breeds.

METHODS

Prospective cross-sectional study. Dogs underwent physical examination, conventional echocardiography, and RT-3DTTE. RT-3DTTE datasets were analyzed using dedicated software for MV morphologic analysis. Morphologic variables were compared between CKCSs and dogs of other breeds.

RESULTS

The MV of healthy CKCSs had a smaller annulus height (0.46 ± 0.11 vs. 0.56 ± 0.17; P = .0021), tenting height (0.26 ± 0.12 vs. 0.42 ± 0.18; P < .001), tenting area (0.42 ± 0.15 vs. 0.79 ± 0.34; P < .001), normalized tenting volume (0.09 [0.05-0.13] vs. 0.14 [0.10-0.20]; P < .001), and normalized area of the posterior leaflet (0.57 ± 0.15 vs. 0.66 ± 0.18; P = .016) compared to healthy dogs of other breeds; this results in CKCSs having a flatter MV with reduced tenting, compared to the MV of other breeds.

CONCLUSIONS AND CLINICAL IMPORTANCE

These morphologic features could confer a mechanical disadvantage and play a role in the predisposition of CKCSs to the early development of MMVD.

Authors+Show Affiliations

Department of Small Animal Clinical Sciences, Virginia-Maryland College of Veterinary Medicine, Blacksburg, Virginia.Department of Small Animal Clinical Sciences, Virginia-Maryland College of Veterinary Medicine, Blacksburg, Virginia.Department of Small Animal Clinical Sciences, Virginia-Maryland College of Veterinary Medicine, Blacksburg, Virginia.Department of Small Animal Clinical Sciences, Virginia-Maryland College of Veterinary Medicine, Blacksburg, Virginia.Department of Clinical Sciences, Swedish University of Agricultural Science, Uppsala, Sweden.Department of Clinical Sciences, Swedish University of Agricultural Science, Uppsala, Sweden.Department of Small Animal Clinical Sciences, Virginia-Maryland College of Veterinary Medicine, Blacksburg, Virginia.Department of Small Animal Clinical Sciences, Virginia-Maryland College of Veterinary Medicine, Blacksburg, Virginia.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

30238697

Citation

Menciotti, Giulio, et al. "Comparison of the Mitral Valve Morphologies of Cavalier King Charles Spaniels and Dogs of Other Breeds Using 3D Transthoracic Echocardiography." Journal of Veterinary Internal Medicine, vol. 32, no. 5, 2018, pp. 1564-1569.
Menciotti G, Borgarelli M, Aherne M, et al. Comparison of the mitral valve morphologies of Cavalier King Charles Spaniels and dogs of other breeds using 3D transthoracic echocardiography. J Vet Intern Med. 2018;32(5):1564-1569.
Menciotti, G., Borgarelli, M., Aherne, M., Camacho, P., Häggström, J., Ljungvall, I., Lahmers, S. M., & Abbott, J. A. (2018). Comparison of the mitral valve morphologies of Cavalier King Charles Spaniels and dogs of other breeds using 3D transthoracic echocardiography. Journal of Veterinary Internal Medicine, 32(5), 1564-1569. https://doi.org/10.1111/jvim.15252
Menciotti G, et al. Comparison of the Mitral Valve Morphologies of Cavalier King Charles Spaniels and Dogs of Other Breeds Using 3D Transthoracic Echocardiography. J Vet Intern Med. 2018;32(5):1564-1569. PubMed PMID: 30238697.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Comparison of the mitral valve morphologies of Cavalier King Charles Spaniels and dogs of other breeds using 3D transthoracic echocardiography. AU - Menciotti,Giulio, AU - Borgarelli,Michele, AU - Aherne,Michael, AU - Camacho,Paula, AU - Häggström,Jens, AU - Ljungvall,Ingrid, AU - Lahmers,Sunshine M, AU - Abbott,Jonathan A, Y1 - 2018/09/20/ PY - 2018/02/20/received PY - 2018/04/25/revised PY - 2018/05/31/accepted PY - 2018/9/22/pubmed PY - 2019/1/12/medline PY - 2018/9/22/entrez KW - canine KW - heart KW - imaging KW - myxomatous SP - 1564 EP - 1569 JF - Journal of veterinary internal medicine JO - J. Vet. Intern. Med. VL - 32 IS - 5 N2 - BACKGROUND: Myxomatous mitral valve disease (MMVD) is more prevalent in Cavalier King Charles Spaniels (CKCSs) compared to dogs of other breeds at a given age. Abnormal valvular stress is thought to contribute to the development and progression of MMVD, and a relationship exists between mitral valve (MV) morphology and stress acting on the valve. OBJECTIVES: To determine whether the MV morphology of healthy adult CKCSs differs from the morphology of healthy adult dogs of other breeds determined by RT-3DTTE. ANIMALS: Thirty-five healthy CKCSs and 41 healthy dogs of other breeds. METHODS: Prospective cross-sectional study. Dogs underwent physical examination, conventional echocardiography, and RT-3DTTE. RT-3DTTE datasets were analyzed using dedicated software for MV morphologic analysis. Morphologic variables were compared between CKCSs and dogs of other breeds. RESULTS: The MV of healthy CKCSs had a smaller annulus height (0.46 ± 0.11 vs. 0.56 ± 0.17; P = .0021), tenting height (0.26 ± 0.12 vs. 0.42 ± 0.18; P < .001), tenting area (0.42 ± 0.15 vs. 0.79 ± 0.34; P < .001), normalized tenting volume (0.09 [0.05-0.13] vs. 0.14 [0.10-0.20]; P < .001), and normalized area of the posterior leaflet (0.57 ± 0.15 vs. 0.66 ± 0.18; P = .016) compared to healthy dogs of other breeds; this results in CKCSs having a flatter MV with reduced tenting, compared to the MV of other breeds. CONCLUSIONS AND CLINICAL IMPORTANCE: These morphologic features could confer a mechanical disadvantage and play a role in the predisposition of CKCSs to the early development of MMVD. SN - 1939-1676 UR - https://www.unboundmedicine.com/medline/citation/30238697/Comparison_of_the_mitral_valve_morphologies_of_Cavalier_King_Charles_Spaniels_and_dogs_of_other_breeds_using_3D_transthoracic_echocardiography_ L2 - https://doi.org/10.1111/jvim.15252 DB - PRIME DP - Unbound Medicine ER -