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Blueberry extract promotes longevity and stress tolerance via DAF-16 in Caenorhabditis elegans.
Food Funct 2018; 9(10):5273-5282FF

Abstract

Blueberry is rich in bioactive phytochemicals with a wide of range of biological activities and health benefits. However, little is known about their effects on aging. The objectives of this study were to evaluate the effects of supplementation with a blueberry extract (BE) on lifespan and stress resistance using Caenorhabditis elegans (C. elegans) as a model. The mechanisms of these effects were explored using RNAi technology. The mean lifespan of C. elegans treated with BE at 50, 100, and 200 mg mL-1 was significantly increased by 22.2%, 36.5%, and 44.4%, respectively, in a dose-dependent manner. In addition, supplementation with BE improved motility and decreased lipofuscin accumulation. C. elegans pretreated with BE were more resistant than untreated C. elegans to stresses (heat, ultraviolet-B radiation, and paraquat). Treatment with BE resulted in up-regulation of genes related to antioxidant systems, including sod-3, cat-1, mev-1, skn-1, mek-1, nhr-8, and daf-16. Suppression of daf-16 by RNAi shortened the lifespan of C. elegans and inhibited the expression of sod-3, suggesting that BE may regulate sod-3 downstream of daf-16 to extend lifespan and stress resistance. Our findings revealed that, in C. elegans, BE can prolong the lifespan, improve health indexes, and enhance stress resistance.

Authors+Show Affiliations

School of Food Science and Engineering, South China University of Technology, Guangzhou 510641, China.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

30238944

Citation

Wang, Huailing, et al. "Blueberry Extract Promotes Longevity and Stress Tolerance Via DAF-16 in Caenorhabditis Elegans." Food & Function, vol. 9, no. 10, 2018, pp. 5273-5282.
Wang H, Liu J, Li T, et al. Blueberry extract promotes longevity and stress tolerance via DAF-16 in Caenorhabditis elegans. Food Funct. 2018;9(10):5273-5282.
Wang, H., Liu, J., Li, T., & Liu, R. H. (2018). Blueberry extract promotes longevity and stress tolerance via DAF-16 in Caenorhabditis elegans. Food & Function, 9(10), pp. 5273-5282. doi:10.1039/c8fo01680a.
Wang H, et al. Blueberry Extract Promotes Longevity and Stress Tolerance Via DAF-16 in Caenorhabditis Elegans. Food Funct. 2018 Oct 17;9(10):5273-5282. PubMed PMID: 30238944.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Blueberry extract promotes longevity and stress tolerance via DAF-16 in Caenorhabditis elegans. AU - Wang,Huailing, AU - Liu,Jie, AU - Li,Tong, AU - Liu,Rui Hai, PY - 2018/9/22/pubmed PY - 2019/1/24/medline PY - 2018/9/22/entrez SP - 5273 EP - 5282 JF - Food & function JO - Food Funct VL - 9 IS - 10 N2 - Blueberry is rich in bioactive phytochemicals with a wide of range of biological activities and health benefits. However, little is known about their effects on aging. The objectives of this study were to evaluate the effects of supplementation with a blueberry extract (BE) on lifespan and stress resistance using Caenorhabditis elegans (C. elegans) as a model. The mechanisms of these effects were explored using RNAi technology. The mean lifespan of C. elegans treated with BE at 50, 100, and 200 mg mL-1 was significantly increased by 22.2%, 36.5%, and 44.4%, respectively, in a dose-dependent manner. In addition, supplementation with BE improved motility and decreased lipofuscin accumulation. C. elegans pretreated with BE were more resistant than untreated C. elegans to stresses (heat, ultraviolet-B radiation, and paraquat). Treatment with BE resulted in up-regulation of genes related to antioxidant systems, including sod-3, cat-1, mev-1, skn-1, mek-1, nhr-8, and daf-16. Suppression of daf-16 by RNAi shortened the lifespan of C. elegans and inhibited the expression of sod-3, suggesting that BE may regulate sod-3 downstream of daf-16 to extend lifespan and stress resistance. Our findings revealed that, in C. elegans, BE can prolong the lifespan, improve health indexes, and enhance stress resistance. SN - 2042-650X UR - https://www.unboundmedicine.com/medline/citation/30238944/Blueberry_extract_promotes_longevity_and_stress_tolerance_via_DAF_16_in_Caenorhabditis_elegans_ L2 - https://doi.org/10.1039/c8fo01680a DB - PRIME DP - Unbound Medicine ER -