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Health outcomes associated with use of hormonal contraception: breast cancer.
Curr Opin Obstet Gynecol. 2018 12; 30(6):414-418.CO

Abstract

PURPOSE OF REVIEW

To review recent literature on health outcomes associated with use of hormonal contraception with a focus on breast cancer.

RECENT FINDINGS

A large cohort study documented an increased risk of breast cancer among hormonal contraceptive users compared to those who had never used hormonal contraception. The overall relative risk of breast cancer among current or recent users was 1.2 [95% confidence interval (CI), 1.14-1.26]. Overall, this translates into one additional case of breast cancer for every 7690 users of hormonal contraception. Recent publications have also documented a decrease in risk for endometrial, ovarian, and colorectal cancers among hormonal contraceptive users. Based on these data, it is estimated that a third of endometrial and ovarian cancers and a fifth of colorectal cancers were prevented with combined oral contraceptive use.

SUMMARY

Several factors must be taken into consideration regarding the risk of breast cancer associated with hormonal contraceptive use. Contraceptive benefits related to preventing unintended pregnancy are protective against associated maternal morbidity and mortality. Noncontraceptive benefits of protecting against other types of cancers must also be considered. Overall, breast cancer risk is low among hormonal contraceptive users and women should be counseled accordingly.

Authors+Show Affiliations

Division of Family Planning Services and Research, Department of Obstetrics and Gynecology, School of Medicine, Stanford University, Stanford, California, USA.No affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

30239373

Citation

Schneyer, Rebecca, and Klaira Lerma. "Health Outcomes Associated With Use of Hormonal Contraception: Breast Cancer." Current Opinion in Obstetrics & Gynecology, vol. 30, no. 6, 2018, pp. 414-418.
Schneyer R, Lerma K. Health outcomes associated with use of hormonal contraception: breast cancer. Curr Opin Obstet Gynecol. 2018;30(6):414-418.
Schneyer, R., & Lerma, K. (2018). Health outcomes associated with use of hormonal contraception: breast cancer. Current Opinion in Obstetrics & Gynecology, 30(6), 414-418. https://doi.org/10.1097/GCO.0000000000000493
Schneyer R, Lerma K. Health Outcomes Associated With Use of Hormonal Contraception: Breast Cancer. Curr Opin Obstet Gynecol. 2018;30(6):414-418. PubMed PMID: 30239373.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Health outcomes associated with use of hormonal contraception: breast cancer. AU - Schneyer,Rebecca, AU - Lerma,Klaira, PY - 2018/9/22/pubmed PY - 2019/7/31/medline PY - 2018/9/22/entrez SP - 414 EP - 418 JF - Current opinion in obstetrics & gynecology JO - Curr. Opin. Obstet. Gynecol. VL - 30 IS - 6 N2 - PURPOSE OF REVIEW: To review recent literature on health outcomes associated with use of hormonal contraception with a focus on breast cancer. RECENT FINDINGS: A large cohort study documented an increased risk of breast cancer among hormonal contraceptive users compared to those who had never used hormonal contraception. The overall relative risk of breast cancer among current or recent users was 1.2 [95% confidence interval (CI), 1.14-1.26]. Overall, this translates into one additional case of breast cancer for every 7690 users of hormonal contraception. Recent publications have also documented a decrease in risk for endometrial, ovarian, and colorectal cancers among hormonal contraceptive users. Based on these data, it is estimated that a third of endometrial and ovarian cancers and a fifth of colorectal cancers were prevented with combined oral contraceptive use. SUMMARY: Several factors must be taken into consideration regarding the risk of breast cancer associated with hormonal contraceptive use. Contraceptive benefits related to preventing unintended pregnancy are protective against associated maternal morbidity and mortality. Noncontraceptive benefits of protecting against other types of cancers must also be considered. Overall, breast cancer risk is low among hormonal contraceptive users and women should be counseled accordingly. SN - 1473-656X UR - https://www.unboundmedicine.com/medline/citation/30239373/Health_outcomes_associated_with_use_of_hormonal_contraception:_breast_cancer_ L2 - http://dx.doi.org/10.1097/GCO.0000000000000493 DB - PRIME DP - Unbound Medicine ER -