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Maternal Smoking During Pregnancy and Timing of Puberty in Sons and Daughters: A Population-Based Cohort Study.
Am J Epidemiol. 2019 01 01; 188(1):47-56.AJ

Abstract

Because early puberty has been linked to diseases later in life, identification of modifiable causes of early puberty is of interest. We explored the possible associations between maternal smoking during pregnancy and pubertal development in sons and daughters. Between 2012 and 2017, 15,819 children from the Danish National Birth Cohort, born during 2000-2003, provided half-yearly information on puberty from the age of 11 years. We estimated adjusted age differences (in months) at attaining various pubertal milestones, including Tanner stages, per 10 daily cigarettes smoked in the first trimester of gestation. In sons, exposure to smoking in utero was associated with earlier genital development (Tanner 2, -1.3 months, 95% confidence interval (CI): -2.5, 0.0; Tanner 5, -3.7 months, 95% CI: -5.3, -2.0), pubic hair development (Tanner 2, -1.8 months, 95% CI: -2.9, -0.6; Tanner 5, -2.9 months, 95% CI: -4.2, -1.7), and voice break (-2.4 months, 95% CI: -3.6, -1.3). In daughters, maternal smoking was associated with earlier breast development (Tanner 2, -3.4 months, 95% CI: -5.3, -1.5; Tanner 5, -4.7 months, 95% CI: -6.5, -2.9), pubic hair development stages 3-5 (Tanner 5, -2.5 months, 95% CI: -4.1, -1.0), and menarche (-3.1 months, 95% CI: -4.0, -2.3). Fetal exposure to tobacco smoke might advance timing of puberty in boys and girls.

Authors+Show Affiliations

Department of Public Health, Section for Epidemiology, Aarhus University, Aarhus, Denmark.Department of Public Health, Section for Epidemiology, Aarhus University, Aarhus, Denmark.Department of Public Health, Section for Epidemiology, Aarhus University, Aarhus, Denmark.Department of Public Health, Section for Biostatistics, Aarhus University, Aarhus, Denmark.Department of Clinical Epidemiology, Aarhus University Hospital, Aarhus, Denmark. Department of Epidemiology, Fielding School of Public Health, University of California Los Angeles, Los Angeles, California.Department of Pediatrics, Perinatal Epidemiology Research Unit, Aarhus University Hospital, Aarhus, Denmark.Department of Public Health, Section for Epidemiology, Aarhus University, Aarhus, Denmark.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

30239589

Citation

Brix, Nis, et al. "Maternal Smoking During Pregnancy and Timing of Puberty in Sons and Daughters: a Population-Based Cohort Study." American Journal of Epidemiology, vol. 188, no. 1, 2019, pp. 47-56.
Brix N, Ernst A, Lauridsen LLB, et al. Maternal Smoking During Pregnancy and Timing of Puberty in Sons and Daughters: A Population-Based Cohort Study. Am J Epidemiol. 2019;188(1):47-56.
Brix, N., Ernst, A., Lauridsen, L. L. B., Parner, E. T., Olsen, J., Henriksen, T. B., & Ramlau-Hansen, C. H. (2019). Maternal Smoking During Pregnancy and Timing of Puberty in Sons and Daughters: A Population-Based Cohort Study. American Journal of Epidemiology, 188(1), 47-56. https://doi.org/10.1093/aje/kwy206
Brix N, et al. Maternal Smoking During Pregnancy and Timing of Puberty in Sons and Daughters: a Population-Based Cohort Study. Am J Epidemiol. 2019 01 1;188(1):47-56. PubMed PMID: 30239589.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Maternal Smoking During Pregnancy and Timing of Puberty in Sons and Daughters: A Population-Based Cohort Study. AU - Brix,Nis, AU - Ernst,Andreas, AU - Lauridsen,Lea L B, AU - Parner,Erik T, AU - Olsen,Jørn, AU - Henriksen,Tine B, AU - Ramlau-Hansen,Cecilia H, PY - 2018/05/04/received PY - 2018/09/05/accepted PY - 2018/9/22/pubmed PY - 2019/11/19/medline PY - 2018/9/22/entrez SP - 47 EP - 56 JF - American journal of epidemiology JO - Am J Epidemiol VL - 188 IS - 1 N2 - Because early puberty has been linked to diseases later in life, identification of modifiable causes of early puberty is of interest. We explored the possible associations between maternal smoking during pregnancy and pubertal development in sons and daughters. Between 2012 and 2017, 15,819 children from the Danish National Birth Cohort, born during 2000-2003, provided half-yearly information on puberty from the age of 11 years. We estimated adjusted age differences (in months) at attaining various pubertal milestones, including Tanner stages, per 10 daily cigarettes smoked in the first trimester of gestation. In sons, exposure to smoking in utero was associated with earlier genital development (Tanner 2, -1.3 months, 95% confidence interval (CI): -2.5, 0.0; Tanner 5, -3.7 months, 95% CI: -5.3, -2.0), pubic hair development (Tanner 2, -1.8 months, 95% CI: -2.9, -0.6; Tanner 5, -2.9 months, 95% CI: -4.2, -1.7), and voice break (-2.4 months, 95% CI: -3.6, -1.3). In daughters, maternal smoking was associated with earlier breast development (Tanner 2, -3.4 months, 95% CI: -5.3, -1.5; Tanner 5, -4.7 months, 95% CI: -6.5, -2.9), pubic hair development stages 3-5 (Tanner 5, -2.5 months, 95% CI: -4.1, -1.0), and menarche (-3.1 months, 95% CI: -4.0, -2.3). Fetal exposure to tobacco smoke might advance timing of puberty in boys and girls. SN - 1476-6256 UR - https://www.unboundmedicine.com/medline/citation/30239589/Maternal_Smoking_During_Pregnancy_and_Timing_of_Puberty_in_Sons_and_Daughters:_A_Population_Based_Cohort_Study_ L2 - https://academic.oup.com/aje/article-lookup/doi/10.1093/aje/kwy206 DB - PRIME DP - Unbound Medicine ER -