Tags

Type your tag names separated by a space and hit enter

Long-term consumption of fruits and vegetables and risk of chronic obstructive pulmonary disease: a prospective cohort study of women.
Int J Epidemiol. 2018 12 01; 47(6):1897-1909.IJ

Abstract

Background

Fruits and vegetables, due to high antioxidant capacity, may protect the lung from oxidative damage caused by tobacco smoke and potentially prevent chronic obstructive pulmonary disease (COPD). Only one study based on baseline diet has examined fruit and vegetable consumption in relation to risk of COPD, and no previous studies have examined long-term diet.

Methods

We investigated whether long-term fruit and vegetable consumption was associated with COPD incidence among 34 739 women (age 48-83 years) in the population-based prospective Swedish Mammography Cohort. Fruit and vegetable consumption was assessed twice (1987, 1997) with a self-administered questionnaire. Cases of COPD were identified by linkage to the Swedish health register. Cox proportional hazard regression models were used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs).

Results

During follow-up from 2002 to 2014, 1512 women were diagnosed with COPD. Long-term fruit was associated with lower risk of COPD; women in the highest vs lowest quintile of consumption (≥2.5 vs <0.8 servings/day) had a 37% lower risk of COPD (95% CI: 25-48%; P-trend < 0.0001). No association was observed with long-term vegetable intake. Current and ex-smokers with low long-term consumption of fruits (<1 serving/day) in comparison to never smokers with high consumption (≥3 servings/day) had a 38-fold (HR: 38.1; 95% CI: 20.2-71.7) and 13-fold (HR: 12.5, 95% CI: 6.5-24.1) higher risk of COPD, respectively. However, no significant interaction between smoking status and fruit intake in relation to COPD incidence was observed (P-interaction = 0.95).

Conclusions

In this prospective cohort of middle-age and older women, long-term consumption of fruits but not vegetables was inversely associated with COPD incidence.

Authors+Show Affiliations

Unit of Nutritional Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, SE 171-77 Stockholm, Sweden. Nutrition Research Laboratory, Department of Human Nutrition, Warsaw University of Life Sciences-SGGW, Warsaw, Poland.Program in Epidemiology, Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.Unit for Lung and Airway Research, Institute of Environmental Medicine, Karolinska Institutet, SE 171-77 Stockholm, Sweden. Lung Allergy Clinic, Karolinska University Hospital, Stockholm, Sweden.Unit of Nutritional Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, SE 171-77 Stockholm, Sweden. Department of Surgical Sciences, Uppsala University, Uppsala, Sweden.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

30239739

Citation

Kaluza, Joanna, et al. "Long-term Consumption of Fruits and Vegetables and Risk of Chronic Obstructive Pulmonary Disease: a Prospective Cohort Study of Women." International Journal of Epidemiology, vol. 47, no. 6, 2018, pp. 1897-1909.
Kaluza J, Harris HR, Linden A, et al. Long-term consumption of fruits and vegetables and risk of chronic obstructive pulmonary disease: a prospective cohort study of women. Int J Epidemiol. 2018;47(6):1897-1909.
Kaluza, J., Harris, H. R., Linden, A., & Wolk, A. (2018). Long-term consumption of fruits and vegetables and risk of chronic obstructive pulmonary disease: a prospective cohort study of women. International Journal of Epidemiology, 47(6), 1897-1909. https://doi.org/10.1093/ije/dyy178
Kaluza J, et al. Long-term Consumption of Fruits and Vegetables and Risk of Chronic Obstructive Pulmonary Disease: a Prospective Cohort Study of Women. Int J Epidemiol. 2018 12 1;47(6):1897-1909. PubMed PMID: 30239739.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Long-term consumption of fruits and vegetables and risk of chronic obstructive pulmonary disease: a prospective cohort study of women. AU - Kaluza,Joanna, AU - Harris,Holly R, AU - Linden,Anders, AU - Wolk,Alicja, PY - 2018/08/10/accepted PY - 2018/9/22/pubmed PY - 2019/6/14/medline PY - 2018/9/22/entrez SP - 1897 EP - 1909 JF - International journal of epidemiology JO - Int J Epidemiol VL - 47 IS - 6 N2 - Background: Fruits and vegetables, due to high antioxidant capacity, may protect the lung from oxidative damage caused by tobacco smoke and potentially prevent chronic obstructive pulmonary disease (COPD). Only one study based on baseline diet has examined fruit and vegetable consumption in relation to risk of COPD, and no previous studies have examined long-term diet. Methods: We investigated whether long-term fruit and vegetable consumption was associated with COPD incidence among 34 739 women (age 48-83 years) in the population-based prospective Swedish Mammography Cohort. Fruit and vegetable consumption was assessed twice (1987, 1997) with a self-administered questionnaire. Cases of COPD were identified by linkage to the Swedish health register. Cox proportional hazard regression models were used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs). Results: During follow-up from 2002 to 2014, 1512 women were diagnosed with COPD. Long-term fruit was associated with lower risk of COPD; women in the highest vs lowest quintile of consumption (≥2.5 vs <0.8 servings/day) had a 37% lower risk of COPD (95% CI: 25-48%; P-trend < 0.0001). No association was observed with long-term vegetable intake. Current and ex-smokers with low long-term consumption of fruits (<1 serving/day) in comparison to never smokers with high consumption (≥3 servings/day) had a 38-fold (HR: 38.1; 95% CI: 20.2-71.7) and 13-fold (HR: 12.5, 95% CI: 6.5-24.1) higher risk of COPD, respectively. However, no significant interaction between smoking status and fruit intake in relation to COPD incidence was observed (P-interaction = 0.95). Conclusions: In this prospective cohort of middle-age and older women, long-term consumption of fruits but not vegetables was inversely associated with COPD incidence. SN - 1464-3685 UR - https://www.unboundmedicine.com/medline/citation/30239739/Long_term_consumption_of_fruits_and_vegetables_and_risk_of_chronic_obstructive_pulmonary_disease:_a_prospective_cohort_study_of_women_ L2 - https://academic.oup.com/ije/article-lookup/doi/10.1093/ije/dyy178 DB - PRIME DP - Unbound Medicine ER -