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Osmolality of a fortified human preterm milk: The effect of fortifier dosage, gestational age, lactation stage, and hospital practices.
Arch Pediatr. 2018 Oct; 25(7):411-415.AP

Abstract

OBJECTIVE

The purpose of this study was to evaluate the dose-dependent effect of human milk fortifier (HMF) on the osmolality of various preterm human milks (PHMs) at different gestational and lactation stages, and with different storage and treatment conditions that are routinely used in neonatal intensive care units (NICUs).

STUDY DESIGN

Twenty-four mothers who had given birth to their baby before 28 or between 29 and 31 weeks of pregnancy participated in the study after 1-2 weeks or 3-4 weeks breastfeeding after delivery. The study was a prospective, multicenter, comparative, and noninterventional study. Osmolality of fresh or pasteurized human milk stored at 4°C was measured (cryoscopy) at baseline, and 24hours after adding Suppletine® Human Milk fortifier (SHMF) at 3%, 4%, 4.5%, and 5% (w/v).

RESULTS

PHM without supplementation had an osmolality (mean±SD) of 301±8 mOsm/kgH2O (n=40; 95% CI: [298; 303]). Adding 3-5% SHMF induced a linear increase of osmolality (P<0.001; r2=0.975). With 4% SHMF, the osmolality measure was 443±13mOsm/kg H2O (95% CI: [439-447]). Neither a 24-hour storage at 4°C nor pasteurization induced a modification of osmolality compared to the fresh samples.

CONCLUSION

Whatever the origin and quality of milk as well as hospital practices, adding up to 4% (w/v) SHMF to PHM increases its nutritional quality and osmolality without exceeding 450mOsm/kgH2O, which is generally recognized as safe.

Authors+Show Affiliations

Hôpital Sud, CHU de Rennes, 16, boulevard de Bulgarie, 35200 Rennes, France. Electronic address: anne.sauret@chu-rennes.fr.CH Yves-Le-Foll, 10, rue Marcel-Proust, 22000 Saint-Brieuc, France.CH Yves-Le-Foll, 10, rue Marcel-Proust, 22000 Saint-Brieuc, France.Lactalis Recherche et Développement, 8, Fromy, 35240 Retiers, France.Lactalis Nutrition Santé, Parc d'activités secteur Est, 35370 Torcé, France.Lactalis Nutrition Santé, Parc d'activités secteur Est, 35370 Torcé, France.Lactalis Recherche et Développement, 8, Fromy, 35240 Retiers, France.Hôpital Sud, CHU de Rennes, 16, boulevard de Bulgarie, 35200 Rennes, France.

Pub Type(s)

Comparative Study
Journal Article
Multicenter Study

Language

eng

PubMed ID

30241780

Citation

Sauret, A, et al. "Osmolality of a Fortified Human Preterm Milk: the Effect of Fortifier Dosage, Gestational Age, Lactation Stage, and Hospital Practices." Archives De Pediatrie : Organe Officiel De La Societe Francaise De Pediatrie, vol. 25, no. 7, 2018, pp. 411-415.
Sauret A, Andro-Garçon MC, Chauvel J, et al. Osmolality of a fortified human preterm milk: The effect of fortifier dosage, gestational age, lactation stage, and hospital practices. Arch Pediatr. 2018;25(7):411-415.
Sauret, A., Andro-Garçon, M. C., Chauvel, J., Ligneul, A., Dupas, P., Fressange-Mazda, C., Le Ruyet, P., & Dabadie, A. (2018). Osmolality of a fortified human preterm milk: The effect of fortifier dosage, gestational age, lactation stage, and hospital practices. Archives De Pediatrie : Organe Officiel De La Societe Francaise De Pediatrie, 25(7), 411-415. https://doi.org/10.1016/j.arcped.2018.08.006
Sauret A, et al. Osmolality of a Fortified Human Preterm Milk: the Effect of Fortifier Dosage, Gestational Age, Lactation Stage, and Hospital Practices. Arch Pediatr. 2018;25(7):411-415. PubMed PMID: 30241780.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Osmolality of a fortified human preterm milk: The effect of fortifier dosage, gestational age, lactation stage, and hospital practices. AU - Sauret,A, AU - Andro-Garçon,M-C, AU - Chauvel,J, AU - Ligneul,A, AU - Dupas,P, AU - Fressange-Mazda,C, AU - Le Ruyet,P, AU - Dabadie,A, Y1 - 2018/09/18/ PY - 2018/01/18/received PY - 2018/06/20/revised PY - 2018/08/18/accepted PY - 2018/9/23/pubmed PY - 2018/12/12/medline PY - 2018/9/23/entrez KW - Fortifier KW - Freezing KW - Human milk KW - Osmolality KW - Pasteurization SP - 411 EP - 415 JF - Archives de pediatrie : organe officiel de la Societe francaise de pediatrie JO - Arch Pediatr VL - 25 IS - 7 N2 - OBJECTIVE: The purpose of this study was to evaluate the dose-dependent effect of human milk fortifier (HMF) on the osmolality of various preterm human milks (PHMs) at different gestational and lactation stages, and with different storage and treatment conditions that are routinely used in neonatal intensive care units (NICUs). STUDY DESIGN: Twenty-four mothers who had given birth to their baby before 28 or between 29 and 31 weeks of pregnancy participated in the study after 1-2 weeks or 3-4 weeks breastfeeding after delivery. The study was a prospective, multicenter, comparative, and noninterventional study. Osmolality of fresh or pasteurized human milk stored at 4°C was measured (cryoscopy) at baseline, and 24hours after adding Suppletine® Human Milk fortifier (SHMF) at 3%, 4%, 4.5%, and 5% (w/v). RESULTS: PHM without supplementation had an osmolality (mean±SD) of 301±8 mOsm/kgH2O (n=40; 95% CI: [298; 303]). Adding 3-5% SHMF induced a linear increase of osmolality (P<0.001; r2=0.975). With 4% SHMF, the osmolality measure was 443±13mOsm/kg H2O (95% CI: [439-447]). Neither a 24-hour storage at 4°C nor pasteurization induced a modification of osmolality compared to the fresh samples. CONCLUSION: Whatever the origin and quality of milk as well as hospital practices, adding up to 4% (w/v) SHMF to PHM increases its nutritional quality and osmolality without exceeding 450mOsm/kgH2O, which is generally recognized as safe. SN - 1769-664X UR - https://www.unboundmedicine.com/medline/citation/30241780/Osmolality_of_a_fortified_human_preterm_milk:_The_effect_of_fortifier_dosage_gestational_age_lactation_stage_and_hospital_practices_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0929-693X(18)30175-1 DB - PRIME DP - Unbound Medicine ER -