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Migraine and cluster headache - the common link.
J Headache Pain. 2018 Sep 21; 19(1):89.JH

Abstract

Although clinically distinguishable, migraine and cluster headache share prominent features such as unilateral pain, common pharmacological triggers such glyceryl trinitrate, histamine, calcitonin gene-related peptide (CGRP) and response to triptans and neuromodulation. Recent data also suggest efficacy of anti CGRP monoclonal antibodies in both migraine and cluster headache. While exact mechanisms behind both disorders remain to be fully understood, the trigeminovascular system represents one possible common pathophysiological pathway and network of both disorders. Here, we review past and current literature shedding light on similarities and differences in phenotype, heritability, pathophysiology, imaging findings and treatment options of migraine and cluster headache. A continued focus on their shared pathophysiological pathways may be important in paving future treatment avenues that could benefit both migraine and cluster headache patients.

Authors+Show Affiliations

Danish Headache Center and Department of Neurology, Rigshospitalet Glostrup, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.Health Sciences Department, University of Florence and Headache Centre, Careggi University Hospital, Florence, Italy.Department of Medico-Surgical Sciences and Biotechnologies, Sapienza, University of Rome, Polo Pontino, Latina, Italy.Dep Internal Medicine, Division of Vascular Pharmacology, Erasmus Medical Center, Rotterdam, The Netherlands.Child Neuropsichiatry Unit, University of Palermo, Palermo, Italy.Medical Toxicology, Headache and Drug Abuse Center, University of Modena and Reggio Emilia, Modena, Italy.Neurology Clinic, University of Perugia - S.M. Misericordiae Hospital, Perugia, Italy.Danish Headache Center and Department of Neurology, Rigshospitalet Glostrup, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.Department of Neurogeriatric Medicine, Headache Medical Center Linz, Ordensklinikum Linz Barmherzige Schwestern, Seilerstaette 4, 4010, Linz, Austria. christian.lampl@ordensklinikum.at.No affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

30242519

Citation

Vollesen, Anne Luise, et al. "Migraine and Cluster Headache - the Common Link." The Journal of Headache and Pain, vol. 19, no. 1, 2018, p. 89.
Vollesen AL, Benemei S, Cortese F, et al. Migraine and cluster headache - the common link. J Headache Pain. 2018;19(1):89.
Vollesen, A. L., Benemei, S., Cortese, F., Labastida-Ramírez, A., Marchese, F., Pellesi, L., Romoli, M., Ashina, M., & Lampl, C. (2018). Migraine and cluster headache - the common link. The Journal of Headache and Pain, 19(1), 89. https://doi.org/10.1186/s10194-018-0909-4
Vollesen AL, et al. Migraine and Cluster Headache - the Common Link. J Headache Pain. 2018 Sep 21;19(1):89. PubMed PMID: 30242519.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Migraine and cluster headache - the common link. AU - Vollesen,Anne Luise, AU - Benemei,Silvia, AU - Cortese,Francesca, AU - Labastida-Ramírez,Alejandro, AU - Marchese,Francesca, AU - Pellesi,Lanfranco, AU - Romoli,Michele, AU - Ashina,Messoud, AU - Lampl,Christian, AU - ,, Y1 - 2018/09/21/ PY - 2018/06/14/received PY - 2018/08/20/accepted PY - 2018/9/23/entrez PY - 2018/9/23/pubmed PY - 2018/12/12/medline KW - Anti-CGRP (receptor) monoclonal antibodies – mAbs KW - Calcitonin gene-related peptide (CGRP) KW - Cluster headache KW - Hypothalamus KW - Migraine KW - Neuromodulation KW - Trigeminovascular system SP - 89 EP - 89 JF - The journal of headache and pain JO - J Headache Pain VL - 19 IS - 1 N2 - Although clinically distinguishable, migraine and cluster headache share prominent features such as unilateral pain, common pharmacological triggers such glyceryl trinitrate, histamine, calcitonin gene-related peptide (CGRP) and response to triptans and neuromodulation. Recent data also suggest efficacy of anti CGRP monoclonal antibodies in both migraine and cluster headache. While exact mechanisms behind both disorders remain to be fully understood, the trigeminovascular system represents one possible common pathophysiological pathway and network of both disorders. Here, we review past and current literature shedding light on similarities and differences in phenotype, heritability, pathophysiology, imaging findings and treatment options of migraine and cluster headache. A continued focus on their shared pathophysiological pathways may be important in paving future treatment avenues that could benefit both migraine and cluster headache patients. SN - 1129-2377 UR - https://www.unboundmedicine.com/medline/citation/30242519/Migraine_and_cluster_headache___the_common_link_ L2 - https://thejournalofheadacheandpain.biomedcentral.com/articles/10.1186/s10194-018-0909-4 DB - PRIME DP - Unbound Medicine ER -