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Sputum exosomes: promising biomarkers for idiopathic pulmonary fibrosis.
Thorax. 2019 03; 74(3):309-312.T

Abstract

Idiopathic pulmonary fibrosis (IPF) is a progressive fibrosing interstitial lung disease of unknown aetiology which leads rapidly to death. As diagnosis of IPF is complex, we aimed to characterise microRNA (miRNA) content of exosomes from sputum of patients with IPF. Using miRNA quantitative PCR array, we found a substantial dysregulation of sputum exosomal miRNA levels between patients with IPF and healthy subjects and identified a unique signature of three miRNAs. Interestingly, we found a negative correlation between miR-142-3p and diffusing capacity of the lungs for carbon monoxide/alveolar volume. This is the first characterisation of miRNA content of sputum-derived exosomes in IPF that identified promising biomarkers for diagnosis and disease severity.

Authors+Show Affiliations

Laboratory of Molecular Angiogenesis, GIGA-R, University of Liège, Liège, Belgium.Pneumology Department, CHU Liège, Liège, Belgium. Laboratory of Pneumology, GIGA-I3, University of Liège, Liège, Belgium.Pneumology Department, CHU Liège, Liège, Belgium. Laboratory of Pneumology, GIGA-I3, University of Liège, Liège, Belgium.Laboratory of Molecular Angiogenesis, GIGA-R, University of Liège, Liège, Belgium.Laboratoire de Biologie Cellulaire et Tissulaire, GIGA-R, University of Liège, Liège, Belgium.Laboratoire de Signalisation et Interactions des Protéines, GIGA-R, University of Liège, Liège, Belgium.Pneumology Department, CHU Liège, Liège, Belgium. Laboratory of Pneumology, GIGA-I3, University of Liège, Liège, Belgium.Pneumology Department, CHU Liège, Liège, Belgium. Laboratory of Pneumology, GIGA-I3, University of Liège, Liège, Belgium.Laboratory of Molecular Angiogenesis, GIGA-R, University of Liège, Liège, Belgium.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

30244194

Citation

Njock, Makon-Sébastien, et al. "Sputum Exosomes: Promising Biomarkers for Idiopathic Pulmonary Fibrosis." Thorax, vol. 74, no. 3, 2019, pp. 309-312.
Njock MS, Guiot J, Henket MA, et al. Sputum exosomes: promising biomarkers for idiopathic pulmonary fibrosis. Thorax. 2019;74(3):309-312.
Njock, M. S., Guiot, J., Henket, M. A., Nivelles, O., Thiry, M., Dequiedt, F., Corhay, J. L., Louis, R. E., & Struman, I. (2019). Sputum exosomes: promising biomarkers for idiopathic pulmonary fibrosis. Thorax, 74(3), 309-312. https://doi.org/10.1136/thoraxjnl-2018-211897
Njock MS, et al. Sputum Exosomes: Promising Biomarkers for Idiopathic Pulmonary Fibrosis. Thorax. 2019;74(3):309-312. PubMed PMID: 30244194.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Sputum exosomes: promising biomarkers for idiopathic pulmonary fibrosis. AU - Njock,Makon-Sébastien, AU - Guiot,Julien, AU - Henket,Monique A, AU - Nivelles,Olivier, AU - Thiry,Marc, AU - Dequiedt,Franck, AU - Corhay,Jean-Louis, AU - Louis,Renaud E, AU - Struman,Ingrid, Y1 - 2018/09/22/ PY - 2018/04/04/received PY - 2018/08/24/revised PY - 2018/08/27/accepted PY - 2018/9/24/pubmed PY - 2019/5/16/medline PY - 2018/9/24/entrez KW - idiopathic pulmonary fibrosis KW - interstitial fibrosis SP - 309 EP - 312 JF - Thorax JO - Thorax VL - 74 IS - 3 N2 - Idiopathic pulmonary fibrosis (IPF) is a progressive fibrosing interstitial lung disease of unknown aetiology which leads rapidly to death. As diagnosis of IPF is complex, we aimed to characterise microRNA (miRNA) content of exosomes from sputum of patients with IPF. Using miRNA quantitative PCR array, we found a substantial dysregulation of sputum exosomal miRNA levels between patients with IPF and healthy subjects and identified a unique signature of three miRNAs. Interestingly, we found a negative correlation between miR-142-3p and diffusing capacity of the lungs for carbon monoxide/alveolar volume. This is the first characterisation of miRNA content of sputum-derived exosomes in IPF that identified promising biomarkers for diagnosis and disease severity. SN - 1468-3296 UR - https://www.unboundmedicine.com/medline/citation/30244194/Sputum_exosomes:_promising_biomarkers_for_idiopathic_pulmonary_fibrosis_ L2 - http://thorax.bmj.com/cgi/pmidlookup?view=long&pmid=30244194 DB - PRIME DP - Unbound Medicine ER -