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Detection and Quantitation of Trace Fentanyl in Heroin by Surface-Enhanced Raman Spectroscopy.
Anal Chem. 2018 11 06; 90(21):12678-12685.AC

Abstract

The identification of fentanyl, a main culprit in opioid overdose deaths, has become critical. Whereas Raman spectroscopy is an effective tool for detecting illicit drugs, the weak intensity of Raman scattering can make it difficult to distinguish trace materials. This shortcoming is addressed by surface-enhanced Raman spectroscopy (SERS), which produces strong signal enhancements when target compounds are near metal nanoparticles. This work examines the use of a paper-based substrate impregnated with silver nanoparticles for the detection of trace quantities of fentanyl alone and as an adulterant in heroin. In addition, intensity ratios of diagnostic peaks associated with each substance were fitted to a Langmuir isotherm calibration model and used for the quantitative analysis of fentanyl in heroin mixtures. Linearity was observed at <6% fentanyl, a significant finding that is consistent with concentrations found in drugs seized during law enforcement efforts. In addition, swabbing with these paper-based SERS substrates facilitated the recovery of fentanyl from surfaces, showing this to be applicable for crime scene investigations. However, assessment using the calibration model proved difficult for swabbed samples. Overall, this work demonstrates a potentially simple and sensitive technique for the forensic analysis and quantitation of fentanyl in trace amounts.

Authors+Show Affiliations

Ph.D. Program in Chemistry , City University of New York Graduate School and University Center , 365 Fifth Avenue , New York , New York 10016 , United States. Department of Chemistry , City University of New York, City College of New York , 160 Convent Avenue , New York , New York 10031 , United States.Ph.D. Program in Criminal Justice, Forensic Science Specialization , City University of New York, John Jay College of Criminal Justice , 524 West 59th Street , New York , New York 10019 , United States.Ionica Sciences, Inc., McGovern Center for Venture Development in the Life Sciences , 413 Weill Hall, 526 North Campus Drive , Ithaca , New York 14853 , United States.Ph.D. Program in Criminal Justice, Forensic Science Specialization , City University of New York, John Jay College of Criminal Justice , 524 West 59th Street , New York , New York 10019 , United States.Department of Chemistry , City University of New York, City College of New York , 160 Convent Avenue , New York , New York 10031 , United States.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.

Language

eng

PubMed ID

30247896

Citation

Haddad, Abed, et al. "Detection and Quantitation of Trace Fentanyl in Heroin By Surface-Enhanced Raman Spectroscopy." Analytical Chemistry, vol. 90, no. 21, 2018, pp. 12678-12685.
Haddad A, Comanescu MA, Green O, et al. Detection and Quantitation of Trace Fentanyl in Heroin by Surface-Enhanced Raman Spectroscopy. Anal Chem. 2018;90(21):12678-12685.
Haddad, A., Comanescu, M. A., Green, O., Kubic, T. A., & Lombardi, J. R. (2018). Detection and Quantitation of Trace Fentanyl in Heroin by Surface-Enhanced Raman Spectroscopy. Analytical Chemistry, 90(21), 12678-12685. https://doi.org/10.1021/acs.analchem.8b02909
Haddad A, et al. Detection and Quantitation of Trace Fentanyl in Heroin By Surface-Enhanced Raman Spectroscopy. Anal Chem. 2018 11 6;90(21):12678-12685. PubMed PMID: 30247896.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Detection and Quantitation of Trace Fentanyl in Heroin by Surface-Enhanced Raman Spectroscopy. AU - Haddad,Abed, AU - Comanescu,Mircea A, AU - Green,Omar, AU - Kubic,Thomas A, AU - Lombardi,John R, Y1 - 2018/10/08/ PY - 2018/9/25/pubmed PY - 2019/4/30/medline PY - 2018/9/25/entrez SP - 12678 EP - 12685 JF - Analytical chemistry JO - Anal Chem VL - 90 IS - 21 N2 - The identification of fentanyl, a main culprit in opioid overdose deaths, has become critical. Whereas Raman spectroscopy is an effective tool for detecting illicit drugs, the weak intensity of Raman scattering can make it difficult to distinguish trace materials. This shortcoming is addressed by surface-enhanced Raman spectroscopy (SERS), which produces strong signal enhancements when target compounds are near metal nanoparticles. This work examines the use of a paper-based substrate impregnated with silver nanoparticles for the detection of trace quantities of fentanyl alone and as an adulterant in heroin. In addition, intensity ratios of diagnostic peaks associated with each substance were fitted to a Langmuir isotherm calibration model and used for the quantitative analysis of fentanyl in heroin mixtures. Linearity was observed at <6% fentanyl, a significant finding that is consistent with concentrations found in drugs seized during law enforcement efforts. In addition, swabbing with these paper-based SERS substrates facilitated the recovery of fentanyl from surfaces, showing this to be applicable for crime scene investigations. However, assessment using the calibration model proved difficult for swabbed samples. Overall, this work demonstrates a potentially simple and sensitive technique for the forensic analysis and quantitation of fentanyl in trace amounts. SN - 1520-6882 UR - https://www.unboundmedicine.com/medline/citation/30247896/Detection_and_Quantitation_of_Trace_Fentanyl_in_Heroin_by_Surface_Enhanced_Raman_Spectroscopy_ L2 - https://doi.org/10.1021/acs.analchem.8b02909 DB - PRIME DP - Unbound Medicine ER -