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Investigating Voice as a Biomarker for Leucine-Rich Repeat Kinase 2-Associated Parkinson's Disease.
J Parkinsons Dis 2018; 8(4):503-510JP

Abstract

We investigate the potential association between leucine-rich repeat kinase 2 (LRRK2) mutations and voice. Sustained phonations ('aaah' sounds) were recorded from 7 individuals with LRRK2-associated Parkinson's disease (PD), 17 participants with idiopathic PD (iPD), 20 non-manifesting LRRK2-mutation carriers, 25 related non-carriers, and 26 controls. In distinguishing LRRK2-associated PD and iPD, the mean sensitivity was 95.4% (SD 17.8%) and mean specificity was 89.6% (SD 26.5%). Voice features for non-manifesting carriers, related non-carriers, and controls were much less discriminatory. Vocal deficits in LRRK2-associated PD may be different than those in iPD. These preliminary results warrant longitudinal analyses and replication in larger cohorts.

Authors+Show Affiliations

Somerville College, University of Oxford, Oxford, UK.The Edmond J. Safra Program in Parkinson's Disease and the Morton and Gloria Shulman Movement Disorders Centre and, Toronto Western Hospital, Toronto, ON, Canada.Department of Medicine, Parkinson's Disease and Movement Disorders Center, Division of Neurology, The Ottawa Hospital Research Institute, University of Ottawa Brain and Mind Institute, Ottawa, Canada.Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, UK.The Edmond J. Safra Program in Parkinson's Disease and the Morton and Gloria Shulman Movement Disorders Centre and, Toronto Western Hospital, Toronto, ON, Canada.Department of Medicine, Division of Neurology, Hamilton Health Sciences, McMaster University, Hamilton, ON, Canada.The Edmond J. Safra Program in Parkinson's Disease and the Morton and Gloria Shulman Movement Disorders Centre and, Toronto Western Hospital, Toronto, ON, Canada.Department of Neurology, Movement Disorders Center, University of Colorado, Anschutz Medical Campus, Aurora, CO, USA.The Edmond J. Safra Program in Parkinson's Disease and the Morton and Gloria Shulman Movement Disorders Centre and, Toronto Western Hospital, Toronto, ON, Canada.The Edmond J. Safra Program in Parkinson's Disease and the Morton and Gloria Shulman Movement Disorders Centre and, Toronto Western Hospital, Toronto, ON, Canada.The Edmond J. Safra Program in Parkinson's Disease and the Morton and Gloria Shulman Movement Disorders Centre and, Toronto Western Hospital, Toronto, ON, Canada.The Edmond J. Safra Program in Parkinson's Disease and the Morton and Gloria Shulman Movement Disorders Centre and, Toronto Western Hospital, Toronto, ON, Canada.Engineering and Applied Science, Aston University, Birmingham, UK. Media Lab, Massachusetts Institute of Technology, Cambridge, MA, USA.The Edmond J. Safra Program in Parkinson's Disease and the Morton and Gloria Shulman Movement Disorders Centre and, Toronto Western Hospital, Toronto, ON, Canada.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

30248062

Citation

Arora, Siddharth, et al. "Investigating Voice as a Biomarker for Leucine-Rich Repeat Kinase 2-Associated Parkinson's Disease." Journal of Parkinson's Disease, vol. 8, no. 4, 2018, pp. 503-510.
Arora S, Visanji NP, Mestre TA, et al. Investigating Voice as a Biomarker for Leucine-Rich Repeat Kinase 2-Associated Parkinson's Disease. J Parkinsons Dis. 2018;8(4):503-510.
Arora, S., Visanji, N. P., Mestre, T. A., Tsanas, A., AlDakheel, A., Connolly, B. S., ... Marras, C. (2018). Investigating Voice as a Biomarker for Leucine-Rich Repeat Kinase 2-Associated Parkinson's Disease. Journal of Parkinson's Disease, 8(4), pp. 503-510. doi:10.3233/JPD-181389.
Arora S, et al. Investigating Voice as a Biomarker for Leucine-Rich Repeat Kinase 2-Associated Parkinson's Disease. J Parkinsons Dis. 2018;8(4):503-510. PubMed PMID: 30248062.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Investigating Voice as a Biomarker for Leucine-Rich Repeat Kinase 2-Associated Parkinson's Disease. AU - Arora,Siddharth, AU - Visanji,Naomi P, AU - Mestre,Tiago A, AU - Tsanas,Athanasios, AU - AlDakheel,Amaal, AU - Connolly,Barbara S, AU - Gasca-Salas,Carmen, AU - Kern,Drew S, AU - Jain,Jennifer, AU - Slow,Elizabeth J, AU - Faust-Socher,Achinoam, AU - Lang,Anthony E, AU - Little,Max A, AU - Marras,Connie, PY - 2018/9/25/pubmed PY - 2019/10/18/medline PY - 2018/9/25/entrez KW - LRRK2 mutation KW - Parkinson’s disease KW - biomarker KW - voice SP - 503 EP - 510 JF - Journal of Parkinson's disease JO - J Parkinsons Dis VL - 8 IS - 4 N2 - We investigate the potential association between leucine-rich repeat kinase 2 (LRRK2) mutations and voice. Sustained phonations ('aaah' sounds) were recorded from 7 individuals with LRRK2-associated Parkinson's disease (PD), 17 participants with idiopathic PD (iPD), 20 non-manifesting LRRK2-mutation carriers, 25 related non-carriers, and 26 controls. In distinguishing LRRK2-associated PD and iPD, the mean sensitivity was 95.4% (SD 17.8%) and mean specificity was 89.6% (SD 26.5%). Voice features for non-manifesting carriers, related non-carriers, and controls were much less discriminatory. Vocal deficits in LRRK2-associated PD may be different than those in iPD. These preliminary results warrant longitudinal analyses and replication in larger cohorts. SN - 1877-718X UR - https://www.unboundmedicine.com/medline/citation/30248062/Investigating_Voice_as_a_Biomarker_for_Leucine_Rich_Repeat_Kinase_2_Associated_Parkinson's_Disease_ L2 - https://content.iospress.com/openurl?genre=article&id=doi:10.3233/JPD-181389 DB - PRIME DP - Unbound Medicine ER -