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Monitoring arbovirus in Thailand: Surveillance of dengue, chikungunya and zika virus, with a focus on coinfections.
Acta Trop. 2018 Dec; 188:244-250.AT

Abstract

Infections caused by arboviruses such as dengue virus (DENV), chikungunya virus (CHIKV), and Zika virus (ZIKV) frequently occur in tropical and subtropical regions. These three viruses are transmitted by Aedes (Ae.) aegypti and Ae. albopictus. In Thailand, the highest incidence of arbovirus infection and the high circulation of Aedes mosquito mainly occurs in the Southern provinces of the country. Few studies have focused on the incidence of co-infection of arboviruses in this region. In the present study, a cross-sectional study was conducted on a cohort of 182 febrile patients from three hospitals located in Southern Thailand. Surveillance of DENV, CHIKV and ZIKV was conducted from May to October 2016 during the rainy season. The serological analysis and molecular detection of arboviruses were performed by ELISA and multiplex RT-PCR respectively. The results demonstrated that 163 cases out of 182 patients (89.56%) were infected with DENV, with a predominance of DENV-2. Among these DENV positive cases, a co-infection with CHIKV for 6 patients (3.68%) and with ZIKV for 1 patient (0.61%) were found. 19 patients out of 182 were negative for arboviruses. This study provides evidence of co-infection of arboviruses in Southern Thailand and highlight the importance of testing DENV and other medically important arboviruses, such as CHIKV and ZIKV simultaneously.

Authors+Show Affiliations

Department of Microbiology and Immunology, Faculty of Tropical Medicine, Mahidol University, Thailand.Department of Pathology, Faculty of Medicine, Prince of Songkhla University, Thailand.Department of Tropical Hygiene, Faculty of Tropical Medicine, Mahidol University, Thailand.MIVEGEC UMR 224, Univ Montpellier, IRD, CNRS, Montpellier, France.Department of Tropical Hygiene, Faculty of Tropical Medicine, Mahidol University, Thailand.MIVEGEC UMR 224, Univ Montpellier, IRD, CNRS, Montpellier, France.Department of Microbiology and Immunology, Faculty of Tropical Medicine, Mahidol University, Thailand. Electronic address: natthanej.lup@mahidol.ac.th.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

30248317

Citation

Suwanmanee, San, et al. "Monitoring Arbovirus in Thailand: Surveillance of Dengue, Chikungunya and Zika Virus, With a Focus On Coinfections." Acta Tropica, vol. 188, 2018, pp. 244-250.
Suwanmanee S, Surasombatpattana P, Soonthornworasiri N, et al. Monitoring arbovirus in Thailand: Surveillance of dengue, chikungunya and zika virus, with a focus on coinfections. Acta Trop. 2018;188:244-250.
Suwanmanee, S., Surasombatpattana, P., Soonthornworasiri, N., Hamel, R., Maneekan, P., Missé, D., & Luplertlop, N. (2018). Monitoring arbovirus in Thailand: Surveillance of dengue, chikungunya and zika virus, with a focus on coinfections. Acta Tropica, 188, 244-250. https://doi.org/10.1016/j.actatropica.2018.09.012
Suwanmanee S, et al. Monitoring Arbovirus in Thailand: Surveillance of Dengue, Chikungunya and Zika Virus, With a Focus On Coinfections. Acta Trop. 2018;188:244-250. PubMed PMID: 30248317.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Monitoring arbovirus in Thailand: Surveillance of dengue, chikungunya and zika virus, with a focus on coinfections. AU - Suwanmanee,San, AU - Surasombatpattana,Pornnapat, AU - Soonthornworasiri,Ngamphol, AU - Hamel,Rodolphe, AU - Maneekan,Pannamas, AU - Missé,Dorothée, AU - Luplertlop,Natthanej, Y1 - 2018/09/21/ PY - 2018/04/06/received PY - 2018/09/08/revised PY - 2018/09/20/accepted PY - 2018/9/25/pubmed PY - 2018/12/12/medline PY - 2018/9/25/entrez KW - Arbovirus vector KW - Arboviruses KW - Co-infection KW - Mosquito vector KW - Mosquito-borne diseases SP - 244 EP - 250 JF - Acta tropica JO - Acta Trop VL - 188 N2 - Infections caused by arboviruses such as dengue virus (DENV), chikungunya virus (CHIKV), and Zika virus (ZIKV) frequently occur in tropical and subtropical regions. These three viruses are transmitted by Aedes (Ae.) aegypti and Ae. albopictus. In Thailand, the highest incidence of arbovirus infection and the high circulation of Aedes mosquito mainly occurs in the Southern provinces of the country. Few studies have focused on the incidence of co-infection of arboviruses in this region. In the present study, a cross-sectional study was conducted on a cohort of 182 febrile patients from three hospitals located in Southern Thailand. Surveillance of DENV, CHIKV and ZIKV was conducted from May to October 2016 during the rainy season. The serological analysis and molecular detection of arboviruses were performed by ELISA and multiplex RT-PCR respectively. The results demonstrated that 163 cases out of 182 patients (89.56%) were infected with DENV, with a predominance of DENV-2. Among these DENV positive cases, a co-infection with CHIKV for 6 patients (3.68%) and with ZIKV for 1 patient (0.61%) were found. 19 patients out of 182 were negative for arboviruses. This study provides evidence of co-infection of arboviruses in Southern Thailand and highlight the importance of testing DENV and other medically important arboviruses, such as CHIKV and ZIKV simultaneously. SN - 1873-6254 UR - https://www.unboundmedicine.com/medline/citation/30248317/Monitoring_arbovirus_in_Thailand:_Surveillance_of_dengue_chikungunya_and_zika_virus_with_a_focus_on_coinfections_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0001-706X(18)30427-3 DB - PRIME DP - Unbound Medicine ER -