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Severity-dependent and -independent brain regions of major depressive disorder: A long-term longitudinal near-infrared spectroscopy study.
J Affect Disord 2019; 243:249-254JA

Abstract

BACKGROUND

Long-term longitudinal studies are necessary to establish neuroimaging indicators which contribute to the detection of severity changes over time in patients with major depressive disorder (MDD).

METHODS

One hundred sixty-five patients with MDD underwent clinical assessments and near-infrared spectroscopy (NIRS) examination at the initial evaluation (T0). After 1.5 years, 45 patients who visited for the follow-up evaluation (T1.5) were included in the analysis. The authors conducted analyses using the 17-item Hamilton Rating Scale for Depression (HAMD) scores and mean oxy-hemoglobin concentration ([oxy-Hb]) changes during a cognitive task in NIRS at T0 (T0_HAMD, T0_[oxy-Hb]) and at T1.5 (T1.5_HAMD, T1.5_[oxy-Hb]), and their intra-individual longitudinal changes (ΔHAMD = T1.5_HAMD - T0_HAMD, Δ[oxy-Hb] = T1.5_[oxy-Hb] - T0_[oxy-Hb]).

RESULTS

For severity-dependent regions, the Δ[oxy-Hb] in the right inferior frontal gyrus (IFG) was negatively correlated with the ΔHAMD. For severity-independent regions, the intra-class correlation coefficients between T0_ and T1.5_[oxy-Hb] were moderate in the bilateral middle frontal gyri (MFG).

LIMITATIONS

The percentage of patients included in the follow-up examination was relatively small.

CONCLUSIONS

Brain activation in the right IFG and the bilateral MFG as measured by NIRS may differentially indicate clinical severity and trait-related abnormalities in MDD.

Authors+Show Affiliations

Department of Neuropsychiatry, Graduate School of Medicine, The University of Tokyo, 7-3-1, Hongo, Bunkyo-ku, Tokyo 113-8655, Japan. Electronic address: satomura-y@umin.net.Department of Neuropsychiatry, Graduate School of Medicine, The University of Tokyo, 7-3-1, Hongo, Bunkyo-ku, Tokyo 113-8655, Japan. Electronic address: sakakibara-tky@umin.ac.jp.Department of Neuropsychiatry, Graduate School of Medicine, The University of Tokyo, 7-3-1, Hongo, Bunkyo-ku, Tokyo 113-8655, Japan; Department of Clinical Psychology, Graduate School of Education, The University of Tokyo, 7-3-1, Hongo, Bunkyo-ku, Tokyo 113-0033, Japan; MRC Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London SE5 8AF, UK. Electronic address: takizawar-tky@umin.ac.jp.Department of Neuropsychiatry, Graduate School of Medicine, The University of Tokyo, 7-3-1, Hongo, Bunkyo-ku, Tokyo 113-8655, Japan; University of Tokyo Institute for Diversity & Adaptation of Human Mind (UTIDAHM), 3-8-1 Komaba, Meguro-ku, Tokyo 153-8902, Japan; Center for Evolutionary Cognitive Sciences, Graduate School of Art and Sciences, The University of Tokyo, 3-8-1 Komaba, Meguro-ku, Tokyo 153-8902, Japan. Electronic address: skoike-tky@umin.ac.jp.Department of Neuropsychiatry, Graduate School of Medicine, The University of Tokyo, 7-3-1, Hongo, Bunkyo-ku, Tokyo 113-8655, Japan. Electronic address: ynishimu-mie@umin.ac.jp.Department of Neuropsychiatry, Graduate School of Medicine, The University of Tokyo, 7-3-1, Hongo, Bunkyo-ku, Tokyo 113-8655, Japan. Electronic address: sakuradah-tky@umin.ac.jp.Department of Neuropsychiatry, Graduate School of Medicine, The University of Tokyo, 7-3-1, Hongo, Bunkyo-ku, Tokyo 113-8655, Japan. Electronic address: yamagishimk-tky@umin.ac.jp.Department of Neuropsychiatry, Graduate School of Medicine, The University of Tokyo, 7-3-1, Hongo, Bunkyo-ku, Tokyo 113-8655, Japan.Department of Neuropsychiatry, Graduate School of Medicine, The University of Tokyo, 7-3-1, Hongo, Bunkyo-ku, Tokyo 113-8655, Japan; Application Development Office, Hitachi Medical Corporation, 2-1 Shintoyofuta, Kashiwa City, Chiba 277-0804, Japan. Electronic address: shingo.kawasaki.op@hitachi.com.Department of Neuropsychiatry, Graduate School of Medicine, The University of Tokyo, 7-3-1, Hongo, Bunkyo-ku, Tokyo 113-8655, Japan. Electronic address: nokada-tky@umin.ac.jp.Department of Neuropsychiatry, Graduate School of Medicine, The University of Tokyo, 7-3-1, Hongo, Bunkyo-ku, Tokyo 113-8655, Japan.Department of Neuropsychiatry, Graduate School of Medicine, The University of Tokyo, 7-3-1, Hongo, Bunkyo-ku, Tokyo 113-8655, Japan. Electronic address: kaki-tky@umin.ac.jp.Department of Neuropsychiatry, Graduate School of Medicine, The University of Tokyo, 7-3-1, Hongo, Bunkyo-ku, Tokyo 113-8655, Japan. Electronic address: jind-tky@umin.ac.jp.Department of Neuropsychiatry, Graduate School of Medicine, The University of Tokyo, 7-3-1, Hongo, Bunkyo-ku, Tokyo 113-8655, Japan. Electronic address: kondo-psy@umin.ac.jp.Department of Neuropsychiatry, Graduate School of Medicine, The University of Tokyo, 7-3-1, Hongo, Bunkyo-ku, Tokyo 113-8655, Japan. Electronic address: kasaik-tky@umin.net.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

30248636

Citation

Satomura, Yoshihiro, et al. "Severity-dependent and -independent Brain Regions of Major Depressive Disorder: a Long-term Longitudinal Near-infrared Spectroscopy Study." Journal of Affective Disorders, vol. 243, 2019, pp. 249-254.
Satomura Y, Sakakibara E, Takizawa R, et al. Severity-dependent and -independent brain regions of major depressive disorder: A long-term longitudinal near-infrared spectroscopy study. J Affect Disord. 2019;243:249-254.
Satomura, Y., Sakakibara, E., Takizawa, R., Koike, S., Nishimura, Y., Sakurada, H., ... Kasai, K. (2019). Severity-dependent and -independent brain regions of major depressive disorder: A long-term longitudinal near-infrared spectroscopy study. Journal of Affective Disorders, 243, pp. 249-254. doi:10.1016/j.jad.2018.09.029.
Satomura Y, et al. Severity-dependent and -independent Brain Regions of Major Depressive Disorder: a Long-term Longitudinal Near-infrared Spectroscopy Study. J Affect Disord. 2019 01 15;243:249-254. PubMed PMID: 30248636.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Severity-dependent and -independent brain regions of major depressive disorder: A long-term longitudinal near-infrared spectroscopy study. AU - Satomura,Yoshihiro, AU - Sakakibara,Eisuke, AU - Takizawa,Ryu, AU - Koike,Shinsuke, AU - Nishimura,Yukika, AU - Sakurada,Hanako, AU - Yamagishi,Mika, AU - Shimojo,Chie, AU - Kawasaki,Shingo, AU - Okada,Naohiro, AU - Matsuoka,Jun, AU - Kinoshita,Akihide, AU - Jinde,Seiichiro, AU - Kondo,Shinsuke, AU - Kasai,Kiyoto, Y1 - 2018/09/17/ PY - 2018/05/05/received PY - 2018/08/12/revised PY - 2018/09/15/accepted PY - 2018/9/25/pubmed PY - 2019/2/28/medline PY - 2018/9/25/entrez KW - Abbreviations: MDD, major depressive disorder KW - Biological marker KW - CBF, cerebral blood flow KW - CH, channel KW - DSM-IV, Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition KW - FDR, false-discovery rate KW - GAF, Global Assessment of Functioning KW - HAMD, Hamilton Rating Scale for Depression KW - ICCs, intra-class correlation coefficients KW - IFG, inferior frontal gyrus KW - IQ, Intelligence Quotient KW - JART, Japanese Adult Reading Test KW - Long-term longitudinal study KW - MFG, middle frontal gyrus KW - MRI, magnetic resonance imaging KW - Major depressive disorder (MDD) KW - Mood disorder KW - NIRS, near-infrared spectroscopy KW - Near-infrared spectroscopy (NIRS) KW - PET, positron emission tomography KW - PFC, prefrontal cortex KW - SCID, Structured Clinical Interview for DSM-IV KW - VFT, verbal fluency test SP - 249 EP - 254 JF - Journal of affective disorders JO - J Affect Disord VL - 243 N2 - BACKGROUND: Long-term longitudinal studies are necessary to establish neuroimaging indicators which contribute to the detection of severity changes over time in patients with major depressive disorder (MDD). METHODS: One hundred sixty-five patients with MDD underwent clinical assessments and near-infrared spectroscopy (NIRS) examination at the initial evaluation (T0). After 1.5 years, 45 patients who visited for the follow-up evaluation (T1.5) were included in the analysis. The authors conducted analyses using the 17-item Hamilton Rating Scale for Depression (HAMD) scores and mean oxy-hemoglobin concentration ([oxy-Hb]) changes during a cognitive task in NIRS at T0 (T0_HAMD, T0_[oxy-Hb]) and at T1.5 (T1.5_HAMD, T1.5_[oxy-Hb]), and their intra-individual longitudinal changes (ΔHAMD = T1.5_HAMD - T0_HAMD, Δ[oxy-Hb] = T1.5_[oxy-Hb] - T0_[oxy-Hb]). RESULTS: For severity-dependent regions, the Δ[oxy-Hb] in the right inferior frontal gyrus (IFG) was negatively correlated with the ΔHAMD. For severity-independent regions, the intra-class correlation coefficients between T0_ and T1.5_[oxy-Hb] were moderate in the bilateral middle frontal gyri (MFG). LIMITATIONS: The percentage of patients included in the follow-up examination was relatively small. CONCLUSIONS: Brain activation in the right IFG and the bilateral MFG as measured by NIRS may differentially indicate clinical severity and trait-related abnormalities in MDD. SN - 1573-2517 UR - https://www.unboundmedicine.com/medline/citation/30248636/Severity_dependent_and__independent_brain_regions_of_major_depressive_disorder:_A_long_term_longitudinal_near_infrared_spectroscopy_study_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0165-0327(18)30960-1 DB - PRIME DP - Unbound Medicine ER -