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2-fluoro-2-deoxy-D-glucose positron emission tomography versus conventional imaging for the diagnosis of breast cancer and lymph node metastases.
J Cancer Res Ther. 2018 Sep; 14(Supplement):S661-S666.JC

Abstract

Context

Proper preoperative staging is vital in the treatment of breast cancer patients. Fluorine-18-labeled 2-fluoro-2-deoxy-D-glucose positron emission tomography/computed tomography (18F-FDG-PET/CT) and conventional diagnostic modalities including ultrasonography (US), mammography (MG), and magnetic resonance imaging (MRI) play a greater role.

Aims

To evaluate the diagnostic accuracy of FDG-PET in detecting primary breast cancer as compared with US, MG, and MRI, and in axillary lymph nodes (ALNs) staging in Chinese women.

Settings and Design

It is a study of diagnostic accuracy.

Subjects and Methods

Thirty-one female patients, with biopsy established breast carcinoma, were recruited and analyzed retrospectively. All patients underwent 18F-FDG-PET, MG, US, and MRI. FDG-PET/CT for the diagnosis of primary breast cancer and detecting ALNs metastases were compared with MG, US, and MRI.

Statistical Analysis Used

Sensitivity, specificity, positive-predictive value (PPV), and negative-predictive value (NPV) of FDG-PET imaging for primary breast cancers and ALN staging were analyzed using standard statistical analyses.

Results

In 31 patients with cytologically established invasive breast carcinoma, the sensitivities of US, MG, MRI, and FDG-PET/CT were 90% (28/31), 84% (26/31), 97% (30/31), and 94% (29/31), respectively. The sensitivity, specificity, overall accuracy, PPV, and NPV of US, MRI, and FDG-PET/CT in ALN staging (maximum standardized uptake value cutoff at 1.5) were 80%, 86%, 84%, 80%, and 90%; 90%, 95%, 94%, 90%, and 95%; and 90%, 86%, 87%, 90%, and 95%, respectively.

Conclusions

US and MRI should remain the first line for the diagnosis of breast cancer. Both MRI and FDG-PET/CT could accurately diagnose the primary breast cancer and stage the axilla lymph nodes, but further large population study is needed.

Authors+Show Affiliations

Department of Surgery, Linyi People's Hospital, Linyi 276003, Shandong Province, China.Department of Surgery, Linyi People's Hospital, Linyi 276003, Shandong Province, China.Department of Nuclear Medicine, Jinhua Central Hospital, Jinhua Hospital of Zhejiang University, Jinhua 321000, Zhejiang, China.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

30249884

Citation

Shao, Mei, et al. "2-fluoro-2-deoxy-D-glucose Positron Emission Tomography Versus Conventional Imaging for the Diagnosis of Breast Cancer and Lymph Node Metastases." Journal of Cancer Research and Therapeutics, vol. 14, no. Supplement, 2018, pp. S661-S666.
Shao M, Zi J, Wen G. 2-fluoro-2-deoxy-D-glucose positron emission tomography versus conventional imaging for the diagnosis of breast cancer and lymph node metastases. J Cancer Res Ther. 2018;14(Supplement):S661-S666.
Shao, M., Zi, J., & Wen, G. (2018). 2-fluoro-2-deoxy-D-glucose positron emission tomography versus conventional imaging for the diagnosis of breast cancer and lymph node metastases. Journal of Cancer Research and Therapeutics, 14(Supplement), S661-S666. https://doi.org/10.4103/0973-1482.207069
Shao M, Zi J, Wen G. 2-fluoro-2-deoxy-D-glucose Positron Emission Tomography Versus Conventional Imaging for the Diagnosis of Breast Cancer and Lymph Node Metastases. J Cancer Res Ther. 2018;14(Supplement):S661-S666. PubMed PMID: 30249884.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - 2-fluoro-2-deoxy-D-glucose positron emission tomography versus conventional imaging for the diagnosis of breast cancer and lymph node metastases. AU - Shao,Mei, AU - Zi,Jinhua, AU - Wen,Guanghua, PY - 2018/9/26/entrez PY - 2018/9/27/pubmed PY - 2018/11/6/medline KW - 2-fluoro-2-deoxy-D-glucose positron emission tomography KW - breast cancer KW - magnetic resonance imaging KW - mammography KW - ultrasonography SP - S661 EP - S666 JF - Journal of cancer research and therapeutics JO - J Cancer Res Ther VL - 14 IS - Supplement N2 - Context: Proper preoperative staging is vital in the treatment of breast cancer patients. Fluorine-18-labeled 2-fluoro-2-deoxy-D-glucose positron emission tomography/computed tomography (18F-FDG-PET/CT) and conventional diagnostic modalities including ultrasonography (US), mammography (MG), and magnetic resonance imaging (MRI) play a greater role. Aims: To evaluate the diagnostic accuracy of FDG-PET in detecting primary breast cancer as compared with US, MG, and MRI, and in axillary lymph nodes (ALNs) staging in Chinese women. Settings and Design: It is a study of diagnostic accuracy. Subjects and Methods: Thirty-one female patients, with biopsy established breast carcinoma, were recruited and analyzed retrospectively. All patients underwent 18F-FDG-PET, MG, US, and MRI. FDG-PET/CT for the diagnosis of primary breast cancer and detecting ALNs metastases were compared with MG, US, and MRI. Statistical Analysis Used: Sensitivity, specificity, positive-predictive value (PPV), and negative-predictive value (NPV) of FDG-PET imaging for primary breast cancers and ALN staging were analyzed using standard statistical analyses. Results: In 31 patients with cytologically established invasive breast carcinoma, the sensitivities of US, MG, MRI, and FDG-PET/CT were 90% (28/31), 84% (26/31), 97% (30/31), and 94% (29/31), respectively. The sensitivity, specificity, overall accuracy, PPV, and NPV of US, MRI, and FDG-PET/CT in ALN staging (maximum standardized uptake value cutoff at 1.5) were 80%, 86%, 84%, 80%, and 90%; 90%, 95%, 94%, 90%, and 95%; and 90%, 86%, 87%, 90%, and 95%, respectively. Conclusions: US and MRI should remain the first line for the diagnosis of breast cancer. Both MRI and FDG-PET/CT could accurately diagnose the primary breast cancer and stage the axilla lymph nodes, but further large population study is needed. SN - 1998-4138 UR - https://www.unboundmedicine.com/medline/citation/30249884/2_fluoro_2_deoxy_D_glucose_positron_emission_tomography_versus_conventional_imaging_for_the_diagnosis_of_breast_cancer_and_lymph_node_metastases_ L2 - http://www.cancerjournal.net/article.asp?issn=0973-1482;year=2018;volume=14;issue=10;spage=661;epage=666;aulast=Shao DB - PRIME DP - Unbound Medicine ER -