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Beneficial effects of Gelsemium-based treatment against paclitaxel-induced painful symptoms.
Neurol Sci. 2018 Dec; 39(12):2183-2196.NS

Abstract

Chemotherapeutic drugs induce various side effects including painful peripheral neuropathy that represents a major concern. The widely used anticancer drug paclitaxel causes neurological side effects such as burning pain, allodynia, and hyperalgesia. Neuroprotective substances that may effectively counteract paclitaxel-induced neuropathic symptoms are needed. Here, we investigated the potential of Gelsemium sempervirens (GS) to counteract paclitaxel-evoked painful neuropathy in rats. Using the von Frey hair and acetone behavioral tests, we investigated the potential of GS centesimal (C) dilutions 3, 5, and 9C to prevent or to correct paclitaxel-induced cold allodynia and mechanical allodynia/hyperalgesia involved in neuropathic pain. We found that a prophylactic or corrective treatment with GS dilutions prevented or suppressed PAC-evoked cold allodynia and mechanical allodynia/hyperalgesia, by reversing to normal, decreased cold thermal and mechanical pain thresholds of PAC-treated rats. In particular, preventive or corrective treatments with GS dilution 3C counteracted PAC-evoked allodynic and hyperalgesic responses. Also, GS dilution 5C (in a lesser extent than 3C) significantly reduced PAC-induced mechanical allodynia/hyperalgesia while GS dilution 9C was ineffective. PAC-evoked neuropathic symptoms were efficiently reduced after 1 week treatment with GS dilutions 3 or 5C and the beneficial action increased after 2 weeks. GS dilutions, particularly 3C, also counteracted or prevented PAC-induced sciatic nerve axon alterations and decreased the density of intraepidermal nerve fibers. Altogether, these results obtained in the rat preclinical model suggest that GS dilution-based treatment may constitute an interesting option to explore for the long-term management of pain without undesirable effects.

Authors+Show Affiliations

Biopathologie de la Myéline, Neuroprotection et Stratégies Thérapeutiques, INSERM U1119, Fédération de Médecine Translationnelle de Strasbourg (FMTS), Université de Strasbourg, Bâtiment 3 de la Faculté de Médecine, 11 rue Humann, 67000, Strasbourg, France.Biopathologie de la Myéline, Neuroprotection et Stratégies Thérapeutiques, INSERM U1119, Fédération de Médecine Translationnelle de Strasbourg (FMTS), Université de Strasbourg, Bâtiment 3 de la Faculté de Médecine, 11 rue Humann, 67000, Strasbourg, France.Laboratoires BOIRON, Sainte-Foy-lès-Lyon, France.Biopathologie de la Myéline, Neuroprotection et Stratégies Thérapeutiques, INSERM U1119, Fédération de Médecine Translationnelle de Strasbourg (FMTS), Université de Strasbourg, Bâtiment 3 de la Faculté de Médecine, 11 rue Humann, 67000, Strasbourg, France. gmensah@unistra.fr.Biopathologie de la Myéline, Neuroprotection et Stratégies Thérapeutiques, INSERM U1119, Fédération de Médecine Translationnelle de Strasbourg (FMTS), Université de Strasbourg, Bâtiment 3 de la Faculté de Médecine, 11 rue Humann, 67000, Strasbourg, France. lmeyer@unistra.fr.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

30251080

Citation

Vitet, Ludivine, et al. "Beneficial Effects of Gelsemium-based Treatment Against Paclitaxel-induced Painful Symptoms." Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, vol. 39, no. 12, 2018, pp. 2183-2196.
Vitet L, Patte-Mensah C, Boujedaini N, et al. Beneficial effects of Gelsemium-based treatment against paclitaxel-induced painful symptoms. Neurol Sci. 2018;39(12):2183-2196.
Vitet, L., Patte-Mensah, C., Boujedaini, N., Mensah-Nyagan, A. G., & Meyer, L. (2018). Beneficial effects of Gelsemium-based treatment against paclitaxel-induced painful symptoms. Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 39(12), 2183-2196. https://doi.org/10.1007/s10072-018-3575-z
Vitet L, et al. Beneficial Effects of Gelsemium-based Treatment Against Paclitaxel-induced Painful Symptoms. Neurol Sci. 2018;39(12):2183-2196. PubMed PMID: 30251080.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Beneficial effects of Gelsemium-based treatment against paclitaxel-induced painful symptoms. AU - Vitet,Ludivine, AU - Patte-Mensah,Christine, AU - Boujedaini,Naoual, AU - Mensah-Nyagan,Ayikoé-Guy, AU - Meyer,Laurence, Y1 - 2018/09/24/ PY - 2018/05/11/received PY - 2018/09/14/accepted PY - 2018/9/27/pubmed PY - 2019/1/3/medline PY - 2018/9/26/entrez KW - Allodynia KW - Chemotherapy-induced painful neuropathy KW - Gelsemium KW - Hyperalgesia KW - Therapeutic strategy SP - 2183 EP - 2196 JF - Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology JO - Neurol Sci VL - 39 IS - 12 N2 - Chemotherapeutic drugs induce various side effects including painful peripheral neuropathy that represents a major concern. The widely used anticancer drug paclitaxel causes neurological side effects such as burning pain, allodynia, and hyperalgesia. Neuroprotective substances that may effectively counteract paclitaxel-induced neuropathic symptoms are needed. Here, we investigated the potential of Gelsemium sempervirens (GS) to counteract paclitaxel-evoked painful neuropathy in rats. Using the von Frey hair and acetone behavioral tests, we investigated the potential of GS centesimal (C) dilutions 3, 5, and 9C to prevent or to correct paclitaxel-induced cold allodynia and mechanical allodynia/hyperalgesia involved in neuropathic pain. We found that a prophylactic or corrective treatment with GS dilutions prevented or suppressed PAC-evoked cold allodynia and mechanical allodynia/hyperalgesia, by reversing to normal, decreased cold thermal and mechanical pain thresholds of PAC-treated rats. In particular, preventive or corrective treatments with GS dilution 3C counteracted PAC-evoked allodynic and hyperalgesic responses. Also, GS dilution 5C (in a lesser extent than 3C) significantly reduced PAC-induced mechanical allodynia/hyperalgesia while GS dilution 9C was ineffective. PAC-evoked neuropathic symptoms were efficiently reduced after 1 week treatment with GS dilutions 3 or 5C and the beneficial action increased after 2 weeks. GS dilutions, particularly 3C, also counteracted or prevented PAC-induced sciatic nerve axon alterations and decreased the density of intraepidermal nerve fibers. Altogether, these results obtained in the rat preclinical model suggest that GS dilution-based treatment may constitute an interesting option to explore for the long-term management of pain without undesirable effects. SN - 1590-3478 UR - https://www.unboundmedicine.com/medline/citation/30251080/Beneficial_effects_of_Gelsemium_based_treatment_against_paclitaxel_induced_painful_symptoms_ L2 - https://link.springer.com/10.1007/s10072-018-3575-z DB - PRIME DP - Unbound Medicine ER -