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Effects of supplementation with omega-3 fatty acids during pregnancy on asthma or wheeze of children: a systematic review and meta-analysis.
J Matern Fetal Neonatal Med. 2020 May; 33(10):1792-1801.JM

Abstract

Objective:

To evaluate the effects of omega-3 fatty acids during pregnancy on the incidence of wheeze and asthma of children.

Methods:

A search was conducted in PubMed, Embase and CENTRAL until September 2017. Randomized controlled trials (RCTs) assessing the effects of omega-3 fatty acids during pregnancy on wheeze/asthma of children were included. Two investigators independently searched articles, extracted data, and assessed the quality of included studies. Outcomes of relative risks were pooled. Subgroup analyses were conducted.

Results:

Seven RCTs involving 2047 children were included. The pooled data revealed the supplementation during pregnancy reduced the incidence of wheeze/asthma (risk ratio (RR) 0.81; 95% CI 0.66-0.99; p .04), but the incidence of childhood asthma was not significantly reduced (RR 0.89; 95% CI 0.67-1.17; p .40). Subgroup analyses indicated that the risk of childhood wheeze/asthma was significantly decreased (1) in studies located in Europe (RR 0.67 95% CI 0.51- 0.88), (2) in children whose first-degree relatives were diagnosed with allergic disease (RR 0.65 95% CI 0.49-0.85), (3) when a dose of omega -3 fatty acids ≥2000 mg/d was applied (RR 0.61 95% CI 0.45-0.81), (4) in wheeze/asthma without sensitivity (RR 0.71 95% CI 0.54-0.94).

Conclusion:

The available low-quality evidence indicated that omega-3 fatty acids supplementation during pregnancy may reduce the incidence of wheeze/asthma of children, but incidence of asthma was not reduced after omega-3 fatty acids supplementation during pregnancy. More well-designed RCTs with large sample sizes need to be conducted to better understand the effectiveness of omega-3 fatty acids supplementation during pregnancy with asthma in childhood.

Authors+Show Affiliations

Respiratory Department, Children's Hospital of Chongqing Medical University, Chongqing, China. Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing, China.Respiratory Department, Children's Hospital of Chongqing Medical University, Chongqing, China. Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing, China.Respiratory Department, Children's Hospital of Chongqing Medical University, Chongqing, China. Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing, China.Respiratory Department, Children's Hospital of Chongqing Medical University, Chongqing, China. Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing, China.Respiratory Department, Children's Hospital of Chongqing Medical University, Chongqing, China. Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing, China.

Pub Type(s)

Journal Article
Meta-Analysis
Systematic Review

Language

eng

PubMed ID

30253674

Citation

Lin, Jilei, et al. "Effects of Supplementation With Omega-3 Fatty Acids During Pregnancy On Asthma or Wheeze of Children: a Systematic Review and Meta-analysis." The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians, vol. 33, no. 10, 2020, pp. 1792-1801.
Lin J, Zhang Y, Zhu X, et al. Effects of supplementation with omega-3 fatty acids during pregnancy on asthma or wheeze of children: a systematic review and meta-analysis. J Matern Fetal Neonatal Med. 2020;33(10):1792-1801.
Lin, J., Zhang, Y., Zhu, X., Wang, D., & Dai, J. (2020). Effects of supplementation with omega-3 fatty acids during pregnancy on asthma or wheeze of children: a systematic review and meta-analysis. The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians, 33(10), 1792-1801. https://doi.org/10.1080/14767058.2018.1529161
Lin J, et al. Effects of Supplementation With Omega-3 Fatty Acids During Pregnancy On Asthma or Wheeze of Children: a Systematic Review and Meta-analysis. J Matern Fetal Neonatal Med. 2020;33(10):1792-1801. PubMed PMID: 30253674.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of supplementation with omega-3 fatty acids during pregnancy on asthma or wheeze of children: a systematic review and meta-analysis. AU - Lin,Jilei, AU - Zhang,Yin, AU - Zhu,Xiaohong, AU - Wang,Donghai, AU - Dai,Jihong, Y1 - 2018/10/29/ PY - 2018/9/27/pubmed PY - 2021/1/27/medline PY - 2018/9/27/entrez KW - Asthma KW - children KW - meta-analysis KW - omega-3 fatty acids KW - pregnancy KW - wheeze SP - 1792 EP - 1801 JF - The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians JO - J Matern Fetal Neonatal Med VL - 33 IS - 10 N2 - Objective: To evaluate the effects of omega-3 fatty acids during pregnancy on the incidence of wheeze and asthma of children.Methods: A search was conducted in PubMed, Embase and CENTRAL until September 2017. Randomized controlled trials (RCTs) assessing the effects of omega-3 fatty acids during pregnancy on wheeze/asthma of children were included. Two investigators independently searched articles, extracted data, and assessed the quality of included studies. Outcomes of relative risks were pooled. Subgroup analyses were conducted.Results: Seven RCTs involving 2047 children were included. The pooled data revealed the supplementation during pregnancy reduced the incidence of wheeze/asthma (risk ratio (RR) 0.81; 95% CI 0.66-0.99; p .04), but the incidence of childhood asthma was not significantly reduced (RR 0.89; 95% CI 0.67-1.17; p .40). Subgroup analyses indicated that the risk of childhood wheeze/asthma was significantly decreased (1) in studies located in Europe (RR 0.67 95% CI 0.51- 0.88), (2) in children whose first-degree relatives were diagnosed with allergic disease (RR 0.65 95% CI 0.49-0.85), (3) when a dose of omega -3 fatty acids ≥2000 mg/d was applied (RR 0.61 95% CI 0.45-0.81), (4) in wheeze/asthma without sensitivity (RR 0.71 95% CI 0.54-0.94).Conclusion: The available low-quality evidence indicated that omega-3 fatty acids supplementation during pregnancy may reduce the incidence of wheeze/asthma of children, but incidence of asthma was not reduced after omega-3 fatty acids supplementation during pregnancy. More well-designed RCTs with large sample sizes need to be conducted to better understand the effectiveness of omega-3 fatty acids supplementation during pregnancy with asthma in childhood. SN - 1476-4954 UR - https://www.unboundmedicine.com/medline/citation/30253674/Effects_of_supplementation_with_omega_3_fatty_acids_during_pregnancy_on_asthma_or_wheeze_of_children:_a_systematic_review_and_meta_analysis_ L2 - https://www.tandfonline.com/doi/full/10.1080/14767058.2018.1529161 DB - PRIME DP - Unbound Medicine ER -