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The Association Between Overactive Bladder and Falls and Fractures: A Systematic Review.
Adv Ther. 2018 11; 35(11):1831-1841.AT

Abstract

INTRODUCTION

Urinary symptoms are associated with an increased risk of falls, but few studies have focused on patients with overactive bladder (OAB). This study aimed to synthesize estimates of the risk of falls and fractures in patients with OAB.

METHODS

Medline, EMBASE, the Cumulative Index to Nursing and Allied Health Literature, and Scopus were systematically searched for observational studies that focused on patients with OAB. When available, data from a non-OAB comparison sample were included. Double independent review and data extraction were performed. Falls and fractures data were summarized by unadjusted and adjusted risks, and percent attributable risk (PAR) of falls and fractures associated with OAB.

RESULTS

Fifteen studies were included in the analyses. The proportion of patients with OAB experiencing at least one fall over a year ranged from 18.9% to 50.0%, and the proportion of patients with OAB experiencing recurrent or serious falls ranged from 10.2% to 56.0%. In studies that included a non-OAB comparison sample, a higher risk of falls was observed in patients with OAB compared to those without. A significantly increased (1.3- to 2.3-fold) adjusted OAB-associated risk of falls was reported, while unadjusted PARs for OAB associated falls ranged from 3.7% to 15.5%. Risk was higher among women and those 65 years of age or older. While analysis of fractures showed elevated point estimates, most studies were underpowered to detect a statistically significant difference between groups.

CONCLUSIONS

Evidence from the published literature clearly demonstrates the importance of OAB and its symptoms as risk factors for falls and fractures.

FUNDING

Astellas.

Authors+Show Affiliations

Broadstreet Health Economics and Outcomes Research, Vancouver, Canada. sszabo@broadstreetheor.com.Astellas Pharma Global Development, Inc., Northbrook, IL, USA.Astellas Pharma Global Development, Inc., Northbrook, IL, USA.Broadstreet Health Economics and Outcomes Research, Vancouver, Canada.University of Alberta, Edmonton, Canada.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Systematic Review

Language

eng

PubMed ID

30255417

Citation

Szabo, Shelagh M., et al. "The Association Between Overactive Bladder and Falls and Fractures: a Systematic Review." Advances in Therapy, vol. 35, no. 11, 2018, pp. 1831-1841.
Szabo SM, Gooch KL, Walker DR, et al. The Association Between Overactive Bladder and Falls and Fractures: A Systematic Review. Adv Ther. 2018;35(11):1831-1841.
Szabo, S. M., Gooch, K. L., Walker, D. R., Johnston, K. M., & Wagg, A. S. (2018). The Association Between Overactive Bladder and Falls and Fractures: A Systematic Review. Advances in Therapy, 35(11), 1831-1841. https://doi.org/10.1007/s12325-018-0796-8
Szabo SM, et al. The Association Between Overactive Bladder and Falls and Fractures: a Systematic Review. Adv Ther. 2018;35(11):1831-1841. PubMed PMID: 30255417.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The Association Between Overactive Bladder and Falls and Fractures: A Systematic Review. AU - Szabo,Shelagh M, AU - Gooch,Katherine L, AU - Walker,David R, AU - Johnston,Karissa M, AU - Wagg,Adrian S, Y1 - 2018/09/25/ PY - 2018/07/17/received PY - 2018/9/27/pubmed PY - 2019/9/26/medline PY - 2018/9/27/entrez KW - Accidental falls KW - Fractures, bone KW - Overactive KW - Review KW - Urinary bladder KW - Urology SP - 1831 EP - 1841 JF - Advances in therapy JO - Adv Ther VL - 35 IS - 11 N2 - INTRODUCTION: Urinary symptoms are associated with an increased risk of falls, but few studies have focused on patients with overactive bladder (OAB). This study aimed to synthesize estimates of the risk of falls and fractures in patients with OAB. METHODS: Medline, EMBASE, the Cumulative Index to Nursing and Allied Health Literature, and Scopus were systematically searched for observational studies that focused on patients with OAB. When available, data from a non-OAB comparison sample were included. Double independent review and data extraction were performed. Falls and fractures data were summarized by unadjusted and adjusted risks, and percent attributable risk (PAR) of falls and fractures associated with OAB. RESULTS: Fifteen studies were included in the analyses. The proportion of patients with OAB experiencing at least one fall over a year ranged from 18.9% to 50.0%, and the proportion of patients with OAB experiencing recurrent or serious falls ranged from 10.2% to 56.0%. In studies that included a non-OAB comparison sample, a higher risk of falls was observed in patients with OAB compared to those without. A significantly increased (1.3- to 2.3-fold) adjusted OAB-associated risk of falls was reported, while unadjusted PARs for OAB associated falls ranged from 3.7% to 15.5%. Risk was higher among women and those 65 years of age or older. While analysis of fractures showed elevated point estimates, most studies were underpowered to detect a statistically significant difference between groups. CONCLUSIONS: Evidence from the published literature clearly demonstrates the importance of OAB and its symptoms as risk factors for falls and fractures. FUNDING: Astellas. SN - 1865-8652 UR - https://www.unboundmedicine.com/medline/citation/30255417/The_Association_Between_Overactive_Bladder_and_Falls_and_Fractures:_A_Systematic_Review_ L2 - https://dx.doi.org/10.1007/s12325-018-0796-8 DB - PRIME DP - Unbound Medicine ER -