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Meta-analysis of the effects of probiotic supplementation on glycemia, lipidic profiles, weight loss and C-reactive protein in women with polycystic ovarian syndrome.
Minerva Med. 2018 Dec; 109(6):479-487.MM

Abstract

INTRODUCTION

Several studies have been designed to investigate the beneficial effects of probiotic supplementation on metabolic parameters and inflammation status in women with polycystic ovarian syndrome (PCOS), but results have been inconsistent. Herein, we perform a meta-analysis of randomized controlled trials (RCTs) to evaluate the effects of probiotic supplementation on glycemia control, lipidic profiles, weight loss and C-reactive protein (CRP) in women with PCOS.

EVIDENCE ACQUISITION

MELINE, EMBASE, and Cochrane Library were searched for RCTs that investigated the effects of probiotic in women with PCOS. Two investigators independently performed the screening, data extraction, and methodological quality assessment. Data were pooled as mean differences (MDs) with 95% confidence intervals (CIs). The statistical heterogeneity was assessed with the I2 test. Sensitivity analyses were performed by the leave-one-out approach.

EVIDENCE SYNTHESIS

From the literature search, 26 publications were screened and 6 RCTs involving 406 PCOS participants (aged 25-28.5 years) with follow-up period between 8-12 weeks were included. The pooled results showed that probiotic supplement significantly affected the levels of fasting blood insulin (FBI), quantitative insulin sensitivity check index (QUICKI), triglycerides (TG), and very low density lipoprotein-cholesterol (VLDL-C). However, no significant changes were found in other markers, including fasting plasma glucose, homeostatic model assessment-insulin resistance, total cholesterol, low-density lipoprotein-cholesterol, high-density lipoprotein-cholesterol, body weight, CRP, and dehydroepiandrosterone sulfate levels. The pooled result was robust after the sensitivity analysis.

CONCLUSIONS

Our finding provides evidence that daily probiotic consumption has beneficial effects on decreasing FBI, TG, and VLDL-C, and increasing the QUICKI score in PCOS patients.

Authors+Show Affiliations

Department of Gynecology and Obstetrics, Dongguan Third People's Hospital, Affiliated Dongguan Shilong People's Hospital of Southern Medical University, Dongguan, Guangdong, China.Department of Gynecology and Obstetrics, Dongguan Third People's Hospital, Affiliated Dongguan Shilong People's Hospital of Southern Medical University, Dongguan, Guangdong, China.Department of Gynecology and Obstetrics, Dongguan Third People's Hospital, Affiliated Dongguan Shilong People's Hospital of Southern Medical University, Dongguan, Guangdong, China.Department of Gynecology and Obstetrics, Dongguan Third People's Hospital, Affiliated Dongguan Shilong People's Hospital of Southern Medical University, Dongguan, Guangdong, China.Department of Gynecology and Obstetrics, Dongguan Third People's Hospital, Affiliated Dongguan Shilong People's Hospital of Southern Medical University, Dongguan, Guangdong, China - yyanliu_md@163.com.

Pub Type(s)

Journal Article
Meta-Analysis

Language

eng

PubMed ID

30256077

Citation

Liao, Dan, et al. "Meta-analysis of the Effects of Probiotic Supplementation On Glycemia, Lipidic Profiles, Weight Loss and C-reactive Protein in Women With Polycystic Ovarian Syndrome." Minerva Medica, vol. 109, no. 6, 2018, pp. 479-487.
Liao D, Zhong C, Li C, et al. Meta-analysis of the effects of probiotic supplementation on glycemia, lipidic profiles, weight loss and C-reactive protein in women with polycystic ovarian syndrome. Minerva Med. 2018;109(6):479-487.
Liao, D., Zhong, C., Li, C., Mo, L., & Liu, Y. (2018). Meta-analysis of the effects of probiotic supplementation on glycemia, lipidic profiles, weight loss and C-reactive protein in women with polycystic ovarian syndrome. Minerva Medica, 109(6), 479-487. https://doi.org/10.23736/S0026-4806.18.05728-2
Liao D, et al. Meta-analysis of the Effects of Probiotic Supplementation On Glycemia, Lipidic Profiles, Weight Loss and C-reactive Protein in Women With Polycystic Ovarian Syndrome. Minerva Med. 2018;109(6):479-487. PubMed PMID: 30256077.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Meta-analysis of the effects of probiotic supplementation on glycemia, lipidic profiles, weight loss and C-reactive protein in women with polycystic ovarian syndrome. AU - Liao,Dan, AU - Zhong,Chunhua, AU - Li,Cuifen, AU - Mo,Lifang, AU - Liu,Yanyan, Y1 - 2018/09/24/ PY - 2018/9/27/pubmed PY - 2018/12/20/medline PY - 2018/9/27/entrez SP - 479 EP - 487 JF - Minerva medica JO - Minerva Med VL - 109 IS - 6 N2 - INTRODUCTION: Several studies have been designed to investigate the beneficial effects of probiotic supplementation on metabolic parameters and inflammation status in women with polycystic ovarian syndrome (PCOS), but results have been inconsistent. Herein, we perform a meta-analysis of randomized controlled trials (RCTs) to evaluate the effects of probiotic supplementation on glycemia control, lipidic profiles, weight loss and C-reactive protein (CRP) in women with PCOS. EVIDENCE ACQUISITION: MELINE, EMBASE, and Cochrane Library were searched for RCTs that investigated the effects of probiotic in women with PCOS. Two investigators independently performed the screening, data extraction, and methodological quality assessment. Data were pooled as mean differences (MDs) with 95% confidence intervals (CIs). The statistical heterogeneity was assessed with the I2 test. Sensitivity analyses were performed by the leave-one-out approach. EVIDENCE SYNTHESIS: From the literature search, 26 publications were screened and 6 RCTs involving 406 PCOS participants (aged 25-28.5 years) with follow-up period between 8-12 weeks were included. The pooled results showed that probiotic supplement significantly affected the levels of fasting blood insulin (FBI), quantitative insulin sensitivity check index (QUICKI), triglycerides (TG), and very low density lipoprotein-cholesterol (VLDL-C). However, no significant changes were found in other markers, including fasting plasma glucose, homeostatic model assessment-insulin resistance, total cholesterol, low-density lipoprotein-cholesterol, high-density lipoprotein-cholesterol, body weight, CRP, and dehydroepiandrosterone sulfate levels. The pooled result was robust after the sensitivity analysis. CONCLUSIONS: Our finding provides evidence that daily probiotic consumption has beneficial effects on decreasing FBI, TG, and VLDL-C, and increasing the QUICKI score in PCOS patients. SN - 1827-1669 UR - https://www.unboundmedicine.com/medline/citation/30256077/Meta_analysis_of_the_effects_of_probiotic_supplementation_on_glycemia_lipidic_profiles_weight_loss_and_C_reactive_protein_in_women_with_polycystic_ovarian_syndrome_ DB - PRIME DP - Unbound Medicine ER -