Tags

Type your tag names separated by a space and hit enter

Prenatal Household Air Pollution Is Associated with Impaired Infant Lung Function with Sex-Specific Effects. Evidence from GRAPHS, a Cluster Randomized Cookstove Intervention Trial.
Am J Respir Crit Care Med 2019; 199(6):738-746AJ

Abstract

RATIONALE

Approximately 2.8 billion people are exposed daily to household air pollution from polluting cookstoves. The effects of prenatal household air pollution on lung development are unknown.

OBJECTIVES

To prospectively examine associations between prenatal household air pollution and infant lung function and pneumonia in rural Ghana.

METHODS

Prenatal household air pollution exposure was indexed by serial maternal carbon monoxide personal exposure measurements. Using linear regression, we examined associations between average prenatal carbon monoxide and infant lung function at age 30 days, first in the entire cohort (n = 384) and then stratified by sex. Quasi-Poisson generalized additive models explored associations between infant lung function and pneumonia.

MEASUREMENTS AND MAIN RESULTS

Multivariable linear regression models showed that average prenatal carbon monoxide exposure was associated with reduced time to peak tidal expiratory flow to expiratory time (β = -0.004; P = 0.01), increased respiratory rate (β = 0.28; P = 0.01), and increased minute ventilation (β = 7.21; P = 0.05), considered separately, per 1 ppm increase in average prenatal carbon monoxide. Sex-stratified analyses suggested that girls were particularly vulnerable (time to peak tidal expiratory flow to expiratory time: β = -0.003, P = 0.05; respiratory rate: β = 0.36, P = 0.01; minute ventilation: β = 11.25, P = 0.01; passive respiratory compliance normalized for body weight: β = 0.005, P = 0.01). Increased respiratory rate at age 30 days was associated with increased risk for physician-assessed pneumonia (relative risk, 1.02; 95% confidence interval, 1.00-1.04) and severe pneumonia (relative risk, 1.04; 95% confidence interval, 1.00-1.08) in the first year of life.

CONCLUSIONS

Increased prenatal household air pollution exposure is associated with impaired infant lung function. Altered infant lung function may increase risk for pneumonia in the first year of life. These findings have implications for future respiratory health. Clinical trial registered with www.clinicaltrials.gov (NCT 01335490).

Authors+Show Affiliations

1 Division of Pulmonary, Critical Care and Sleep Medicine, Icahn School of Medicine at Mount Sinai, New York, New York.2 Kintampo Health Research Centre, Ghana Health Service, Brong Ahafo Region, Kintampo, Ghana.3 Fogarty International Center, National Institutes of Health, Bethesda, Maryland.4 Department of Biomedical Sciences, University of Health and Allied Services, Volta Region, Ghana.5 Department of Environmental Health Sciences, Columbia University Mailman School of Public Health, New York, New York.2 Kintampo Health Research Centre, Ghana Health Service, Brong Ahafo Region, Kintampo, Ghana.6 Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, Beth Israel Deaconess Medical Center, Boston, Massacusetts.2 Kintampo Health Research Centre, Ghana Health Service, Brong Ahafo Region, Kintampo, Ghana.7 Department of Health, Boston University School of Public Health, Boston, Massachusetts; and.2 Kintampo Health Research Centre, Ghana Health Service, Brong Ahafo Region, Kintampo, Ghana.8 Lamont-Doherty Earth Observatory at Columbia University, Palisades, New York.5 Department of Environmental Health Sciences, Columbia University Mailman School of Public Health, New York, New York.2 Kintampo Health Research Centre, Ghana Health Service, Brong Ahafo Region, Kintampo, Ghana.

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

30256656

Citation

Lee, Alison G., et al. "Prenatal Household Air Pollution Is Associated With Impaired Infant Lung Function With Sex-Specific Effects. Evidence From GRAPHS, a Cluster Randomized Cookstove Intervention Trial." American Journal of Respiratory and Critical Care Medicine, vol. 199, no. 6, 2019, pp. 738-746.
Lee AG, Kaali S, Quinn A, et al. Prenatal Household Air Pollution Is Associated with Impaired Infant Lung Function with Sex-Specific Effects. Evidence from GRAPHS, a Cluster Randomized Cookstove Intervention Trial. Am J Respir Crit Care Med. 2019;199(6):738-746.
Lee, A. G., Kaali, S., Quinn, A., Delimini, R., Burkart, K., Opoku-Mensah, J., ... Asante, K. P. (2019). Prenatal Household Air Pollution Is Associated with Impaired Infant Lung Function with Sex-Specific Effects. Evidence from GRAPHS, a Cluster Randomized Cookstove Intervention Trial. American Journal of Respiratory and Critical Care Medicine, 199(6), pp. 738-746. doi:10.1164/rccm.201804-0694OC.
Lee AG, et al. Prenatal Household Air Pollution Is Associated With Impaired Infant Lung Function With Sex-Specific Effects. Evidence From GRAPHS, a Cluster Randomized Cookstove Intervention Trial. Am J Respir Crit Care Med. 2019 03 15;199(6):738-746. PubMed PMID: 30256656.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Prenatal Household Air Pollution Is Associated with Impaired Infant Lung Function with Sex-Specific Effects. Evidence from GRAPHS, a Cluster Randomized Cookstove Intervention Trial. AU - Lee,Alison G, AU - Kaali,Seyram, AU - Quinn,Ashlinn, AU - Delimini,Rupert, AU - Burkart,Katrin, AU - Opoku-Mensah,Jones, AU - Wylie,Blair J, AU - Yawson,Abena Konadu, AU - Kinney,Patrick L, AU - Ae-Ngibise,Kenneth A, AU - Chillrud,Steven, AU - Jack,Darby, AU - Asante,Kwaku Poku, PY - 2020/03/15/pmc-release PY - 2018/9/27/pubmed PY - 2020/1/9/medline PY - 2018/9/27/entrez KW - household air pollution KW - lung development KW - lung function KW - pneumonia KW - sex-specific effects SP - 738 EP - 746 JF - American journal of respiratory and critical care medicine JO - Am. J. Respir. Crit. Care Med. VL - 199 IS - 6 N2 - RATIONALE: Approximately 2.8 billion people are exposed daily to household air pollution from polluting cookstoves. The effects of prenatal household air pollution on lung development are unknown. OBJECTIVES: To prospectively examine associations between prenatal household air pollution and infant lung function and pneumonia in rural Ghana. METHODS: Prenatal household air pollution exposure was indexed by serial maternal carbon monoxide personal exposure measurements. Using linear regression, we examined associations between average prenatal carbon monoxide and infant lung function at age 30 days, first in the entire cohort (n = 384) and then stratified by sex. Quasi-Poisson generalized additive models explored associations between infant lung function and pneumonia. MEASUREMENTS AND MAIN RESULTS: Multivariable linear regression models showed that average prenatal carbon monoxide exposure was associated with reduced time to peak tidal expiratory flow to expiratory time (β = -0.004; P = 0.01), increased respiratory rate (β = 0.28; P = 0.01), and increased minute ventilation (β = 7.21; P = 0.05), considered separately, per 1 ppm increase in average prenatal carbon monoxide. Sex-stratified analyses suggested that girls were particularly vulnerable (time to peak tidal expiratory flow to expiratory time: β = -0.003, P = 0.05; respiratory rate: β = 0.36, P = 0.01; minute ventilation: β = 11.25, P = 0.01; passive respiratory compliance normalized for body weight: β = 0.005, P = 0.01). Increased respiratory rate at age 30 days was associated with increased risk for physician-assessed pneumonia (relative risk, 1.02; 95% confidence interval, 1.00-1.04) and severe pneumonia (relative risk, 1.04; 95% confidence interval, 1.00-1.08) in the first year of life. CONCLUSIONS: Increased prenatal household air pollution exposure is associated with impaired infant lung function. Altered infant lung function may increase risk for pneumonia in the first year of life. These findings have implications for future respiratory health. Clinical trial registered with www.clinicaltrials.gov (NCT 01335490). SN - 1535-4970 UR - https://www.unboundmedicine.com/medline/citation/30256656/Prenatal_Household_Air_Pollution_Is_Associated_with_Impaired_Infant_Lung_Function_with_Sex_Specific_Effects__Evidence_from_GRAPHS_a_Cluster_Randomized_Cookstove_Intervention_Trial_ L2 - http://www.atsjournals.org/doi/full/10.1164/rccm.201804-0694OC?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -